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Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 Proteins (SLC7A8)

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Additionally we are shipping SLC7A8 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC7A8 23428 Q9UHI5
Rat SLC7A8 SLC7A8 84551 Q9WVR6
SLC7A8 50934 Q9QXW9
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Top SLC7A8 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

SLC7A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) Interaction Partners

Pig (Porcine) Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. molecular cloning of LAT2 (show LAT2 Proteins)

Human Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. LAT1 (show LAT Proteins) and LAT2 (show LAT2 Proteins) are present and functional in the syncytiotrophoblast MVM, whereas LAT2 (show LAT2 Proteins) is also expressed in the BM and in the fetal capillary endothelium.

  2. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.

  3. the interaction of CD98 (show SLC3A2 Proteins)/LAT2 (show LAT2 Proteins) with ICAM-1 (show ICAM1 Proteins), found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE (show ENO3 Proteins) cell monolayers

  4. identify LAT1 (show LAT Proteins) and LAT2 (show LAT2 Proteins) as members of system L that mediate transmembrane movement of l-CSNO

  5. Genetic variation in LAT1 (show LAT Proteins) and LAT2 (show LAT2 Proteins) does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.

Mouse (Murine) Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive (show THRSP Proteins) genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone (show PTH Proteins) transporter Mct8 (show MCT8 Proteins), which is co-expressed in many cell types

  2. the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc (show SLC3A2 Proteins), by recycling its aromatic influx substrates

  3. The positive effect of non-T cell activation linker (NTAL (show LAT2 Proteins)) on Akt (show AKT1 Proteins) phosphorylation and mast cell survival requires LAT (show LAT Proteins).

  4. LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP (show SLC10A1 Proteins) mRNAs were not.

SLC7A8 Protein Profile

Protein Summary

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).

Gene names and symbols associated with SLC7A8

  • solute carrier family 7 (amino acid transporter light chain, L system), member 8 (slc7a8)
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8 (SLC7A8)
  • solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8)
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8 (Slc7a8)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (slc7a8)
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8)
  • 4F2LC-5 protein
  • AA408822 protein
  • Lat2 protein
  • Lat4 protein
  • LPI-PC1 protein
  • si:ch211-14a17.3 protein
  • si:zc14a17.3 protein
  • XAA2 protein

Protein level used designations for SLC7A8

solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 , solute carrier family 7 (amino acid transporter, L-type), member 8 , large neutral amino acids transporter small subunit 2 , L-type amino acid transporter 2 , solute carrier family 7 member 8 , integral membrane protein E16H , glycoprotein-associated amino acid transporter LAT2 , 4F2-LC5 , cationic amino acid transporter y+ system , mLAT2 , solute carrier family 8 (cationic amino acid transporter, y+ system), member 7

GENE ID SPECIES
394580 Xenopus (Silurana) tropicalis
452793 Pan troglodytes
713511 Macaca mulatta
100134829 Sus scrofa
100172820 Pongo abelii
380297 Xenopus laevis
23428 Homo sapiens
490608 Canis lupus familiaris
536818 Bos taurus
100009408 Oryctolagus cuniculus
84551 Rattus norvegicus
368665 Danio rerio
50934 Mus musculus
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