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Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Additionally we are shipping SLC7A8 Antibodies (39) and many more products for this protein.
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LAT1 (show LAT Proteins) and LAT2 (show LAT2 Proteins) are present and functional in the syncytiotrophoblast MVM, whereas LAT2 (show LAT2 Proteins) is also expressed in the BM and in the fetal capillary endothelium.
Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.
the interaction of CD98 (show SLC3A2 Proteins)/LAT2 (show LAT2 Proteins) with ICAM-1 (show ICAM1 Proteins), found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE (show ENO3 Proteins) cell monolayers
identify LAT1 (show LAT Proteins) and LAT2 (show LAT2 Proteins) as members of system L that mediate transmembrane movement of l-CSNO
Genetic variation in LAT1 (show LAT Proteins) and LAT2 (show LAT2 Proteins) does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.
distinct molecular LAT2-features determine bidirectional amino acid transport but only an unidirectional thyroid hormone (show PTH Proteins) import.
Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive (show THRSP Proteins) genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone (show PTH Proteins) transporter Mct8 (show MCT8 Proteins), which is co-expressed in many cell types
the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc (show SLC3A2 Proteins), by recycling its aromatic influx substrates
The positive effect of non-T cell activation linker (NTAL (show LAT2 Proteins)) on Akt (show AKT1 Proteins) phosphorylation and mast cell survival requires LAT (show LAT Proteins).
LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP (show SLC10A1 Proteins) mRNAs were not.
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).
L-type amino acid transporter 2
, integral membrane protein E16H
, large neutral amino acids transporter small subunit 2
, solute carrier family 7 (amino acid transporter, L-type), member 8
, solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
, cationic amino acid transporter y+ system
, solute carrier family 7 member 8
, glycoprotein-associated amino acid transporter LAT2
, solute carrier family 8 (cationic amino acid transporter, y+ system), member 7
, solute carrier family 7 (amino acid transporter light chain, L system), member 8