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Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Additionally we are shipping SORBS1 Antibodies (81) and SORBS1 Kits (4) and many more products for this protein.
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association between common SORBS1 genetic variations and blood pressure, presence of hypertension, and age at onset of hypertension
data suggest that SORBS1 might be a gene involved in diabetic nephropathy.
Our NMR and ITC data indicate that the SH3a and SH3b domains of CAP simultaneously bind to a long proline-rich region of vinculin (show VCL Proteins) with different binding specificities
Sequestration of the ponsin splice variant R85FL by the polyglutamine-expanded Atx7 in cell is mediated by the specific SH3C-PRR (show PVRL1 Proteins) interaction, which is implicated in the pathogenesis of spinocerebellar ataxia (show USP14 Proteins) 7.
a novel signaling network containing FRS2 (show FRS2 Proteins), CAP and flotillin-1 (show FLOT1 Proteins)
The novel ponsin isoform and its interaction with Nck1 (show NCK1 Proteins)/2 provide exciting insight into the convergence of signalling pathways at the costameres, and its crucial role for skeletal muscle differentiation and re-generation.
preliminary results indicate the depot-specific differential expression of sorbin and SH3 domain-containing-1(SORBS1) in relation to body mass index
SORBS1 polymorphism does not play a major role in premature pubarche, hyperandrogenism, and/or polycystic ovary syndrome in children and adolescent girls.
Soluble intracellular domain of teneurin-1 (show ODZ1 Proteins) binds to the cell membrane enriched in CAP/ponsin
analysis of paxillin (show PXN Proteins) and ponsin interaction in nascent costameres of muscle cells
The study screened CrkL (show CRKL Proteins) binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 (show Sorbs2 Proteins) as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Suggest a novel modulatory role for CAP in the heart as a key protein stabilizing antiviral type I interferon (show IFNA Proteins) production, while protecting from excessive cytotoxic responses in CVB3 mediated endocarditis.
Low- and high-dose ursolic acid can improve the glycometabolism and differentiation of 3T3-L1 adipocytes with insulin (show INS Proteins) resistance by up-regulating the expression of CAP.
CAP, Cbl (show CBL Proteins) iso-forms, and CrkII (show CRK Proteins) are not required components of insulin (show INS Proteins) signaling to GLUT4 (show SLC2A4 Proteins) transporters
Bone marrow-specific Sorbs1 (Cap) gene deletion protects against high-fat diet-induced insulin (show INS Proteins) resistance.
These data provide a mechanism for the lipid raft localization of TrkA (show NTRK1 Proteins) and establish the importance of the CAP adaptor protein for nerve growth factor activation of the extracellular signal-regulated kinase and neuronal differentiation.
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Fas-ligand associated factor 2
, SH3 domain protein 5
, SH3-domain protein 5 (ponsin)
, c-Cbl associated protein
, c-Cbl-associated protein
, sorbin and SH3 domain-containing protein 1