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SORCS1 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. Additionally we are shipping SORCS1 Antibodies (37) and SORCS1 Kits (9) and many more products for this protein.
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Here the authors have characterized SorCS1, SorCS2 (show SORCS2 Proteins) and SorCS3 (show SORCS3 Proteins) using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations.
We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin (show INS Proteins) secretion in obese women with polycystic ovary syndrome. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels and increased glucose stimulated insulin (show INS Proteins) secretion
Data identified associations between single nucleotide polymorphisms in SORCS1 and renal function in large cohorts of European and African ancestry.
The propeptide region of sorCS1 contains two separate sites for binding to sortilin (show SORT1 Proteins). One of these sites is removed from human sorCS1 during processing.
Genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 is associated with late onset Alzheimer disease in the Chinese Han population.
The genetic link between AD[Alzheimer's disease]and SORCS1 gene variations are influenced by ethnic background, sex and whether an individual has type 2 diabetes mellitus
Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population
suggest that genetic variation in SORCS1 is associated with memory performance
the 4 recently reported SNPs,located near BNC2, SORCS1, GSC (show GSC Proteins) and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 SNP, findings do not rule out possible relationship with HbA1c
Dysfunction of SorCS1 may contribute to both the amyloid precursor protein (show APP Proteins)/amyloidbeta disturbance underlying Alzheimer disease and the insulin (show INS Proteins)/glucose disturbance underlying diabetes mellitus.
Male mice with either the APP (show APP Proteins)/PSEN1 (show PSEN1 Proteins) or Sorcs1 -/- genotype displayed earlier onset and persistent impairment in both glucose homeostasis and in learning behavior.
SorCS1 and APP (show APP Proteins) share trafficking pathways and that SorCS1c can retain APP (show APP Proteins) from insertion into anterograde transport vesicles
SorCs1 is a global protein trafficking regulator, including AMPA (show GRIA3 Proteins) receptors and neurexins.
SORCS1 is sufficient to promote secretory granule biogenesis in metabolically stressed beta cells
SorCS3 (show SORCS3 Proteins) and the homologous sorCS1 and sorCS2 (show SORCS2 Proteins) genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 (show SORCS3 Proteins) did not require protein synthesis
identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus
Different motifs regulate trafficking of Sorcs isoforms.
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain\; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins\; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified.
VPS10 domain receptor protein SORCS 1
, VPS10 domain-containing receptor SorCS1