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anti-Spectrin Beta, Non-Erythrocytic 1 (SPTBN1) Antibodies

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles.

list all antibodies Gene Name GeneID UniProt
SPTBN1 20742 Q62261
SPTBN1 6711 Q01082
SPTBN1 305614  
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Top anti-SPTBN1 Antibodies at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of beta-Spectrin II on Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of beta-Spectrin II. Immunofluorescent staining of Hela cells grown on microscope slides with beta-Spectrin II monoclonal antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using SPTBN1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, WB   200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IP, WB   20 μg Log in to see 8 to 10 Days
$815.83
Details

SPTBN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)
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Human , ,
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Rat (Rattus)
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Top referenced anti-SPTBN1 Antibodies

  1. Dog (Canine) Monoclonal SPTBN1 Primary Antibody for IF, WB - ABIN968882 : Hu, Watanabe, Bennett: Characterization of human brain cDNA encoding the general isoform of beta-spectrin. in The Journal of biological chemistry 1992 (PubMed)
    Show all 3 references for ABIN968882

More Antibodies against SPTBN1 Interaction Partners

Mouse (Murine) Spectrin Beta, Non-Erythrocytic 1 (SPTBN1) interaction partners

  1. The findings showed that beta-2 spectrin plays a crucial role in hepatocyte proliferation, which contributes to liver regeneration. PI3K/Akt was involved in TGFbeta/Smad signalling pathway through the interaction with Smad proteins and beta-2 spectrin.

  2. These data reveal that embryonic liver fodrin is involved in hepatic stellate cell activation and the formation of regenerative nodules derived from hepatic progenitor cells in cirrhotic liver.

  3. Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.

  4. costamere-association of dynactin-4 did not require dystrophin but did depend on beta2 spectrin and ankyrin-B, whereas costamere association of ankyrin-B required beta2 spectrin

  5. ELF is involved in the pathogenesis of primary biliary cirrhosis and hepatocellular carcinoma.

  6. Data show that Spnb2 [beta2SP(+/-)] mice are born with many phenotypic characteristics observed in BW (show CDKN1C Antibodies)S patients, suggesting that beta2SP mutant mice phenocopy BWS, and beta2SP loss could be one of the mechanisms associated with BWS.

  7. downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin

  8. results point to ELF as an essential adaptor protein required for key events in the propagation of TGF-beta (show TGFB1 Antibodies) signaling

  9. interaction between members of the ankyrin and beta-spectrin families previously established in erythrocytes and axon initial segments also occurs in neonatal cardiomyocytes with ankyrin-B and beta(2)-spectrin.

  10. In response to ELF deficiency, the abnormalities of G1/S checkpoint and senescence contribute their increment of susceptibility to malignant transformation.

Human Spectrin Beta, Non-Erythrocytic 1 (SPTBN1) interaction partners

  1. TGF-beta1 (show TGFB1 Antibodies) and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC (show FAM126A Antibodies) patients after hepatic resection.

  2. betaII spectrin is critical for normal myocyte electric activity. Dysfunction in the betaII spectrin-dependent cytoskeleton in cardiomyocytes contributes to human arrhythmia.

  3. decreased SPTBN1 and kallistatin (show SERPINA4 Antibodies) gene expression associated with decreased relapse-free survival in hepatocellular carcinoma

  4. in human HCC (show FAM126A Antibodies) tissues, SPTBN1 expression correlated negatively with expression levels of STAT3 (show STAT3 Antibodies), ATF3 (show ATF3 Antibodies), and CREB2 (show ATF4 Antibodies); SMAD3 (show SMAD3 Antibodies) expression correlated negatively with STAT3 (show STAT3 Antibodies) expression

  5. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in SPTBN1 (rs11898505) is associated with osteoporotic fractures and bone mineral density of lumbar spine in aging women.

  6. These results suggest that alpha-synuclein (show SNCA Antibodies) modulates neurite outgrowth by interacting with cytoskeletal proteins such as SPTBN1.

  7. Results suggest that it is possible for cellular proteins to differentially associate with the C-termini of different beta-spectrin isoforms to regulate alpha- and beta-spectrin association to form functional spectrin tetramers.

  8. Results suggest that epigenetic silencing of SPTBN1 (beta2SP) is a new potential causal factor in BWS (show CDKN1C Antibodies) patients.

  9. reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene

  10. High affinity and slow overall kinetics of association/dissociation of beta II-spectrin may suit it well to a role in strengthening cell junctions and providing stable anchorage for transmembrane proteins at points specified by cell-adhesion molecules.

SPTBN1 Antigen Profile

Protein Summary

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPTBN1

  • spectrin beta, non-erythrocytic 1 (Sptbn1) antibody
  • spectrin, beta, non-erythrocytic 1 (SPTBN1) antibody
  • spectrin, beta, non-erythrocytic 1 (Sptbn1) antibody
  • 9930031C03Rik antibody
  • AL033301 antibody
  • betaSpII antibody
  • ELF antibody
  • elf1 antibody
  • elf3 antibody
  • mKIAA4049 antibody
  • Spnb-2 antibody
  • Spnb1 antibody
  • Spnb2 antibody
  • SPTB2 antibody

Protein level used designations for SPTBN1

beta fodrin , beta-II spectrin , beta-spectrin 2, non-erythrocytic , brain spectrin , embryonic liver fodrin , fodrin beta chain , non-erythrocytic , spectrin G , spectrin beta 2 , spectrin beta chain, brain 1 , spectrin beta chain, non-erythrocytic 1 , spectrin, non-erythroid beta chain 1 , beta-G spectrin , beta-fodrin , beta-spectrin 2 , beta-spectrin II , beta-spectrin non-erythrocytic 1 , embryonic liver beta-fodrin , bSPII- , beta II spectrin-like (short form) , cytoskeleton protein , non-erythroid spectrin beta , short form of beta II spectrin

GENE ID SPECIES
20742 Mus musculus
6711 Homo sapiens
305614 Rattus norvegicus
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