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Sphingosine Kinase 1 Proteins (SPHK1)

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (173) and Sphingosine Kinase 1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top Sphingosine Kinase 1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$950.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Sf-9 Cells Human His tag   10 μg Log in to see 4 to 6 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,125.10
Details

SPHK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Sphingosine Kinase 1 (SPHK1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (show MBTPS1 Proteins) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sphk1 plays an important role in the malignant transformation of breast epithelial cells and modulates breast cancer metastasis through the regulation of Ecadherin expression.

  2. SPHK1 is involved in tumor development and progression of cervical cancer

  3. The silencing of SphK1 potentiated the apoptotic effects of the green tea polyphenol epigallocatechin-3-O-gallate.

  4. increased SK and SPL (show SGPL1 Proteins) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  5. Hepatitis B virus X protein is able to elevate the expression of SPHK1 in hepatoma cells by upregulating transcription factor AP2 alpha (show TFAP2A Proteins).

  6. In summary, this study demonstrates a link between SphK1/sphingosine-1-phosphate and TGF-beta (show TGFB1 Proteins)-induced miR (show MLXIP Proteins)-21 in renal tubular epithelial cells.

  7. High SPHK1 protein correlated with resistance to cisplatin (IC50) in an independent gastric cancer cell line panel and with survival of patients treated with chemotherapy prior to surgery but not in patients treated with surgery alone.

  8. MiR (show MLXIP Proteins)-506 suppresses the angiogenesis of liver cancer by inhibiting SPHK1.

  9. Resveratrol-induced proliferation inhibition of K562 cells might be mediated through its modulation activity of SphK1 pathway by regulating S1P (show MBTPS1 Proteins) and ceramide levels, which then affected the proliferation and apoptosis process of leukemia cells.

  10. Results reveal an lncRNA- and E2F1 (show E2F1 Proteins)-driven regulatory loop in which E2F1 (show E2F1 Proteins)-dependent induction of antisense RNA leads to changes in chromatin structure, facilitating E2F1 (show E2F1 Proteins)-dependent expression of SPHK1 and restriction of E2F1 (show E2F1 Proteins)-induced apoptosis.

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.

  2. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

  3. Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.

  4. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Proteins)-SphK1 signaling.

  5. The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG Proteins) involved in the pathogenesis of hepatocellular steatosis.

  6. Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.

  7. The results of this study indicated that Sphk1 plays an essential role in mediating post-stroke neuroinflammation.

  8. Prolonged lowering of plasma S1P, using sphingosine kinase inhibitor, produces pro-atherogenic effects in LDL-R-/- mice that are evident under condition of pronounced hypercholesterolemia.

  9. study provides new insights into the role of SphK1 in hepatocyte survival and uncovers a novel mechanism for protection against ER stress-mediated cell death.

  10. oxLDL induced angiogenesis requires SPHK1/S1P (show S1PR1 Proteins) signalling both in vitro in a HMEC-1 tube formation model and in vivo in the murine Matrigel plug model

Sphingosine Kinase 1 (SPHK1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sphingosine Kinase 1 Proteins (SPHK1)

  • Sphingosine kinase 1 (Sk1)
  • sphingosine kinase 1 (SPHK1)
  • sphingosine kinase 1 (sphk1)
  • sphingosine kinase 1 (LOC100357790)
  • sphingosine kinase 1 (Sphk1)
  • 1110006G24Rik protein
  • CG1747 protein
  • Dmel\\CG1747 protein
  • F18E5.160 protein
  • F18E5_160 protein
  • Sk1 protein
  • sphingosine kinase 1 protein
  • SPHK protein
  • SPHK1 protein
  • Spk1 protein

Protein level used designations for Sphingosine Kinase 1 Proteins (SPHK1)

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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