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Sphingosine Kinase 1 Proteins (SPHK1)

The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (199) and Sphingosine Kinase 1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPHK1 8877 Q9NYA1
SPHK1 20698 Q8CI15
SPHK1 170897 Q91V26
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Top Sphingosine Kinase 1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$338.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$950.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,054.33
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Sf-9 Cells Human His tag   10 μg Log in to see 4 to 6 Days
$397.10
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$983.13
Details

SPHK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for Sphingosine Kinase 1 (SPHK1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila

Arabidopsis thaliana Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SPHK/phyto-S1P (show MBTPS1 Proteins) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.

  2. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.

Human Sphingosine Kinase 1 (SPHK1) interaction partners

  1. SphK1 is associated with the proliferation and invasiveness of CRC (show CALR Proteins) cells and the SphK1 gene may contribute to a novel therapeutic approach against CRC (show CALR Proteins).

  2. The levels of SphK1 were significantly increased in triple-negative breast cancer patients compared with normal controls. SphK1 knockdown with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion, suggesting that SphK1 has an important role in TNBC.

  3. SPHK1 mRNA is up-regulation in colorectal cancer.

  4. Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.

  5. In conclusion, these data suggested that HuR (show ELAVL1 Proteins) bound to SphK1 mRNA and played a crucial role in TGF-beta1 (show TGFB1 Proteins)-induced hepatic stellate cell activation.

  6. low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 Proteins)-induced activation of the neutral sphingomyelinase-2 (show SMPD3 Proteins)/sphingosine kinase-1 pathway, and is effectively inhibited by GW4869.

  7. SphK1 expression is functionally associated to cellular proliferation, apoptosis, invasion and mitotane sensitivity of adrenocortical carcinoma.

  8. Data show that long non-coding RNA HULC promotes tumor angiogenesis in liver cancer through microRNA miR (show MLXIP Proteins)-107/E2F1 transcription factor (E2F1 (show E2F1 Proteins))/sphingosine kinase 1 (SPHK1) signaling.

  9. High SPHK1 expression is associated with ovarian cancer.

  10. Sphk1 plays an important role in the malignant transformation of breast epithelial cells and modulates breast cancer metastasis through the regulation of Ecadherin expression.

Mouse (Murine) Sphingosine Kinase 1 (SPHK1) interaction partners

  1. These findings suggest that the inhibitory effect of these plant extracts on the activation of AGEs/RAGE (show AGER Proteins)/SphK1 signaling pathway in db/db (show LEPR Proteins) diabetic mice kidney is a novel mechanism by which they exert renoprotective effects in diabetic nephropathy.

  2. Keratinocyte-specific deletion of Traf2 (show TRAF2 Proteins), but not Sphk1 deficiency, disrupted TNF (show TNF Proteins) mediated NF-kappaB (show NFKB1 Proteins) and MAP kinase (show MAPK1 Proteins) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.

  3. SphK1 dependent PKC-delta (show PKCd Proteins) activation plays an important role in promoting NF-kappaB (show NFKB1 Proteins) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd Proteins) activation might be a potential therapeutic strategy for this disease.

  4. Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 Proteins) cytoplasmic translocation in liver cells.

  5. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.

  6. transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists

  7. Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.

  8. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Proteins)-SphK1 signaling.

  9. The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG Proteins) involved in the pathogenesis of hepatocellular steatosis.

  10. Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.

Sphingosine Kinase 1 (SPHK1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Sphingosine Kinase 1 Proteins (SPHK1)

  • Sphingosine kinase 1 (Sk1)
  • sphingosine kinase 1 (SPHK1)
  • sphingosine kinase 1 (sphk1)
  • sphingosine kinase 1 (LOC100357790)
  • sphingosine kinase 1 (Sphk1)
  • 1110006G24Rik protein
  • CG1747 protein
  • Dmel\\CG1747 protein
  • F18E5.160 protein
  • F18E5_160 protein
  • Sk1 protein
  • sphingosine kinase 1 protein
  • SPHK protein
  • SPHK1 protein
  • Spk1 protein

Protein level used designations for Sphingosine Kinase 1 Proteins (SPHK1)

CG1747-PA , CG1747-PB , Sk1-PA , Sk1-PB , sphingosine kinase 1 , sphingosine kinase I , SK 1 , SPK 1

GENE ID SPECIES
32089 Drosophila melanogaster
427803 Gallus gallus
495437 Xenopus laevis
738821 Pan troglodytes
828239 Arabidopsis thaliana
100058875 Equus caballus
100357790 Oryctolagus cuniculus
8877 Homo sapiens
20698 Mus musculus
618605 Bos taurus
170897 Rattus norvegicus
483329 Canis lupus familiaris
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