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The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (173) and Sphingosine Kinase 1 Kits (6) and many more products for this protein.
Showing 10 out of 13 products:
Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (show MBTPS1 Proteins) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
SPHK1 is involved in tumor development and progression of cervical cancer
The silencing of SphK1 potentiated the apoptotic effects of the green tea polyphenol epigallocatechin-3-O-gallate.
increased SK and SPL (show SGPL1 Proteins) mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
Hepatitis B virus X protein is able to elevate the expression of SPHK1 in hepatoma cells by upregulating transcription factor AP2 alpha (show TFAP2A Proteins).
In summary, this study demonstrates a link between SphK1/sphingosine-1-phosphate and TGF-beta (show TGFB1 Proteins)-induced miR (show MLXIP Proteins)-21 in renal tubular epithelial cells.
High SPHK1 protein correlated with resistance to cisplatin (IC50) in an independent gastric cancer cell line panel and with survival of patients treated with chemotherapy prior to surgery but not in patients treated with surgery alone.
MiR (show MLXIP Proteins)-506 suppresses the angiogenesis of liver cancer by inhibiting SPHK1.
Resveratrol-induced proliferation inhibition of K562 cells might be mediated through its modulation activity of SphK1 pathway by regulating S1P (show MBTPS1 Proteins) and ceramide levels, which then affected the proliferation and apoptosis process of leukemia cells.
Results reveal an lncRNA- and E2F1 (show E2F1 Proteins)-driven regulatory loop in which E2F1 (show E2F1 Proteins)-dependent induction of antisense RNA leads to changes in chromatin structure, facilitating E2F1 (show E2F1 Proteins)-dependent expression of SPHK1 and restriction of E2F1 (show E2F1 Proteins)-induced apoptosis.
In contrast to the SK activity, S1PP activity was homogeneous across the peripheral blood NK cells, suggesting a bias in the SK pathway towards proliferation and migration, activities supported by S1P (show MBTPS1 Proteins).
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists
Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Proteins)-SphK1 signaling.
The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG Proteins) involved in the pathogenesis of hepatocellular steatosis.
Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.
The results of this study indicated that Sphk1 plays an essential role in mediating post-stroke neuroinflammation.
Prolonged lowering of plasma S1P, using sphingosine kinase inhibitor, produces pro-atherogenic effects in LDL-R-/- mice that are evident under condition of pronounced hypercholesterolemia.
study provides new insights into the role of SphK1 in hepatocyte survival and uncovers a novel mechanism for protection against ER stress-mediated cell death.
oxLDL induced angiogenesis requires SPHK1/S1P (show S1PR1 Proteins) signalling both in vitro in a HMEC-1 tube formation model and in vivo in the murine Matrigel plug model
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1