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The protein encoded by SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Additionally we are shipping Sphingosine Kinase 1 Antibodies (192) and Sphingosine Kinase 1 Kits (7) and many more products for this protein.
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Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
SPHK/phyto-S1P (show MBTPS1 Proteins) and PLDalpha1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis.
Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase.
SPHK1 mRNA is up-regulation in colorectal cancer.
Found that upregulation of SphK1 expression in the stiff substrate is dominant in metastatic cancer cells but not in primary cancer cells. These results suggest that alterations in the mechanical environment of the extracellular matrix surrounding the tumor cells actively regulate cellular properties such as secretion, which in turn, may contribute to cancer progression.
In conclusion, these data suggested that HuR (show ELAVL1 Proteins) bound to SphK1 mRNA and played a crucial role in TGF-beta1 (show TGFB1 Proteins)-induced hepatic stellate cell activation.
low oxLDL concentration triggers sprouting angiogenesis that involves ROS (show ROS1 Proteins)-induced activation of the neutral sphingomyelinase-2 (show SMPD3 Proteins)/sphingosine kinase-1 pathway, and is effectively inhibited by GW4869.
SphK1 expression is functionally associated to cellular proliferation, apoptosis, invasion and mitotane sensitivity of adrenocortical carcinoma.
Data show that long non-coding RNA HULC promotes tumor angiogenesis in liver cancer through microRNA miR (show MLXIP Proteins)-107/E2F1 transcription factor (E2F1 (show E2F1 Proteins))/sphingosine kinase 1 (SPHK1) signaling.
High SPHK1 expression is associated with ovarian cancer.
Sphk1 plays an important role in the malignant transformation of breast epithelial cells and modulates breast cancer metastasis through the regulation of Ecadherin expression.
SPHK1 is involved in tumor development and progression of cervical cancer
The silencing of SphK1 potentiated the apoptotic effects of the green tea polyphenol epigallocatechin-3-O-gallate.
Keratinocyte-specific deletion of Traf2 (show TRAF2 Proteins), but not Sphk1 deficiency, disrupted TNF (show TNF Proteins) mediated NF-kappaB (show NFKB1 Proteins) and MAP kinase (show MAPK1 Proteins) signalling and caused epidermal hyperplasia and psoriatic skin inflammation.
SphK1 dependent PKC-delta (show PKCd Proteins) activation plays an important role in promoting NF-kappaB (show NFKB1 Proteins) activation and inflammatory response in acute liver failure, and inhibition of PKC-delta (show PKCd Proteins) activation might be a potential therapeutic strategy for this disease.
Inhibition of SphK1 ameliorates drug-induced acute liver failure by reducing HMGB1 (show HMGB1 Proteins) cytoplasmic translocation in liver cells.
Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo.
transient receptor potential channel 1 suppression of basal sphingosine kinase 1 activity enables endothelial cell-barrier destabilization by edemagenic agonists
Based on these findings, the authors propose new roles for SK1 in affecting innate responses that regulate susceptibility to dengue virus infection.
Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Proteins)-SphK1 signaling.
The study demonstrates a new pathway connecting SphK1 and PPARgamma (show PPARG Proteins) involved in the pathogenesis of hepatocellular steatosis.
Inhibition of SK1 attenuates the second phase of transmembrane Calcium influx.
The results of this study indicated that Sphk1 plays an essential role in mediating post-stroke neuroinflammation.
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, sphingosine kinase 1
, sphingosine kinase I
, SK 1
, SPK 1