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Sphingosine-1-Phosphate Lyase 1 Proteins (SGPL1)

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Additionally we are shipping SGPL1 Antibodies (42) and SGPL1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SGPL1 20397 Q8R0X7
SGPL1 8879 O95470
Rat SGPL1 SGPL1 286896 Q8CHN6
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Top SGPL1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SGPL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , , ,
, ,

More Proteins for Sphingosine-1-Phosphate Lyase 1 (SGPL1) Interaction Partners

Mouse (Murine) Sphingosine-1-Phosphate Lyase 1 (SGPL1) interaction partners

  1. Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.

  2. Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.

  3. upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P (show S1PR1 Proteins) lyase-deficient MEFs

  4. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Proteins)-activated microRNAs.

  5. Findings suggest that sphingosine phosphate lyase (S1P (show S1PR1 Proteins) lyase) expressed in the thymic medullary perivascular spaces keeps the tissue sphingosine 1-phosphate low around the vessels and promotes thymic egress via up-regulation of S1P receptor 1 (S1P1 (show S1PR1 Proteins)).

  6. Data indicate that SGPL1 sphingosine 1-phosphate lyase (aldolase) mRNA is significantly increased in the periinfarct cortex.

  7. Leukocyte Sgpl1 as critical factor in monocyte macrophage differentiation and function.

  8. Inducible Sgpl1 knockout mice are protected in experimental autoimmune encephalomyelitis (EAE).

  9. S1PL deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.

  10. Data show that S1P (show S1PR1 Proteins) lyase knockout mice with reduced S1P (show S1PR1 Proteins) lyase activity (resulting in increased bio-available S1P (show S1PR1 Proteins)) had improved survival compared with wild-type littermates.

Human Sphingosine-1-Phosphate Lyase 1 (SGPL1) interaction partners

  1. increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.

  2. SPHK1 (show SPHK1 Proteins):SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)), and S1P (show MBTPS1 Proteins) correlated with drug resistance (IC50).

  3. Results show that dissociation of SHP-1 (show PTPN6 Proteins) from spinophilin (show PPP1R9B Proteins) is followed by an increase in the binding of spinophilin (show PPP1R9B Proteins) to PP1 (show PPA1 Proteins).

  4. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Proteins)-activated microRNAs.

  5. S1P (show MBTPS1 Proteins) lyase - by facilitating S1P1 (show S1PR1 Proteins) receptor recycling - is essential for S1P (show MBTPS1 Proteins)-mediated sustained signaling

  6. results highlight the importance of S1P (show MBTPS1 Proteins) in AD suggesting the existence of a global deregulation of S1P (show MBTPS1 Proteins) signaling in this disease from its synthesis by SphK1 (show SPHK1 Proteins) and degradation by SPL to its signaling by the S1P1 (show S1PR1 Proteins) receptor.

  7. The cells expressing SGPL1 in the parenchyma were CD68 (show CD68 Proteins)(+) APCs (show APCS Proteins).

  8. Data show that a easy assay for 2-hydroxyacyl-CoA lyase (HACL1 (show HACL1 Proteins)) and sphingosine-1-phosphate lyase (SGPL1) activities was developed.

  9. SPL expression and activity are downregulated in cancerous tissues, there is a relationship between loss of SPL expression and prostate cancer aggressiveness.

  10. S1P (show MBTPS1 Proteins)(ext (show EXT1 Proteins)) mediated endothelial cell motility is dependent on intracellular S1P (show MBTPS1 Proteins) production, which is regulated, in part, by SphK1 (show SPHK1 Proteins) and S1PL.

SGPL1 Protein Profile

Protein Summary

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

Gene names and symbols associated with SGPL1

  • sphingosine-1-phosphate lyase 1 (SGPL1)
  • sphingosine-1-phosphate lyase 1 (sgpl1)
  • sphingosine phosphate lyase 1 (Sgpl1)
  • sphingosine-1-phosphate lyase 1 (Sgpl1)
  • AI428538 protein
  • D10Xrf456 protein
  • S1PL protein
  • SGPL1 protein
  • Spgl1 protein
  • spl protein
  • zgc:162153 protein

Protein level used designations for SGPL1

sphingosine-1-phosphate lyase 1 , spl , SP-lyase 1 , SPL 1 , mSPL , sphingosine-1-phosphate aldolase , hSPL , sphingosine phosphate lyase 1

GENE ID SPECIES
100072755 Equus caballus
423714 Gallus gallus
100037007 Xenopus laevis
100037312 Danio rerio
20397 Mus musculus
8879 Homo sapiens
522515 Bos taurus
286896 Rattus norvegicus
489032 Canis lupus familiaris
100525187 Sus scrofa
100173995 Pongo abelii
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