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Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Additionally we are shipping SGPL1 Antibodies (42) and SGPL1 Kits (9) and many more products for this protein.
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Studies suggest that S1PL is a novel endogenous suppressor of pulmonary fibrosis in human idiopathic pulmonary fibrosis and animal models.
Although the observed inhibitory effect was not as strong as that of 4-deoxypyridoxine (a VB6 analog SPL inhibitor), these findings may be useful for further understanding the mechanism of action of THI.
upregulation of multidrug resistance transporters contributes to the chemoresistance of S1P (show S1PR1 Proteins) lyase-deficient MEFs
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3 (show STAT3 Proteins)-activated microRNAs.
Findings suggest that sphingosine phosphate lyase (S1P (show S1PR1 Proteins) lyase) expressed in the thymic medullary perivascular spaces keeps the tissue sphingosine 1-phosphate low around the vessels and promotes thymic egress via up-regulation of S1P receptor 1 (S1P1 (show S1PR1 Proteins)).
Data indicate that SGPL1 sphingosine 1-phosphate lyase (aldolase) mRNA is significantly increased in the periinfarct cortex.
Leukocyte Sgpl1 as critical factor in monocyte macrophage differentiation and function.
Inducible Sgpl1 knockout mice are protected in experimental autoimmune encephalomyelitis (EAE).
S1PL deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons.
Data show that S1P (show S1PR1 Proteins) lyase knockout mice with reduced S1P (show S1PR1 Proteins) lyase activity (resulting in increased bio-available S1P (show S1PR1 Proteins)) had improved survival compared with wild-type littermates.
increased SK and SPL mRNA expression along with reduced sphingosine 1-phosphate levels were more commonly observed in hepatocellular carcinoma tissues.
SPHK1 (show SPHK1 Proteins):SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)), and S1P (show MBTPS1 Proteins) correlated with drug resistance (IC50).
Results show that dissociation of SHP-1 (show PTPN6 Proteins) from spinophilin (show PPP1R9B Proteins) is followed by an increase in the binding of spinophilin (show PPP1R9B Proteins) to PP1 (show PPA1 Proteins).
S1P (show MBTPS1 Proteins) lyase - by facilitating S1P1 (show S1PR1 Proteins) receptor recycling - is essential for S1P (show MBTPS1 Proteins)-mediated sustained signaling
results highlight the importance of S1P (show MBTPS1 Proteins) in AD suggesting the existence of a global deregulation of S1P (show MBTPS1 Proteins) signaling in this disease from its synthesis by SphK1 (show SPHK1 Proteins) and degradation by SPL to its signaling by the S1P1 (show S1PR1 Proteins) receptor.
The cells expressing SGPL1 in the parenchyma were CD68 (show CD68 Proteins)(+) APCs (show APCS Proteins).
Data show that a easy assay for 2-hydroxyacyl-CoA lyase (HACL1 (show HACL1 Proteins)) and sphingosine-1-phosphate lyase (SGPL1) activities was developed.
SPL expression and activity are downregulated in cancerous tissues, there is a relationship between loss of SPL expression and prostate cancer aggressiveness.
S1P (show MBTPS1 Proteins)(ext (show EXT1 Proteins)) mediated endothelial cell motility is dependent on intracellular S1P (show MBTPS1 Proteins) production, which is regulated, in part, by SphK1 (show SPHK1 Proteins) and S1PL.
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
sphingosine-1-phosphate lyase 1
, SP-lyase 1
, SPL 1
, sphingosine-1-phosphate aldolase
, sphingosine phosphate lyase 1