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Sphingosine-1-Phosphate Receptor 2 Proteins (S1PR2)

S1PR2 encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. Additionally we are shipping S1PR2 Antibodies (50) and S1PR2 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
S1PR2 9294 O95136
S1PR2 14739 P52592
Rat S1PR2 S1PR2 29415 P47752
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Top S1PR2 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

S1PR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Sphingosine-1-Phosphate Receptor 2 (S1PR2) Interaction Partners

Human Sphingosine-1-Phosphate Receptor 2 (S1PR2) interaction partners

  1. Sphingosine 1-phosphate-induced IL-8 (show IL8 Proteins) gene expression is mainly regulated via S1PR(1 (show S1PR1 Proteins)), and its secretion is regulated through S1PR(2) receptor subtype.

  2. S1PR2 is repressed by FOXP1 (show FOXP1 Proteins) in activated B-cell and germinal center B-cell DLBCL cell lines with aberrantly high FOXP1 (show FOXP1 Proteins) levels; S1PR2 expression is further inversely correlated with FOXP1 (show FOXP1 Proteins) expression in 3 DLBCL patient cohorts.

  3. LXR-alpha (show NR1H3 Proteins) might downregulate S1PR2 expression via miR (show MLXIP Proteins)-130a-3p in quiescent HUVECs. Stimulation of TNF-alpha (show TNF Proteins) attenuates the activity of LXR-alpha (show NR1H3 Proteins) and results in enhanced S1PR2 expression.

  4. S1PR2 plays a critical role in TCA-induced COX-2 expression and CCA (show FBN2 Proteins) growth and may represent a novel therapeutic target for CCA (show FBN2 Proteins).

  5. both S1PR1 (show S1PR1 Proteins) and S1PR2 play a pivotal role in hyperglycemia-induced EC dysfunction and endothelial injury by reducing and enhancing the production of oxidative stress.

  6. AB1 displayed potency at least equivalent to JTE-013 in affecting signaling molecules downstream of S1P2.

  7. Activation of S1PR2-calcium influx-RhoA (show RHOA Proteins)/ROCK dominates the high-dose S1P (show MBTPS1 Proteins)-induced endothelial monolayer hyperpermeability response.

  8. Data show that sphingosine kinase SphK1 (show SPHK1 Proteins) and sphingosine-1-phosphate (S1P (show MBTPS1 Proteins)) receptors S1P1 (show S1PR1 Proteins), S1P2, S1P3 (show S1PR3 Proteins), and S1P5 (show S1PR5 Proteins) were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 (show SPHK2 Proteins) levels were highest in primary tumors.

  9. Data indicate that sphingosine 1-phosphate (S1P (show MBTPS1 Proteins)) and hepatocyte growth factor (HGF (show HGF Proteins)) induced transloaction of integrin beta4, S1P (show MBTPS1 Proteins) receptors S1PR2 and S1PR3 (show S1PR3 Proteins) to endothelial cell membrane caveolin-enriched microdomains (CEMs).

  10. The S1P2R specifically activates RhoC (show RHOC Proteins) via G12 (show TCF3 Proteins)/13 proteins and LARG (show ARHGEF12 Proteins).

Mouse (Murine) Sphingosine-1-Phosphate Receptor 2 (S1PR2) interaction partners

  1. S1P2 receptor is a key signaling molecule in the S1Pdependent inhibition of adipogenic differentiation.

  2. S1PR2, as a critical receptor in macrophages, impairs phagocytosis and antimicrobial defense in the pathogenesis of sepsis.

  3. These results suggest that S1PR2 and CXCR5 (show CXCR5 Proteins) cooperatively regulate localization of Tfh cells in GCs (show UGCG Proteins) to support GC responses

  4. The sphingolipid receptor S1PR2 is a receptor for Nogo-a (show RTN4 Proteins) repressing synaptic plasticity.

  5. S1PR2 expression was increased in disease-susceptible regions of the CNS of female SJL EAE mice compared with their male counterparts.

  6. IL-6 (show IL6 Proteins) increased the number of osteoclast precursor cells in tibial bone marrow via up-regulating S1PR2, thus playing a crucial role in systemic bone loss induced by inflammation.

  7. Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase (show NOS3 Proteins) in mice.

  8. Data show that two S1P (show S1PR1 Proteins) receptors, S1P2 and S1P3 (show S1PR3 Proteins), are collectively essential mediators of eyelid closure during murine development.

  9. S1PR2 is a key regulator of the proinflammatory phenotype of the endothelium.

  10. S1PR2 is dispensable for initiating IgE/Ag-mediated connective tissue mast cell degranulation and anaphylaxis, but it is required for normal recovery from anaphylaxis.

S1PR2 Protein Profile

Protein Summary

This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation

Gene names and symbols associated with S1PR2

  • sphingosine-1-phosphate receptor 2 (S1PR2)
  • sphingosine-1-phosphate receptor 2 (S1pr2)
  • 1100001A16Rik protein
  • AGR16 protein
  • EDG-5 protein
  • Edg5 protein
  • Gpcr13 protein
  • GPCR18 protein
  • H218 protein
  • LPb2 protein
  • S1P2 protein
  • snGPCR18 protein

Protein level used designations for S1PR2

sphingosine-1-phosphate receptor 2 , sphingosine 1-phosphate receptor 2-like , S1P receptor 2 , S1P receptor EDG5 , S1P receptor Edg-5 , endothelial differentiation G-protein coupled receptor 5 , endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 , sphingosine 1-phosphate receptor 2 , sphingosine 1-phosphate receptor Edg-5 , G-protein coupled receptor 13 , lysophospholipid receptor B2 , sphingosine-1-phosphate receptor S1P(2) , AGR16 , G-protein coupled receptor H218 , S1P2

100392405 Callithrix jacchus
100435839 Pongo abelii
100610932 Pan troglodytes
9294 Homo sapiens
14739 Mus musculus
29415 Rattus norvegicus
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