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Sphingosine-1-Phosphate Receptor 4 Proteins (S1PR4)

S1PR4 is a member of the endothelial differentiation, G-protein-coupled EDG receptor gene family. Additionally we are shipping S1PR4 Antibodies (100) and S1PR4 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
S1PR4 8698 O95977
S1PR4 13611 Q9Z0L1
Rat S1PR4 S1PR4 314649  
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Top S1PR4 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

S1PR4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Sphingosine-1-Phosphate Receptor 4 (S1PR4) Interaction Partners

Human Sphingosine-1-Phosphate Receptor 4 (S1PR4) interaction partners

  1. Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7 (show TLR7 Proteins)/9 ligands to allow high IFN-alpha (show IFNA Proteins) production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha (show IFNA Proteins) secretion.

  2. S1P2 (show S1PR2 Proteins) translocation to the nucleus is regulated by an autocrine loop involving S1P (show MBTPS1 Proteins) and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src (show SRC Proteins) to the nucleus appears to be regulated by a mechanism that does not involve S1P3 (show S1PR3 Proteins) or S1P4.

  3. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P (show MBTPS1 Proteins)-R) agonists

  4. findings highlight an important role for S1P (show MBTPS1 Proteins)(4) and SK1 in ER(-) breast cancer progression.

  5. Data show that S1P4 uses HER2 (show ERBB2 Proteins) to regulate extracellular signal regulated kinase-1/2 (show MAPK3 Proteins) MDA-MB-453 breast cancer cells.

  6. Data report that sphingosine 1-ph (show MBTPS1 Proteins)osphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells

  7. Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species

  8. FOXO1 (show FOXO1 Proteins) controls the expression of L-selectin (show SELL Proteins) and EDG1 (show HEXIM1 Proteins) and EDG6, receptors that regulate lymphocyte trafficking

Mouse (Murine) Sphingosine-1-Phosphate Receptor 4 (S1PR4) interaction partners

  1. Data shows a reduced abundance of pDC (show PDC Proteins), particularly CD4 (show CD4 Proteins)- pDC (show PDC Proteins), in all organs of S1PR4-deficient vs. wildtype mice.

  2. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P (show S1PR1 Proteins)-R) agonists

  3. S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P (show S1PR1 Proteins) signaling also modifies the course of various immune diseases in a murine model

  4. Megakaryocytes generated from S1P (show S1PR1 Proteins)(4)-deficient murine bone marrow showed atypical and reduced formation of proplatelets in vitro.

  5. s1p(4) maps to mouse chromosome 10 and has similar tissue distribution to mouse Gna15; transcription of the two genes may be under control of the same enhancer elements

  6. binding pocket of mS1P4 (mouse S1P4) has recognition sites for the anionic phosphate and cationic ammonium groups that are equidistant from the end of the non-polar tail

  7. S1P4 mediates immunosuppressive effects of S1P (show S1PR1 Proteins) by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10 (show IL10 Proteins)

S1PR4 Protein Profile

Protein Summary

This gene is a member of the endothelial differentiation, G-protein-coupled EDG receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.

Gene names and symbols associated with S1PR4

  • sphingosine-1-phosphate receptor 4 (S1PR4)
  • sphingosine-1-phosphate receptor 4 (s1pr4)
  • sphingosine-1-phosphate receptor 4 (S1pr4)
  • Edg6 protein
  • Lpc1 protein
  • S1p4 protein
  • SLP4 protein

Protein level used designations for S1PR4

endothelial differentiation, G protein coupled receptor 6 , endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6 , sphingosine 1-phosphate receptor 4 , sphingosine-1-phosphate receptor 4 , S1P receptor 4 , S1P receptor Edg-6 , endothelial differentiation G-protein coupled receptor 6 , endothelial differentiation, G-protein-coupled receptor 6 , sphingosine 1-phosphate receptor Edg-6 , S1p receptor 4 , endothelial differentiation G-protein-coupled receptor 6 , lysophospholipid receptor C1 , endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6

GENE ID SPECIES
455581 Pan troglodytes
539534 Bos taurus
612082 Canis lupus familiaris
712637 Macaca mulatta
100380986 Xenopus laevis
8698 Homo sapiens
13611 Mus musculus
314649 Rattus norvegicus
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