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S1PR4 is a member of the endothelial differentiation, G-protein-coupled EDG receptor gene family. Additionally we are shipping S1PR4 Kits (12) and S1PR4 Proteins (4) and many more products for this protein.
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Human Polyclonal S1PR4 Primary Antibody for WB - ABIN652182
Contos, Ye, Sah, Chun: Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene. in FEBS letters 2002
Show all 4 Pubmed References
S1PR4 missense mutation is associated with variant blood cell traits.
Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs.
Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7 (show TLR7 Antibodies)/9 ligands to allow high IFN-alpha (show IFNA Antibodies) production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha (show IFNA Antibodies) secretion.
S1P2 (show S1PR2 Antibodies) translocation to the nucleus is regulated by an autocrine loop involving S1P (show MBTPS1 Antibodies) and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src (show SRC Antibodies) to the nucleus appears to be regulated by a mechanism that does not involve S1P3 (show S1PR3 Antibodies) or S1P4.
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P (show MBTPS1 Antibodies)-R) agonists
findings highlight an important role for S1P (show MBTPS1 Antibodies)(4) and SK1 (show KCNN1 Antibodies) in ER(-) breast cancer progression.
Data show that S1P4 uses HER2 (show ERBB2 Antibodies) to regulate extracellular signal regulated kinase-1/2 (show MAPK3 Antibodies) MDA-MB-453 breast cancer cells.
Data report that sphingosine 1-ph (show MBTPS1 Antibodies)osphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells
Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species
FOXO1 (show FOXO1 Antibodies) controls the expression of L-selectin (show SELL Antibodies) and EDG1 (show HEXIM1 Antibodies) and EDG6, receptors that regulate lymphocyte trafficking
Data shows a reduced abundance of pDC (show PDC Antibodies), particularly CD4 (show CD4 Antibodies)- pDC (show PDC Antibodies), in all organs of S1PR4-deficient vs. wildtype mice.
analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P (show S1PR1 Antibodies)-R) agonists
S1P4 signaling is involved in the regulation of dendritic cell function and TH17 T-cell differentiation. S1P4-mediated S1P (show S1PR1 Antibodies) signaling also modifies the course of various immune diseases in a murine model
Megakaryocytes generated from S1P (show S1PR1 Antibodies)(4)-deficient murine bone marrow showed atypical and reduced formation of proplatelets in vitro.
s1p (show S1PR1 Antibodies)(4) maps to mouse chromosome 10 and has similar tissue distribution to mouse Gna15 (show GNA15 Antibodies); transcription of the two genes may be under control of the same enhancer elements
binding pocket of mS1P4 (mouse S1P4) has recognition sites for the anionic phosphate and cationic ammonium groups that are equidistant from the end of the non-polar tail
S1P4 mediates immunosuppressive effects of S1P (show S1PR1 Antibodies) by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10 (show IL10 Antibodies)
This gene is a member of the endothelial differentiation, G-protein-coupled EDG receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue.
endothelial differentiation, G protein coupled receptor 6
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
, sphingosine 1-phosphate receptor 4
, sphingosine-1-phosphate receptor 4
, S1P receptor 4
, S1P receptor Edg-6
, endothelial differentiation G-protein coupled receptor 6
, endothelial differentiation, G-protein-coupled receptor 6
, sphingosine 1-phosphate receptor Edg-6
, S1p receptor 4
, endothelial differentiation G-protein-coupled receptor 6
, lysophospholipid receptor C1
, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 6