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The protein encoded by S1PR1 is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. Additionally we are shipping S1PR1 Kits (22) and S1PR1 Proteins (5) and many more products for this protein.
Showing 10 out of 187 products:
Human Polyclonal S1PR1 Primary Antibody for WB - ABIN264982
Liu, Wada, Yamashita, Mi, Deng, Hobson, Rosenfeldt, Nava, Chae, Lee, Liu, Hla, Spiegel, Proia: Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. in The Journal of clinical investigation 2000
Show all 9 references for ABIN264982
Human Polyclonal S1PR1 Primary Antibody for EIA, IHC (p) - ABIN358616
Dorsam, Graeler, Seroogy, Kong, Voice, Goetzl: Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor. in Journal of immunology (Baltimore, Md. : 1950) 2003
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Human Monoclonal S1PR1 Primary Antibody for FACS - ABIN4899114
Williams, Stilhano, To, Tran, Wong, Silva: Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). in PLoS ONE 2015
Show all 4 references for ABIN4899114
Human Polyclonal S1PR1 Primary Antibody for EIA, IHC (p) - ABIN500650
Miyasaka, Tanaka: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. in Nature reviews. Immunology 2004
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Mouse (Murine) Monoclonal S1PR1 Primary Antibody for FACS - ABIN4898837
Cuenca, Romero, Sintes, Terhorst, Engel: Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses. in Journal of immunology (Baltimore, Md. : 1950) 2016
Show all 3 references for ABIN4898837
Zebrafish (Danio rerio) Polyclonal S1PR1 Primary Antibody for WB - ABIN1881771
Im, Ungar, Lynch: Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. in Biochemical and biophysical research communications 2000
Human Polyclonal S1PR1 Primary Antibody for ICC, IF - ABIN4351831
Awojoodu, Ogle, Sefcik, Bowers, Martin, Brayman, Lynch, Peirce-Cottler, Botchwey: Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2013
Human Monoclonal S1PR1 Primary Antibody for FACS - ABIN4895626
Llinàs, Lázaro, de Salort, Matesanz-Isabel, Sintes, Engel: Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. in Immunology letters 2010
S1PR1 inhibits the apoptosis of human myeloid leukemia (show BCL11A Antibodies) cells and promotes their proliferation.
These results suggest that S1P (show MBTPS1 Antibodies) signaling plays a role in cell proliferation and drug resistance in multiple myeloma, and targeting this pathway will provide a new therapeutic direction for multiple myelomamanagement.
Sphingosine 1-phosphate-induced IL-8 (show IL8 Antibodies) gene expression is mainly regulated via S1PR(1), and its secretion is regulated through S1PR(2 (show S1PR2 Antibodies)) receptor subtype.
multiple lines of evidence demonstrate that S1PR1 signaling sets the sensitivity of pDC (show PNKD Antibodies) amplification of IFN responses, thereby blunting pathogenic immune responses
The results indicate that sphingosine 1-phosphate is involved in the migration of precursor T-cell lymphoblastic leukemia-lymphoma blasts in vitro, which is dependent on S1P1 expression.
Overexpression of miR148a or inhibition of S1PR1 suppressed SKOV3 cell migration and invasion, while restoration of S1PR1 expression reversed the suppressive effect of miR148a upregulation on SKOV3 cell migration and invasion.
the ability of ApoM (show APOM Antibodies)(+)HDL (show HSD11B1 Antibodies) to act as a biased agonist on S1P1 inhibits vascular inflammation, which may partially explain the cardiovascular protective functions of HDL (show HSD11B1 Antibodies).
S1P (show MBTPS1 Antibodies) receptor modulation reduces leukocyte migration across the endothelial barrier
SGPL1 (show SGPL1 Antibodies) ratio correlated with increased cellular sphingosine-1-phosphate (S1P (show MBTPS1 Antibodies)), and S1P (show MBTPS1 Antibodies) correlated with drug resistance (IC50).
Within lymphoid follicles, the S1P1 distribution pattern is complementary to that of CCR7 (show CCR7 Antibodies)/CXCR4 (show CXCR4 Antibodies), with strong immunoreactivity tightly restricted to mantle zone B cells. This may play a role in B-cell migration toward the S1p (show MBTPS1 Antibodies)-enriched follicle center.
S1P induced chemotaxis in M1 macrophages and changed cytokine production in M2 macrophages. Phagocytosis was not affected by S1P-signalling.
Data indicate that forkhead box F1 (Foxf1 (show FOXF1 Antibodies)) deletion from endothelial cells decreases the abundance of sphingosine 1-phosphate receptor 1 (S1PR1).
Study provided evidence for a role of S1P1 in regulating oligodendrocyte differentiation and developmental myelination
Galphas (show GNAS Antibodies) depletion blocks the S1PR1-activation induced VE-cadherin (show CDH5 Antibodies) stabilization at junctions.
S1P is localized in the presynaptic regions of mature neurons and is regulated by sphingosine-1-phosphate.
S1P1 receptor-selective up-regulation reduces the severity of acute graft versus host disease by inhibiting macrophage recruitment.
Early after VSV infection, WT and S1PR1(-/-) effector T cells localized exclusively within the lymph node paracortex. However, in contrast to WT, S1PR1(-/-) effector T cells failed to enter the sinuses.
GPER (show GPER Antibodies) and Gankyrin (show PSMD10 Antibodies) might be implicated in the hormonal regulation of endometriosis and be associated with the severity of endometriosis.
Sphingosine-1-Phosphate Receptor-1 Selective Agonist Enhances Collateral Growth and Protects against Subsequent Stroke.
Polymorphisms in promoter regions of PDHB (show PDHB Antibodies), SORBS1 (show SORBS1 Antibodies), and EDG1 genes showing marbling-associated expression changes.
we detected 2 novel SNPs, referred to as g.1475435G>A and g.1471620G>T, in the 5' flanking region of the EDG1 between low-marbled and high-marbled steer groups
EDG1 SNPs, although they may not be regarded as a causal mutation, may be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle.
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.
sphingosine-1-phosphate receptor 1
, sphingosine 1-phosphate receptor 1
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
, S1P receptor 1
, S1P receptor Edg-1
, endothelial differentiation G-protein coupled receptor 1
, sphingosine 1-phosphate receptor EDG1
, sphingosine 1-phosphate receptor Edg-1
, endothelial differentiation sphingolipid G-protein-coupled receptor 1
, lysophospholipid receptor B1
, EDG1 (Edg1)