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SPI1 encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. Additionally we are shipping Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 Proteins (9) and Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1 Kits (8) and many more products for this protein.
Showing 10 out of 150 products:
Human Polyclonal SPI1 Primary Antibody for EIA, WB - ABIN954927
Rimmelé, Komatsu, Hupé, Roulin, Barillot, Dutreix, Conseiller, Bensimon, Moreau-Gachelin, Guillouf: Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage. in Cancer research 2010
Show all 3 references for ABIN954927
Human Polyclonal SPI1 Primary Antibody for EIA, WB - ABIN375231
Uvarov, Ludwig, Markkanen, Rivera, Airaksinen: Upregulation of the neuron-specific K+/Cl- cotransporter expression by transcription factor early growth response 4. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Human Monoclonal SPI1 Primary Antibody for FACS, ELISA - ABIN3072909
Xu, Wang, Wang, Wu, Zhao, Zhu, Qiu, Xue, Shao, Guo, Li: PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60. in Leukemia research 2010
Chicken Polyclonal SPI1 Primary Antibody for WB - ABIN2777287
Lin, Rikihisa: Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and inhibits lipopolysaccharide activation of NF-kappa B, ERK 1/2 and p38 MAPK in host monocytes. in Cellular microbiology 2004
Human Polyclonal SPI1 Primary Antibody for ELISA, WB - ABIN1533640
Ray, Culine, Tavitain, Moreau-Gachelin: The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors. in Oncogene 1990
Chicken Polyclonal SPI1 Primary Antibody for WB - ABIN2780474
Crotti, Sharma, Fleming, Flannery, Ostrowski, Goldring, McHugh: PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter. in Journal of cellular physiology 2008
Chicken Polyclonal SPI1 Primary Antibody for WB - ABIN2780304
McDevit, Nikolajczyk: Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation. in Molecular immunology 2006
findings suggest that Gata1 (show GATA1 Antibodies) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
involved in osteoclast development by transactivating NFATc1 (show NFATC1 Antibodies) expression via direct binding to the NFATc1 (show NFATC1 Antibodies) promoter
GATA1 (show GATA1 Antibodies) and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (show RPS19 Antibodies) gene which is frequently mutated in Diamond-Blackfan Anemia.
PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 (show GATA3 Antibodies) Transcription in Dendritic Cells
Taken together, our results suggest that the expression of NDRG2 (show NDRG2 Antibodies) potentially inhibits osteoclast differentiation and plays a role in modulating the signal transduction pathway responsible for osteoclastogenesis.
Our results suggest that complementary biological functions of PU.1 and Spi-B (show SPIB Antibodies) may be explained by their interaction with a similar set of regions in the genome of B cells.
PU.1 keeps macrophage-specific genes accessible during differentiation by preventing Polycomb (show CBX2 Antibodies) repressive complex 2 binding to transcriptional regulatory elements.
Nfkb1 (show NFKB1 Antibodies) transcriptional activation by PU.1 and Spi-B (show SPIB Antibodies) promotes toll (show TLR4 Antibodies)-like receptor-mediated B cell proliferation.
These findings indicate that PU.1-mediated upregulation of CSF-1R (show CSF1R Antibodies) is a critical effector of MLL (show MLL Antibodies) leukemogenesis.
The Nogo-B (show RTN4 Antibodies)-PirB (show LILRB3 Antibodies) axis controls macrophage-mediated vascular remodeling.
Our results suggest the existence of a Vav1 (show VAV1 Antibodies)/PU.1/miR (show MLXIP Antibodies)-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia (show PML Antibodies) -derived cells
Our data suggest that E2A (show TCF3 Antibodies) antagonism of PU.1 activity contributes to its ability to commit multipotential hematopoietic progenitors to the lymphoid lineages.
This study showed that HCV infection might abrogate NK cytotoxic potential through altering PU.1, NKG2D (show KLRK1 Antibodies) receptor and perforin (show PRF1 Antibodies) molecules.
SPI1-GFI1B (show GFI1B Antibodies) transcriptional network is an important regulatory axis in acute myeloid leukemia (show BCL11A Antibodies) as well as in the development of erythroid versus myelomonocytic cell fate
The GATA-1-mediated inhibition of PU.1 gene transcription in human AML-erythroleukemias mediated through the URE represents important mechanism that contributes to PU.1 downregulation and leukemogenesis that is sensitive to DNA demethylation therapy
PU.1 downregulation was noted in B-CLL/SLL (show SLC35B2 Antibodies) samples positive for the adverse prognostic markers CD38 and ZAP-70 (show ZAP70 Antibodies).
This study demonstrated positive regulation of monocyte/macrophage differentiation by lnc-MC and uncovered an elaborate regulation mechanism composed of PU.1, lnc-MC, miR (show MLXIP Antibodies)-199a-5p, and ACVR1B (show ACVR1B Antibodies).
Collectively, IMiDs exert demethylation activity through inhibiting DNMT1 (show DNMT1 Antibodies), 3a, and 3b, and up-regulating PU.1 expression, which may be one of the mechanisms of the anti-myeloma activity of IMiDs.
PU.1 suppressive target gene, metallothionein 1G (show MT1G Antibodies), inhibits retinoic acid-induced NB4 cell differentiation.
A novel network has been described in acute myeloid leukemia (show BCL11A Antibodies) in which FLT3 (show FLT3 Antibodies)-ITD signaling induces oncogenic miR (show MLXIP Antibodies)-155 by p65 (show GORASP1 Antibodies) and STAT5 (show STAT5A Antibodies) thereby targeting transcription factor PU.1.
eaf1 (show EAF1 Antibodies) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (show GATA1 Antibodies) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (show ANPEP Antibodies) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (show RUNX1 Antibodies) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (show TRIM33 Antibodies) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (show GATA1 Antibodies) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal (show CAD Antibodies) LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
, contrapsin-like protease inhibitor 3
, contrapsin-like protease inhibitor-related protein
, liver regeneration protein lrryan
, serine protease inhibitor 1
, serine protease inhibitor 2.1
, serine protease inhibitor 2a
, serine protease inhibitor A3L
, serpin A3L
, 31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, Spi-1/PU.1 transcription factor
, transcription factor spi1