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StAR-Related Lipid Transfer (START) Domain Containing 4 Proteins (STARD4)

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1\; MIM 184756) and by liver X receptors (e.g., LXRA\; MIM 602423). Additionally we are shipping STARD4 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
STARD4 134429 Q96DR4
STARD4 170459 Q99JV5
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Top STARD4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

STARD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for StAR-Related Lipid Transfer (START) Domain Containing 4 (STARD4) Interaction Partners

Human StAR-Related Lipid Transfer (START) Domain Containing 4 (STARD4) interaction partners

  1. Studies show the 3 steroidogenic acute regulatory-related lipid transfer (START) domain proteins StarD4, StarD5 (show STARD5 Proteins) and StarD6 (show STARD6 Proteins) have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization.

  2. The data indicate a role for STARD4 in nonvesicular transport of cholesterol from the plasma membrane and the endocytic recycling compartment to the endoplasmic reticulum and perhaps other intracellular compartments as well.

  3. cholesterol transport mediated by STARD4 is an important component of the cholesterol homeostasis regulatory machinery

  4. Study provide strong evidence for StarD4 as a highly regulated, non-vesicular, directional, intracellular transporter of cholesterol which plays a key role in the maintenance of intracellular cholesterol homeostasis.

  5. StarD4-accelerated 7 alpha-OOH transfer to mitochondria resulted in greater susceptibility to free radical lipid peroxidation and loss of membrane potential than in a non-StarD4 control.

  6. StarD4 is regulated by sterols via SREBP-2 (show SREBF2 Proteins), and StarD5 (show STARD5 Proteins) is activated by ER stress cholesterol metabolism; they serve different functions

  7. Induction of STARD4 depended on both transcription factor ATF6 (show ATF6 Proteins) and an ERSE-like element in its promoter.

  8. StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis

Mouse (Murine) StAR-Related Lipid Transfer (START) Domain Containing 4 (STARD4) interaction partners

  1. a model of STARD4 membrane interaction and sterol binding and release that requires dynamic movement of both the Omega1 loop and membrane insertion of the C-terminal alpha-helix.

  2. StARD4's role can largely be compensated for by other intracellular cholesterol transporters.

  3. StarD4 is regulated by sterols via SREBP-2 (show SREBF2 Proteins), and StarD5 (show STARD5 Proteins) is activated by ER stress cholesterol metabolism; they serve different functions

  4. StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis

STARD4 Protein Profile

Protein Summary

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1\; MIM 184756) and by liver X receptors (e.g., LXRA\; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR\; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002

Gene names and symbols associated with STARD4

  • StAR-related lipid transfer (START) domain containing 4 (STARD4)
  • StAR-related lipid transfer (START) domain containing 4 (Stard4)
  • 4632419C16Rik protein
  • 9030213J02Rik protein
  • AA517649 protein
  • AW324468 protein

Protein level used designations for STARD4

START domain containing 4 sterol-regulated , START domain containing 4, sterol regulated , START domain-containing protein 4 , stAR-related lipid transfer protein 4

GENE ID SPECIES
134429 Homo sapiens
170459 Mus musculus
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