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STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). Additionally we are shipping STIM1 Antibodies (149) and STIM1 Proteins (18) and many more products for this protein.
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Human STIM1 ELISA Kit for Sandwich ELISA - ABIN824174
Wang, Sun, Huang, Wang, Hou, Sun, He, Krishna, Chiu, Lin, Yang, Chang: STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. in Oncogene 2014
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 ELISA Kits)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 ELISA Kits)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 ELISA Kits)+) entry
STIM1 plays role in PAR1 (show F2R ELISA Kits)-mediated Ca2 (show CA2 ELISA Kits)+ influx and Ca2 (show CA2 ELISA Kits)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1/TRPC1 (show TRPC1 ELISA Kits)-dependent store-operated Ca2 (show CA2 ELISA Kits)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 ELISA Kits)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (show ORAI1 ELISA Kits) are essential components of the signal transduction cascade that regulates sex pheromone production.
Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 ELISA Kits)+)sensor, stromal interaction molecule 1 (STIM1), to the Ca(2 (show CA2 ELISA Kits)+)-selective channel, Orai1 (show ORAI1 ELISA Kits), is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER
STIM11-469 and Orai1 (show ORAI1 ELISA Kits) W76A mutants do not reduce channel open probability.
T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB (show NFKB1 ELISA Kits)) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1 (show ORAI1 ELISA Kits)-mediated Calcium Entry.
study reports recessive STIM1 mutations in patients presenting with amelogenesis imperfecta and hypohidrosis without overt clinical immunodeficiency or myopathy
Data suggest that stromal interaction molecule 1 (STIM1) may be developed as a potential therapeutic target of cancer treatment.
We demonstrate that the Orai1 (show ORAI1 ELISA Kits)/STIM1 channel is regulated by changes of both intracellular and extracellular pH.
Sigma1 receptors attenuates STIM1 coupling to Orai1 (show ORAI1 ELISA Kits) and thereby inhibits SOCE.
Studies suggest that STIM1 protein and calcium channel Orai1 (show ORAI1 ELISA Kits)-mediated Ca2 (show CA2 ELISA Kits)+ signaling are the potential target for cancer therapy.
Studies indicate that Ca(2 (show CA2 ELISA Kits)+) sensor STIM1 and calcium channel Orai1 (show ORAI1 ELISA Kits) upregulation in cancer cells results in Ca2 (show CA2 ELISA Kits) + homeostasis remodeling and cell proliferation.
STIM1 also promoted cell migration and the epithelial-to-mesenchymal transition by activating TGF-beta (show TGFB1 ELISA Kits), Snail (show SNAI1 ELISA Kits) and Wnt (show WNT2 ELISA Kits)/beta-Catenin (show CTNNB1 ELISA Kits) pathways.
STIM1 and STIM2 (show Stim2 ELISA Kits) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 ELISA Kits).
We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 ELISA Kits)+) flux and a leaky SR compartment.
Stim1 silencing prevented mTOR complex 2 phosphorylation of Akt(S473) via a direct interaction between STIM1 and Rictor. This represses GSK-3beta activity and prevents/reverses cardiac hypertrophy.
role of STIM1, Orai1 (show TMEM132A ELISA Kits) and TRPCs, and thus SOCE, in thrombus formation, suggests that therapies directed against SOCE and targeting these molecules during cardiovascular and cerebrovascular events could improve traditional anti-thrombotic treatments
Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis
Results show the cytoplasmic domain of STIM1 as a target for calpains which cleave STIM1 to control its cellular abundance. Furthermore, STIM1's susceptibility to calpain cleavage leads to enhanced STIM1 degradation during the progression of apoptosis.
Orai1 (show TMEM132A ELISA Kits) and STIM1 have roles in inhibiting matrix protein expression
STIM1 plays opposing roles in vascular smooth muscle vs. endothelial cells in the regulation of vascular reactivity.
STIM1 is a multifunctional regulator of Ca(2 (show CA2 ELISA Kits)+) dynamics in SANCs that links SR Ca(2 (show CA2 ELISA Kits)+) store content with electrical events occurring in the plasma membrane, thereby contributing to automaticity of the SAN
STIM1L does not mediate rapid store-operated Ca(2 (show CA2 ELISA Kits)+) entry but can trap and gate Orai1 (show TMEM132A ELISA Kits) channels efficiently without remodeling cortical ER cisternae.
STIM1 is a key regulator of mGluR1 (show GRM1 ELISA Kits)-dependent Ca(2 (show CA2 ELISA Kits)+) signaling.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b