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STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). Additionally we are shipping STIM1 Proteins (19) and STIM1 Kits (2) and many more products for this protein.
Showing 10 out of 152 products:
Human Monoclonal STIM1 Primary Antibody for IF, WB - ABIN968271
Hu, Lee, Connors, Johnson, Burn, Su, Landes, Feinberg: A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. in Genomics 1998
Show all 5 references for ABIN968271
Human Polyclonal STIM1 Primary Antibody for EIA, IHC (p) - ABIN954978
Byun, Abhyankar, Lelarge, Plancoulaine, Palanduz, Telhan, Boisson, Picard, Dewell, Zhao, Jouanguy, Feske, Abel, Casanova: Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. in The Journal of experimental medicine 2010
Show all 4 references for ABIN954978
Human Polyclonal STIM1 Primary Antibody for EIA, IHC (p) - ABIN500827
Spassova, Soboloff, He, Xu, Dziadek, Gill: STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 4 references for ABIN500827
Human Monoclonal STIM1 Primary Antibody for ICC, IF - ABIN188961
Williams, Manji, Parker, Hancock, Van Stekelenburg, Eid, Senior, Kazenwadel, Shandala, Saint, Smith, Dziadek: Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. in The Biochemical journal 2001
Show all 3 references for ABIN188961
Cow (Bovine) Polyclonal STIM1 Primary Antibody for ICC, IF - ABIN258795
Meuchel, Stewart, Smelter, Abcejo, Thompson, Zaidi, Martin, Prakash: Neurokinin-neurotrophin interactions in airway smooth muscle. in American journal of physiology. Lung cellular and molecular physiology 2011
Show all 2 references for ABIN258795
Human Monoclonal STIM1 Primary Antibody for IF, WB - ABIN396503
Verma, Hoffmann, Kumar, Huang, Roe, Nguyen-Wu, Hashimoto, Hoffmann: Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. in Journal of immunology (Baltimore, Md. : 1950) 2011
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 Antibodies)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 Antibodies)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 Antibodies)+) entry
STIM1 plays role in PAR1 (show F2R Antibodies)-mediated Ca2 (show CA2 Antibodies)+ influx and Ca2 (show CA2 Antibodies)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca2 (show CA2 Antibodies)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 Antibodies)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (show ORAI1 Antibodies) are essential components of the signal transduction cascade that regulates sex pheromone production.
Mutations in the STIM1 and ORAI1 (show ORAI1 Antibodies) genes cause calcium dyshomeostasis in tubular aggregate myopathy. (Review)
STIM1 knockdown did not alter proliferation or apoptosis, but promoted cell adhesion and inhibited migration and invasion in the gastric cancer cells. STIM1 knockdown did not alter the expression or phosphorylation of mitogen-activated protein kinase (show MAPK1 Antibodies) (MEK (show MAP2K1 Antibodies)) or extracellular signal-regulated kinase (ERK (show EPHB2 Antibodies)), implying that STIM1 affected gastric cancer cell migration through a pathway independent of the MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) pathway.
SARAF (show TMEM66 Antibodies) overexpression attenuated store operated Ca2 (show CA2 Antibodies)+ entry and the STIM1-Orai1 (show ORAI1 Antibodies) interaction in cells endogenously expressing STIM1 and Orai1 (show ORAI1 Antibodies) while RNAi-mediated SARAF (show TMEM66 Antibodies) silencing induced opposite effects.
Calsequestrin-1 (show CASQ1 Antibodies) monomers suppress Store-Operated Ca2 (show CA2 Antibodies)+ Entry by interacting with STIM1 and attenuating STIM1 aggregation via its C-terminal amino acid 362-396.
the STIM1-Orai1 (show ORAI1 Antibodies) system has a role in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes
Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 Antibodies)+)sensor, stromal interaction molecule 1 (STIM1), to the Ca(2 (show CA2 Antibodies)+)-selective channel, Orai1 (show ORAI1 Antibodies), is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER
STIM11-469 and Orai1 (show ORAI1 Antibodies) W76A mutants do not reduce channel open probability.
T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB (show NFKB1 Antibodies)) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1 (show ORAI1 Antibodies)-mediated Calcium Entry.
study reports recessive STIM1 mutations in patients presenting with amelogenesis imperfecta and hypohidrosis without overt clinical immunodeficiency or myopathy
Data suggest that stromal interaction molecule 1 (STIM1) may be developed as a potential therapeutic target of cancer treatment.
STIM1 and STIM2 (show Stim2 Antibodies) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 Antibodies).
Data show that the STIM1 Ksp (Eg5 (show KIF11 Antibodies))-cre knockout mice produced more urine compared to control.
We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 Antibodies)+) flux and a leaky SR compartment.
Stim1 silencing prevented mTOR (show FRAP1 Antibodies) complex 2 phosphorylation of Akt (show AKT1 Antibodies)(S473) via a direct interaction between STIM1 and Rictor (show RICTOR Antibodies). This represses GSK-3beta (show GSK3b Antibodies) activity and prevents/reverses cardiac hypertrophy.
role of STIM1, Orai1 (show TMEM132A Antibodies) and TRPCs, and thus SOCE, in thrombus formation, suggests that therapies directed against SOCE and targeting these molecules during cardiovascular and cerebrovascular events could improve traditional anti-thrombotic treatments
Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis
Results show the cytoplasmic domain of STIM1 as a target for calpains which cleave STIM1 to control its cellular abundance. Furthermore, STIM1's susceptibility to calpain cleavage leads to enhanced STIM1 degradation during the progression of apoptosis.
Orai1 (show TMEM132A Antibodies) and STIM1 have roles in inhibiting matrix protein expression
STIM1 plays opposing roles in vascular smooth muscle vs. endothelial cells in the regulation of vascular reactivity.
STIM1 is a multifunctional regulator of Ca(2 (show CA2 Antibodies)+) dynamics in SANCs that links SR Ca(2 (show CA2 Antibodies)+) store content with electrical events occurring in the plasma membrane, thereby contributing to automaticity of the SAN
STIM1L does not mediate rapid store-operated Ca(2 (show CA2 Antibodies)+) entry but can trap and gate Orai1 (show TMEM132A Antibodies) channels efficiently without remodeling cortical ER cisternae.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b