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SUCNR1 encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. Additionally we are shipping Succinate Receptor 1 Antibodies (59) and Succinate Receptor 1 Kits (4) and many more products for this protein.
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We give an exhaustive overview of the known and hypothetical signaling partners of SUCNR1 in different in vitro and in vivo systems and also discuss the link between SUCNR1 intracellular pathways and its pathophysiological roles.
Through GPR91, succinate is involved in functions such as regulation of blood pressure, inhibition of lipolysis in white adipose tissue, development of retinal vascularization and cardiac hypertrophy. [review]
The findings indicate that succinate-GPR91 signaling may be involved in right ventricular hypertrophy via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling in vivo and in vitro.
results show that succinate plays an important role in HSC (show FUT1 Proteins) activation through GPR91 induction, and suggest that succinate and GPR91 may represent new therapeutic targets for modulating hepatic fibrosis
These results show for the first time that succinate plays an important role in cardiomyocyte hypertrophy through GPR91 activation and extend our understanding of how ischemia can induce hypertrophic cardiomyopathy
These findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry age-related macular degeneration.
results show that GPR91 when expressed in HEK293s cells couples exclusively through the Galphai pathway and acts through Galphai not only to inhibit cAMP production but also to increase intracellular Ca(2 (show CA2 Proteins)+)
A review of how neuron-derived factors, GPR91 and Semaphorin 3A (show SEMA3A Proteins), guide retinal vascularization and are major contributors to the pathogenesis of retinopathy of prematurity .
Succinate stimulates cell proliferation through GPR91 and requires activation of the Erk MAPK (show MAPK1 Proteins) pathway.
GPR91 is a receptor for succinate and mediates succin (show GPRC5D Proteins)ate-induced hypertension.
Sucnr1 knockout mice had increased energy expenditure, less white adipose tissue, and improved glucose buffering compared with controls. They became progressively hyperglycemic and failed to secrete insulin (show INS Proteins). Sucrn1 may be a sensor for dietary energy.
GPR91 is expressed in the retinal pigment epithelium with specific localization to the apical membrane, indicating that succinate in the subretinal space serves as the GPR91 agonist
SUCNR1 is located in the luminal membrane of macula densa cells of the juxtaglomerular apparatus in close proximity to renin (show REN Proteins)-producing granular cells, the cortical thick ascending limb, and cortical and inner medullary collecting duct cells.
GPR91, a previously orphan G-protein-coupled receptor (show GPRC5C Proteins), functions as a receptor for the citric acid cycle intermediate succinate
Release of the prohypertensive hormone renin (show REN Proteins) by the kidney, triggered by high levels of glucose, is mediated by a succinate / GPR91 paracrine signaling cascade in the glomerular endothelium.
Macul densa cells can sense alterations in local tissue metabolism via accumulation of tubular succinate and GPR91 signaling.
This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis.
probable G-protein coupled receptor 19
, G protein-coupled receptor 19
, probable G-protein coupled receptor 19-like
, succinate receptor 1
, G protein-coupled receptor 91
, G-protein coupled receptor 91
, P2Y purinoceptor 1
, G-protein-coupled receptor 91