You are viewing an incomplete version of our website. Please click to reload the website as full version.

Succinate Receptor 1 Proteins (SUCNR1)

SUCNR1 encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. Additionally we are shipping Succinate Receptor 1 Antibodies (38) and Succinate Receptor 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUCNR1 56670 Q9BXA5
SUCNR1 84112 Q99MT6
Rat SUCNR1 SUCNR1 408199 Q6IYF9
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top Succinate Receptor 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
$491.43
Details

SUCNR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Succinate Receptor 1 (SUCNR1) Interaction Partners

Human Succinate Receptor 1 (SUCNR1) interaction partners

  1. Through GPR91, succinate is involved in functions such as regulation of blood pressure, inhibition of lipolysis in white adipose tissue, development of retinal vascularization and cardiac hypertrophy. [review]

  2. The findings indicate that succinate-GPR91 signaling may be involved in right ventricular hypertrophy via PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling in vivo and in vitro.

  3. results show that succinate plays an important role in HSC (show FUT1 Proteins) activation through GPR91 induction, and suggest that succinate and GPR91 may represent new therapeutic targets for modulating hepatic fibrosis

  4. These results show for the first time that succinate plays an important role in cardiomyocyte hypertrophy through GPR91 activation and extend our understanding of how ischemia can induce hypertrophic cardiomyopathy

  5. These findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry age-related macular degeneration.

  6. results show that GPR91 when expressed in HEK293s cells couples exclusively through the Galphai pathway and acts through Galphai not only to inhibit cAMP production but also to increase intracellular Ca(2 (show CA2 Proteins)+)

  7. A review of how neuron-derived factors, GPR91 and Semaphorin 3A (show SEMA3A Proteins), guide retinal vascularization and are major contributors to the pathogenesis of retinopathy of prematurity .

  8. Succinate stimulates cell proliferation through GPR91 and requires activation of the Erk MAPK (show MAPK1 Proteins) pathway.

  9. GPR91 is a receptor for succinate and mediates succin (show GPRC5D Proteins)ate-induced hypertension.

Mouse (Murine) Succinate Receptor 1 (SUCNR1) interaction partners

  1. Sucnr1 knockout mice had increased energy expenditure, less white adipose tissue, and improved glucose buffering compared with controls. They became progressively hyperglycemic and failed to secrete insulin (show INS Proteins). Sucrn1 may be a sensor for dietary energy.

  2. These findings suggest that deficiency in SUCNR1 is a possible contributing factor to the pathogenesis of dry age-related macular degeneration.

  3. GPR91 is expressed in the retinal pigment epithelium with specific localization to the apical membrane, indicating that succinate in the subretinal space serves as the GPR91 agonist

  4. SUCNR1 is located in the luminal membrane of macula densa cells of the juxtaglomerular apparatus in close proximity to renin (show REN Proteins)-producing granular cells, the cortical thick ascending limb, and cortical and inner medullary collecting duct cells.

  5. GPR91, a previously orphan G-protein-coupled receptor (show GPRC5C Proteins), functions as a receptor for the citric acid cycle intermediate succinate

  6. Release of the prohypertensive hormone renin (show REN Proteins) by the kidney, triggered by high levels of glucose, is mediated by a succinate / GPR91 paracrine signaling cascade in the glomerular endothelium.

  7. Macul densa cells can sense alterations in local tissue metabolism via accumulation of tubular succinate and GPR91 signaling.

Succinate Receptor 1 (SUCNR1) Protein Profile

Protein Summary

This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis.

Gene names and symbols associated with Succinate Receptor 1 Proteins (SUCNR1)

  • G protein-coupled receptor 19 (gpr19)
  • G protein-coupled receptor 19 (GPR19)
  • succinate receptor 1 (SUCNR1)
  • succinate receptor 1 (Sucnr1)
  • GPR19 protein
  • Gpr91 protein
  • zgc:63912 protein

Protein level used designations for Succinate Receptor 1 Proteins (SUCNR1)

probable G-protein coupled receptor 19 , G protein-coupled receptor 19 , probable G-protein coupled receptor 19-like , succinate receptor 1 , G protein-coupled receptor 91 , G-protein coupled receptor 91 , P2Y purinoceptor 1 , G-protein-coupled receptor 91

GENE ID SPECIES
393969 Danio rerio
540647 Bos taurus
548962 Xenopus (Silurana) tropicalis
697072 Macaca mulatta
740660 Pan troglodytes
100066597 Equus caballus
100387863 Callithrix jacchus
100449547 Pongo abelii
100625907 Sus scrofa
485719 Canis lupus familiaris
738824 Pan troglodytes
771768 Gallus gallus
56670 Homo sapiens
84112 Mus musculus
408199 Rattus norvegicus
Selected quality suppliers for Succinate Receptor 1 Proteins (SUCNR1)
Did you look for something else?