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SUCNR1 Products

(Succinate Receptor 1 (SUCNR1))
This gene encodes a G-protein-coupled receptor for succinate, an intermediate molecule of the citric acid cycle. It is involved in the promotion of hematopoietic progenitor cell development, and it has a potential role in renovascular hypertension which has known correlations to renal failure, diabetes and atherosclerosis. [provided by RefSeq, Oct 2009].

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Featured SUCNR1 Categories

SUCNR1 Antibodies

High quality antibodies with extensive validation data.

SUCNR1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SUCNR1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SUCNR1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IF, IHC
Validations
  • (4)
Cat. No. ABIN7170906
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB, IF, ICC
Validations
  • (2)
Cat. No. ABIN6265363
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN1048897
Quantity 50 μg
Datasheet Datasheet

Recommended SUCNR1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1159995
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1159996
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1159997
Quantity 96 tests
Datasheet Datasheet

Recommended SUCNR1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN1330532
Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3106209
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3128076
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SUCNR1 products

Wu, Huang, Hsieh, Wang, Yen, Lee, Yeh, Peng, Kuo, Wen, Lin, Hsiao, Wu, Kung, Hsu, Kuo: "Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor." in: Molecular cell, Vol. 77, Issue 2, pp. 213-227.e5, (2020) (PubMed).

Caielli, Veiga, Balasubramanian, Athale, Domic, Murat, Banchereau, Xu, Chandra, Chung, Walters, Baisch, Wright, Punaro, Nassi, Stewart, Fuller, Ucar, Ueno, Zhou, Banchereau, Pascual: "A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate." in: Nature medicine, Vol. 25, Issue 1, pp. 75-81, (2019) (PubMed).

Wang, Xu, Yuan, Xu, Zhang, Li, Wang, Yin, Zhang, Cai, Zhu, Xu, Liang, Schaul, Xie, Yue, Liao, Yu, Luo, Zhou, Yang, He, Du, Zhou, Deng, Wang, Gao, Zhu, Xi, Zhang, Shu, Jiang: "Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling." in: EMBO reports, Vol. 20, Issue 9, pp. e47892, (2019) (PubMed).

Nguyen, Park, Le, Park, Choi, Cho: "Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition." in: Biochemical and biophysical research communications, Vol. 495, Issue 4, pp. 2649-2656, (2018) (PubMed).

Peruzzotti-Jametti, Bernstock, Vicario, Costa, Kwok, Leonardi, Booty, Bicci, Balzarotti, Volpe, Mallucci, Manferrari, Donegà, Iraci, Braga, Hallenbeck, Murphy, Edenhofer, Frezza, Pluchino: "Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation." in: Cell stem cell, Vol. 22, Issue 3, pp. 355-368.e13, (2018) (PubMed).

Mu, Zhao, Xu, Shi, Geng, Shen, Zhang, Pan, Yang, Hu, Lv, Wen, You: "Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation." in: Oncotarget, Vol. 8, Issue 8, pp. 13174-13185, (2017) (PubMed).

Guo, Xie, Li, Yang, Yu, Zhang, Zhang, Saxena, Snyder, Wu, Li: "Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis." in: Nature communications, Vol. 8, pp. 15621, (2017) (PubMed).

McCreath, Espada, Gálvez, Benito, de Molina, Sepúlveda, Cervera: "Targeted disruption of the SUCNR1 metabolic receptor leads to dichotomous effects on obesity." in: Diabetes, Vol. 64, Issue 4, pp. 1154-67, (2015) (PubMed).

Hu, Li, Du, Chen, Wang, Xiong, Wu: "The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells." in: International journal of molecular medicine, Vol. 36, Issue 1, pp. 130-8, (2015) (PubMed).

Li, Hu, Du, Chen, Wang, Wu: "ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes." in: Molecular vision, Vol. 20, pp. 1109-21, (2014) (PubMed).

Synonyms and alternative names related to SUCNR1

succinate receptor 1 (SUCNR1), succinate receptor 1 (Sucnr1), GPR91, Gpr91

Protein level used designations for SUCNR1

  • G protein-coupled receptor 91
  • G-protein coupled receptor 91
  • P2Y purinoceptor 1
  • succinate receptor 1
  • G-protein-coupled receptor 91
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