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Sulfatase Modifying Factor 1 Proteins (SUMF1)

SUMF1 encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Additionally we are shipping SUMF1 Antibodies (56) and SUMF1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUMF1 285362 Q8NBK3
SUMF1 58911 Q8R0F3
Rat SUMF1 SUMF1 362409  
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Top SUMF1 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$413.21
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$385.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$810.39
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$345.35
Details

SUMF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Top referenced SUMF1 Proteins

  1. Human SUMF1 Protein expressed in Escherichia coli (E. coli) - ABIN667612 : Cosma, Pepe, Annunziata, Newbold, Grompe, Parenti, Ballabio: The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. in Cell 2003 (PubMed)
    Show all 2 references for ABIN667612

More Proteins for Sulfatase Modifying Factor 1 (SUMF1) Interaction Partners

Human Sulfatase Modifying Factor 1 (SUMF1) interaction partners

  1. SUMF1 catalyses a monooxygenase type of reaction.

  2. This detailed clinical description and follow-up of a cohort of patients, together with the molecular characterisation of their underlying defects, contribute to improved knowledge of multiple sulfatase deficiency.

  3. MSD (show MESDC2 Proteins) presenting in the newborn period with hypotonia, apnoea, cyanosis and rolling eyes, hepato-splenomegaly and deafness. This patient was compound heterozygous for two so far undescribed SUMF1 mutations (c.191C > A; p.S64X and c.818A > G; p.D273G

  4. The complete kinetic parameters for both forms of FGE are described, along with a proposed mechanism for FGE catalysis that accounts for the copper-dependent activity.

  5. A novel missense mutation & an insertional truncating mutation in SUMF1 gene causing nultiple sulphatase deficiency.

  6. furin (show FURIN Proteins)-mediated processing of FGE during secretion is a physiological means of higher eukaryotic cells to regulate FGE activity upon exit from the endoplasmic reticulum

  7. Phenotypic outcome in Multiple Sulfatase Deficiency depends on both residual FGE activity as well as protein stability.

  8. This study identified genetic variation of SUMF1 in genes associated with in vivo glutamate (show GRIN1 Proteins) measured using 1H magnetic resonance spectroscopic imaging in the grey matter of patients with multiple sclerosis.

  9. mutational analysis of SUMF1 in 20 Multiple sulfatase deficiency patients of different ethnic origin

  10. characterization of the human Calpha (show PRKACA Proteins)-formylglycine-generating enzyme

Mouse (Murine) Sulfatase Modifying Factor 1 (SUMF1) interaction partners

  1. Sumf1(-/-) astrocytes failed to support the survival and function of wild-type cortical neurons, suggesting a non-cell autonomous mechanism for neurodegeneration.

  2. Sumf1 controls hematopoietic stem progenitor cell differentiation and hematopoietic lineage development through FGF and Wnt (show WNT2 Proteins) signaling.

  3. Sumf1 is indispensable for sulfatase activation in mice and mammals, differently from bacteria, have a single sulfatase modification system

SUMF1 Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with SUMF1

  • sulfatase modifying factor 1 (SUMF1)
  • sulfatase modifying factor 1 (Sumf1)
  • AA543204 protein
  • AAPA3037 protein
  • AI463102 protein
  • AI851573 protein
  • FGE protein

Protein level used designations for SUMF1

C-alpha-formylglycine-generating enzyme 1 , FGly-generating enzyme , sulfatase-modifying factor 1 , sulfatase-modifying factor

GENE ID SPECIES
285362 Homo sapiens
58911 Mus musculus
362409 Rattus norvegicus
536435 Bos taurus
484681 Canis lupus familiaris
100514188 Sus scrofa
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