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Suppressor of Var1, 3-Like 1 (S. Cerevisiae) Proteins (SUPV3L1)

Major helicase player in mitochondrial RNA metabolism. Additionally we are shipping Suppressor of Var1, 3-Like 1 (S. Cerevisiae) Antibodies (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUPV3L1 6832 Q8IYB8
SUPV3L1 338359 Q80YD1
SUPV3L1 294385 Q5EBA1
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Top Suppressor of Var1, 3-Like 1 (S. Cerevisiae) Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,150.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
Details

SUPV3L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Suppressor of Var1, 3-Like 1 (S. Cerevisiae) (SUPV3L1) Interaction Partners

Human Suppressor of Var1, 3-Like 1 (S. Cerevisiae) (SUPV3L1) interaction partners

  1. SUV3 bridges PNPase (show PNPT1 Proteins) and mtPAP (show MTPAP Proteins) to form a transient complex in modulating mt-mRNA poly(A) tail length depending on the mitochondrial matrix Pi level.

  2. Interaction between PNPase (show PNPT1 Proteins) and hSuv3 is essential for efficient mitochondrial RNA degradation.

  3. Localisation of hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA.

  4. Human SUV3 is an ATP-dependent multiple-substrate helicase; in addition to dsRNA and dsDNA unwinding activity, SUV3-70 and SUV3-83 can unwind heteroduplexes of RNA and DNA.

  5. Suv3 protein interacts with HBXIP (show HBXIP Proteins), previously identified as a cofactor of survivin (show BIRC5 Proteins) in suppression of apoptosis

  6. Down-regulation of hSUV3 results in cell cycle perturbations and in apoptosis, which is both AIF (show AIFM1 Proteins)- and caspase (show CASP3 Proteins)-dependent, and proceeds with the induction of p53 (show TP53 Proteins).

  7. Human SUV3 protein interacts with human WRN and BLM helicases. Silencing of the SUV3 gene in the human cell line HeLa resulted in elevation of homologous recombination as measured by the frequency of sister chromatid exchange during mitotic cell division.

  8. SUV3 is essential for maintaining proper mitochondrial function, likely through a conserved role in mitochondrial RNA regulation.

Mouse (Murine) Suppressor of Var1, 3-Like 1 (S. Cerevisiae) (SUPV3L1) interaction partners

  1. Spatial and temporal aspects of Supv3L1 promoter activity.

  2. Mice homozygous for Supv3L1 mutation die in utero before midgestation.

  3. Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes.

Suppressor of Var1, 3-Like 1 (S. Cerevisiae) (SUPV3L1) Protein Profile

Protein Summary

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria\; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).

Gene names and symbols associated with SUPV3L1

  • suppressor of var1, 3-like 1 (S. cerevisiae) (SUPV3L1)
  • suppressor of var1, 3-like 1 (S. cerevisiae) (Supv3l1)
  • suppressor of var1, 3-like 1 (S. cerevisiae) (supv3l1)
  • 6330443E10Rik protein
  • SUV3 protein
  • wu:fc19b02 protein
  • wu:fe37e06 protein

Protein level used designations for SUPV3L1

ATP-dependent RNA helicase SUPV3L1, mitochondrial , SUV3-like protein 1 , suppressor of var1 3-like protein 1 , suppressor of var1, 3-like 1(SUV3)

GENE ID SPECIES
6832 Homo sapiens
505988 Bos taurus
338359 Mus musculus
294385 Rattus norvegicus
423697 Gallus gallus
570852 Danio rerio
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