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Major helicase player in mitochondrial RNA metabolism. Additionally we are shipping Suppressor of Var1, 3-Like 1 (S. Cerevisiae) Antibodies (13) and many more products for this protein.
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SUV3 bridges PNPase (show PNPT1 Proteins) and mtPAP (show MTPAP Proteins) to form a transient complex in modulating mt-mRNA poly(A) tail length depending on the mitochondrial matrix Pi level.
Interaction between PNPase (show PNPT1 Proteins) and hSuv3 is essential for efficient mitochondrial RNA degradation.
Localisation of hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA.
Human SUV3 is an ATP-dependent multiple-substrate helicase; in addition to dsRNA and dsDNA unwinding activity, SUV3-70 and SUV3-83 can unwind heteroduplexes of RNA and DNA.
Suv3 protein interacts with HBXIP (show HBXIP Proteins), previously identified as a cofactor of survivin (show BIRC5 Proteins) in suppression of apoptosis
Down-regulation of hSUV3 results in cell cycle perturbations and in apoptosis, which is both AIF (show AIFM1 Proteins)- and caspase (show CASP3 Proteins)-dependent, and proceeds with the induction of p53 (show TP53 Proteins).
Human SUV3 protein interacts with human WRN and BLM helicases. Silencing of the SUV3 gene in the human cell line HeLa resulted in elevation of homologous recombination as measured by the frequency of sister chromatid exchange during mitotic cell division.
SUV3 is essential for maintaining proper mitochondrial function, likely through a conserved role in mitochondrial RNA regulation.
Spatial and temporal aspects of Supv3L1 promoter activity.
Mice homozygous for Supv3L1 mutation die in utero before midgestation.
Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes.
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria\; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).
ATP-dependent RNA helicase SUPV3L1, mitochondrial
, SUV3-like protein 1
, suppressor of var1 3-like protein 1
, suppressor of var1, 3-like 1(SUV3)