SUPV3L1 Products
(Suppressor of Var1, 3-Like 1 (SUPV3L1))
Categories
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria\; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).
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Featured SUPV3L1 Categories
SUPV3L1 Antibodies
High quality antibodies with extensive validation data.
SUPV3L1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SUPV3L1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, FACS, IHC (p)
Validations
- (5)
- (4)
Cat. No.
ABIN1881857
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (5)
Cat. No.
ABIN520625
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7145007
Quantity
100 μL
Datasheet
Datasheet
Recommended SUPV3L1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6233067
Quantity
96 tests
Datasheet
Datasheet
Recommended SUPV3L1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1321919
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3095682
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3136077
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SUPV3L1 products
: "Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance." in: Nucleic acids research, Vol. 38, Issue 1, pp. 279-98, (2010) (PubMed).: "Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality." in: The Journal of biological chemistry, Vol. 284, Issue 31, pp. 20812-21, (2009) (PubMed).
: "Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 27064-73, (2008) (PubMed).
: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, (2008) (PubMed).
: "Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality." in: Mechanisms of ageing and development, Vol. 128, Issue 11-12, pp. 609-17, (2007) (PubMed).
Synonyms and alternative names related to SUPV3L1
Suv3 like RNA helicase (SUPV3L1), suppressor of var1, 3-like 1 (S. cerevisiae) (Supv3l1), Suv3 like RNA helicase (Supv3l1), SUV3-like helicase (supv3l1), 6330443E10Rik, SUV3, wu:fc19b02, wu:fe37e06Protein level used designations for SUPV3L1
- ATP-dependent RNA helicase SUPV3L1, mitochondrial
- SUV3-like protein 1
- suppressor of var1 3-like protein 1
- suppressor of var1, 3-like 1(SUV3)
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