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SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. Additionally we are shipping Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteins (8) and many more products for this protein.
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Human Polyclonal SUV39H1 Primary Antibody for WB - ABIN387991
Fujita, Watanabe, Ichimura, Tsuruzoe, Shinkai, Tachibana, Chiba, Nakao: Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. in The Journal of biological chemistry 2003
Show all 6 references for ABIN387991
Human Polyclonal SUV39H1 Primary Antibody for EIA, IHC (p) - ABIN356686
Schotta, Ebert, Krauss, Fischer, Hoffmann, Rea, Jenuwein, Dorn, Reuter: Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. in The EMBO journal 2002
Show all 5 references for ABIN356686
Human Monoclonal SUV39H1 Primary Antibody for WB - ABIN387778
Chen, Li, Zwolinska, Smith, Cross, Koomen, Yuan, Jenuwein, Marine, Wright, Chen: MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. in The EMBO journal 2010
Show all 5 references for ABIN387778
Human Polyclonal SUV39H1 Primary Antibody for WB - ABIN657943
Goyama, Nitta, Yoshino, Kako, Watanabe-Okochi, Shimabe, Imai, Takahashi, Kurokawa: EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization. in Leukemia 2010
Show all 5 references for ABIN657943
Human Monoclonal SUV39H1 Primary Antibody for ChIP, IP - ABIN2668694
Terada: Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition. in Molecular biology of the cell 2006
Show all 3 references for ABIN2668694
Cow (Bovine) Polyclonal SUV39H1 Primary Antibody for WB - ABIN2779665
Kang, Lee, Kim, Chang, Kyu Park, Chun, Song, Park, Kim: Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer. in International journal of cancer. Journal international du cancer 2007
Cow (Bovine) Polyclonal SUV39H1 Primary Antibody for IHC, WB - ABIN2779664
Frontelo, Leader, Yoo, Potocki, Crawford, Kulik, Lechleider: Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression. in Oncogene 2004
we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1
These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.
CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (show DEFA1 Antibodies)/DNMT3A (show DNMT3A Antibodies) in DNA methylation (show HELLS Antibodies)-based epigenetic silencing
PHF2 (show PHF1 Antibodies) is likely to repress rDNA transcription by competing with PHF8 (show PHF8 Antibodies) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
High SUV39H1 expression is associated with hepatocellular carcinoma.
Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2 (show BCL2 Antibodies), pro-caspase-9 (show CASP9 Antibodies), pro-caspase-3 (show CASP3 Antibodies) and C-myc (show MYC Antibodies). Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy.
SUV39H1 expression was upregulated in glioma cell lines and in glioma tissues compared to normal brain, being positively correlated with grade and histological malignancy.
Short-chain fatty acids from periodontal pathogens suppress EZH2 (show EZH2 Antibodies), and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication.
Results suggest that by regulating JMJD2b (show KDM4B Antibodies) and SUV39H1 expression, p53 (show TP53 Antibodies) not only controls transcription but also promotes HC relaxation to accelerate a rate-limiting step in the repair of complex genomes.
The SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically.
Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (show CBX5 Antibodies) to the promoter of the ancestral Oct4 (show POU5F1 Antibodies) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.
Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.
Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
These findings indicate that Suv39h1 enhances AP-2alpha (show TFAP2A Antibodies)-mediated transcriptional repression of C/EBPalpha (show CEBPA Antibodies) in an epigenetic manner and further inhibits adipocyte differentiation.
A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.
Data indicate that loss of suv39h1 prevents Myc (show MYC Antibodies)-induced chromosomal instability.
Smads recruit H3K9 methyltransferases Suv39h1 to the IL-2 (show IL2 Antibodies) promoter, thereby inducing suppressive histone methylation and inhibiting T cell receptor-mediated IL-2 (show IL2 Antibodies) transcription.
SirT1 (show SIRT1 Antibodies) preserves heterochromatin structure: it modulates Suv39h1 protein levels in stress conditions by preventing MDM2 (show MDM2 Antibodies)-mediated polyubiquitination at K87.
novel role for microRNA in the epigenetic regulation of inflammatory genes in vascular smooth muscle cells of diabetic mice through downregulation of SUV39h1.
Ring1B (show RNF2 Antibodies) and Suv39h1 have mutually exclusive roles in regulating distinct chromatin states at key developmental genes, and play a part in how lineage specification can be reinforced during early development
The identification of a histone H3 (show HIST3H3 Antibodies) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.
These results suggest that Dnmt1 (show DNMT1 Antibodies) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (show DNMT1 Antibodies) and Suv39h1 help guide the terminal differentiation of particular tissues.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
histone-lysine N-methyltransferase SUV39H1
, su(var)3-9 homolog 1
, Su(var)3-9 homolog 1
, histone H3-K9 methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 1
, lysine N-methyltransferase 1A
, position-effect variegation 3-9 homolog
, H3-K9-HMTase 1
, Suv39h histone methyltransferase
, histone-lysine N-methyltransferase SUV39H1-A
, su(var)3-9 homolog 1-A
, suppressor of variegation 3-9 homolog 1
, suppressor of variegation 3-9 homolog 1-A
, suppressor of variegation 3-9-like 1a