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May play a role in vesicle trafficking (By similarity). Additionally we are shipping Synaptotagmin Like Protein 1 Proteins (2) and many more products for this protein.
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Human Polyclonal SYTL1 Primary Antibody for EIA, WB - ABIN955048
Neumüller, Hoffmeister, Babica, Prelle, Gegenbauer, Smolenski: Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets. in Blood 2009
Show all 5 references for ABIN955048
High Expression of secretory leukocyte protease inhibitor (show SLPI Antibodies) is associated with metastasis in colorectal cancer.
SLPI (show SLPI Antibodies) regulation and activity is altered in the nasal mucosa of smokers.
Cdk2 (show CDK2 Antibodies) also binds the N-terminal domain of Fbw7 (show FBXW7 Antibodies)-gamma as well as SLP-1.
during exocytosis, actin depolymerization commences near the secretory organelle, not the plasma membrane, and secretory granules use a JFC1- and GMIP-dependent molecular mechanism to traverse cortical actin.
transcriptional activation of JFC1 by the TNFalpha (show TNF Antibodies)/NF-kappaB (show NFKB1 Antibodies) pathway is significant in prostate carcinoma cell lines
evidence that JFC1 differentially regulates the secretion of PSAP (show PSAP Antibodies) and PSA (show PLAG1 Antibodies), and that Rab27a (show RAB27A Antibodies) and PI3K (show PIK3CA Antibodies) play a central role in the exocytosis of prostate-specific (show KLK3 Antibodies) markers
Levels of mRNA and immunostaining of the antiproteases elafin (show PI3 Antibodies) and SLPI (show SLPI Antibodies) were enhanced strongly in inflamed versus noninflamed UC. Elafin (show PI3 Antibodies) and SLPI (show SLPI Antibodies) may be added to the list of defensin (show DEF Antibodies)-like peptides with diminished induction in CD versus UC.
These results suggest that both Slp1 and Slp2-a (show SYTL2 Antibodies) may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
Slp1 inhibits dense granule secretion in platelets and that Rap1GAP2 modulates secretion by binding to Slp1.
Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp (show SEPT9 Antibodies) homology domain (SHD (show SHD Antibodies)) (PMID: 11327731). The SHD (show SHD Antibodies) of Slp1/Jfc1 specifically and directly binds the GTP (show AK3 Antibodies)-bound form of Rab27A (show RAB27A Antibodies) (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
Granuphilin (show SYTL4 Antibodies) and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
Expression of Rab27B (show RAB27B Antibodies)-binding proteinm Sytl1 (show SYT1 Antibodies) in pancreatic acinar cells and its involvement in amylase (show AMY Antibodies) secretion are reported.
May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).
NADPH oxidase-related, C2 domain-containing protein
, synaptotagmin-like protein 1