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anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Antibodies

SYVN1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. Additionally we are shipping Synovial Apoptosis Inhibitor 1, Synoviolin Proteins (7) and Synovial Apoptosis Inhibitor 1, Synoviolin Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SYVN1 84447 Q86TM6
SYVN1 74126 Q9DBY1
SYVN1 361712  
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Top anti-Synovial Apoptosis Inhibitor 1, Synoviolin Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of hHRD1-A601 (ABIN388980) in T47D cell line lysates (35 µg/lane). HRD1 (arrow) was detected using the purified polyclonal antibody. The anti-HRD1 Pab (ABIN388980) is used in Western blot to detect HRD1 in mouse kidney tissue lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (fro), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse kidney labeled with Rabbit Anti SYVN1/HRD1 Polyclonal Antibody, Unconjugated (ABIN671811) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse liver labeled with Rabbit Anti SYVN1/HRD1 Polyclonal Antibody, Unconjugated (ABIN671811) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-HRD1 Pab (ABIN1882139) in mouse brain tissue lysate (35 µg/lane). HRD1(arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of HRD1 Antibody (N-term) (ABIN650702) in SK-BR-3 cell line lysates (35 µg/lane). HRD1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p) Anti-SYVN1 / HRD1 antibody  ABIN1049376 IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with SYVN1followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with SYVN1followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details

SYVN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Synovial Apoptosis Inhibitor 1, Synoviolin Antibodies

  1. Human Polyclonal SYVN1 Primary Antibody for IF, IHC (p) - ABIN388980 : Kaneko, Koike, Saito, Kitamura, Okuma, Nomura: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 (PubMed)
    Show all 11 references for ABIN388980

  2. Human Polyclonal SYVN1 Primary Antibody for WB - ABIN1882139 : Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. in The Journal of biological chemistry 2004 (PubMed)
    Show all 6 references for ABIN1882139

  3. Human Polyclonal SYVN1 Primary Antibody for WB - ABIN650702 : Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. in Journal of immunology (Baltimore, Md. : 1950) 2013 (PubMed)
    Show all 3 references for ABIN650702

  4. Human Polyclonal SYVN1 Primary Antibody for IHC (fro), IF (p) - ABIN671811 : Yan, Zheng, Chen, Liu, Li, Hu, Pei, Li: Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats. in Experimental diabetes research 2011 (PubMed)
    Show all 2 references for ABIN671811

  5. Human Polyclonal SYVN1 Primary Antibody for WB - ABIN2774801 : Cattaneo, Otsu, Fagioli, Martino, Lotti, Sitia, Biunno: SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. in Journal of cellular physiology 2008 (PubMed)

  6. Human Polyclonal SYVN1 Primary Antibody for EIA, IHC (p) - ABIN357625 : Yamada, Ishihara, Tamura, Takahashi, Yamaguchi, Takei, Tokita, Satake, Tashiro, Katagiri, Aburatani, Miyazaki, Oka: WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. in Human molecular genetics 2006 (PubMed)

More Antibodies against Synovial Apoptosis Inhibitor 1, Synoviolin Interaction Partners

Human Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) interaction partners

  1. These findings uncover a novel role for HRD1 in breast cancer.

  2. The inherently unstable nature of the human SEL1L (show SEL1L Antibodies) protein lies in its transmembrane domain, and that association of HRD1 with the SEL1L (show SEL1L Antibodies) transmembrane domain restored its stability.

  3. specific silencing of Derlin-2 (show DERL2 Antibodies), p97 (show EIF4G2 Antibodies) and HRD1 by shRNAs increases steady state levels of proinsulin (show INS Antibodies). these ERAD constituents are critically involved in proinsulin (show INS Antibodies) degradation and may therefore also play a role in subsequent antigen generation.

  4. Charcot-Marie-Tooth disease-related PMP22 (show PMP22 Antibodies) is trapped in the endoplasmic reticulum by calnexin (show CANX Antibodies)-dependent retention and Rer1 (show RER1 Antibodies)-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system.

  5. Results show that HRD1 and RFP2 (show TRIM13 Antibodies) contributes are required for the disposal of V247M alpha-sarcoglycan (show SGCA Antibodies) mutant.

  6. Herp localizes to the endoplasmic reticulum-derived quality control compartment (ERQC) and recruits HRD1, which targets to endoplasmic reticulum associated degradation the substrate presented by the OS-9 lectin at the ERQC.

  7. HRD1 and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5 (show ABCG5 Antibodies)/ABCG8 (show ABCG8 Antibodies).

  8. identified Hrd1 as a novel E3 ubiquitin ligase (show MUL1 Antibodies) responsible for compromised Nrf2 (show GABPA Antibodies) response during liver cirrhosis

  9. a new HRD1-associated membrane protein named HERP2 (show HEY1 Antibodies), which is homologous to the previously identified HRD1 partner HERP1 (show HEY2 Antibodies). Despite sequence homology, HERP2 (show HEY1 Antibodies) is constitutively expressed in cells, whereas HERP1 (show HEY2 Antibodies) is highly induced by ER stress.

  10. the interactions between P97 and these motifs, including VCP-binding motif (VBM) and VCP-interacting motif (VIM). The solution structures of the VBM motif from HRD1 and the VIM motif from SVIP are both comprised mainly of a single alpha-helix.

Mouse (Murine) Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) interaction partners

  1. SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.

  2. Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.

  3. Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.

  4. The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC Antibodies)-1b.

  5. Data indicate that E3 ubiquitin-protein ligase (show UBE2K Antibodies) Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1 (show PRDM1 Antibodies)) to promote MHC-II antigen expression.

  6. oxidative stress-induced (show SQSTM1 Antibodies) HRD1 insolubilization might be involved in a vicious cycle of increased amyloid beta production and amyloid beta-induced oxidative stress in Alzheimer's disease pathogenesis.

  7. results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A Antibodies) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis

  8. Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1 (show RER1 Antibodies), for degradation.

  9. HRD1 is colocated with the neural stem cell marker protein nestin (show NES Antibodies) and glial fibrillary acidic protein (show GFAP Antibodies) in the endoplasmic reticulum membrane of the NSCs of the subventricular zone (SVZ astrocytes) but in the cell nucleus of in the dentate gyrus

  10. these results clearly suggest that both beta-TrCP (show BTRC Antibodies)- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Antibodies) to maintain cellular homeostasis.

Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) Antigen Profile

Protein Summary

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.

Gene names and symbols associated with SYVN1

  • synovial apoptosis inhibitor 1, synoviolin (syvn1) antibody
  • synovial apoptosis inhibitor 1, synoviolin (SYVN1) antibody
  • synovial apoptosis inhibitor 1, synoviolin (Syvn1) antibody
  • 1200010C09Rik antibody
  • AW211966 antibody
  • C85322 antibody
  • D530017H19Rik antibody
  • DER3 antibody
  • Hrd1 antibody
  • RGD1310488 antibody

Protein level used designations for SYVN1

E3 ubiquitin-protein ligase synoviolin , synovial apoptosis inhibitor 1, synoviolin , HMG-coA reductase degradation 1 homolog , synoviolin 1 , HRD1 protein

GENE ID SPECIES
100327246 Xenopus (Silurana) tropicalis
100514334 Sus scrofa
100581754 Nomascus leucogenys
84447 Homo sapiens
483746 Canis lupus familiaris
508358 Bos taurus
74126 Mus musculus
361712 Rattus norvegicus
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