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SYVN1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. Additionally we are shipping Synovial Apoptosis Inhibitor 1, Synoviolin Proteins (7) and Synovial Apoptosis Inhibitor 1, Synoviolin Kits (3) and many more products for this protein.
Showing 10 out of 101 products:
Human Polyclonal SYVN1 Primary Antibody for IF, IHC (p) - ABIN388980
Kaneko, Koike, Saito, Kitamura, Okuma, Nomura: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 11 references for ABIN388980
Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN250959
Soundararajan, Wang, Melters, Pearce: Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. in The Journal of biological chemistry 2010
Show all 7 references for ABIN250959
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN1882139
Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. in The Journal of biological chemistry 2004
Show all 6 references for ABIN1882139
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN650702
Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. in Journal of immunology (Baltimore, Md. : 1950) 2013
Show all 3 references for ABIN650702
Human Polyclonal SYVN1 Primary Antibody for IHC (fro), IF (p) - ABIN671811
Yan, Zheng, Chen, Liu, Li, Hu, Pei, Li: Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats. in Experimental diabetes research 2011
Show all 2 references for ABIN671811
Human Polyclonal SYVN1 Primary Antibody for ELISA, IHC - ABIN4319849
Kaneko: [Possible involvement of HRD1 (ubiquitin E3 ligase) in neurodegenerative diseases]. in Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2009
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN2774801
Cattaneo, Otsu, Fagioli, Martino, Lotti, Sitia, Biunno: SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. in Journal of cellular physiology 2008
Human Polyclonal SYVN1 Primary Antibody for EIA, IHC (p) - ABIN357625
Yamada, Ishihara, Tamura, Takahashi, Yamaguchi, Takei, Tokita, Satake, Tashiro, Katagiri, Aburatani, Miyazaki, Oka: WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. in Human molecular genetics 2006
Prion protein (show PRNP Antibodies) mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP (show GDF10 Antibodies).
OS-9 (show OS9 Antibodies), an ER-resident lectin, acts downstream of Grp94 (show HSP90B1 Antibodies) to further recognize misfolded alpha1 subunits in a glycan-dependent manner. This delivers misfolded alpha1 subunits to the Hrd1-mediated ubiquitination and the valosin-containing protein (show vcp Antibodies)-mediated extraction pathway.
These findings uncover a novel role for HRD1 in breast cancer.
The inherently unstable nature of the human SEL1L (show SEL1L Antibodies) protein lies in its transmembrane domain, and that association of HRD1 with the SEL1L (show SEL1L Antibodies) transmembrane domain restored its stability.
specific silencing of Derlin-2 (show DERL2 Antibodies), p97 (show EIF4G2 Antibodies) and HRD1 by shRNAs increases steady state levels of proinsulin (show INS Antibodies). these ERAD constituents are critically involved in proinsulin (show INS Antibodies) degradation and may therefore also play a role in subsequent antigen generation.
Charcot-Marie-Tooth disease-related PMP22 (show PMP22 Antibodies) is trapped in the endoplasmic reticulum by calnexin (show CANX Antibodies)-dependent retention and Rer1 (show RER1 Antibodies)-mediated early Golgi retrieval systems and partly degraded by the Hrd1-mediated endoplasmic reticulum-associated degradation system.
Results show that HRD1 and RFP2 (show TRIM13 Antibodies) contributes are required for the disposal of V247M alpha-sarcoglycan (show SGCA Antibodies) mutant.
Herp localizes to the endoplasmic reticulum-derived quality control compartment (ERQC) and recruits HRD1, which targets to endoplasmic reticulum associated degradation the substrate presented by the OS-9 lectin at the ERQC.
HRD1 and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5 (show ABCG5 Antibodies)/ABCG8 (show ABCG8 Antibodies).
identified Hrd1 as a novel E3 ubiquitin ligase (show MUL1 Antibodies) responsible for compromised Nrf2 (show GABPA Antibodies) response during liver cirrhosis
SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.
The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC Antibodies)-1b.
Data indicate that E3 ubiquitin-protein ligase (show UBE2K Antibodies) Hrd1 catalyzed ubiquitination and degradation of the transcriptional suppressor B lymphocyte-induced maturation protein 1 (BLIMP1 (show PRDM1 Antibodies)) to promote MHC-II antigen expression.
oxidative stress-induced (show SQSTM1 Antibodies) HRD1 insolubilization might be involved in a vicious cycle of increased amyloid beta production and amyloid beta-induced oxidative stress in Alzheimer's disease pathogenesis.
results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A (show SEC23A Antibodies) pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis
Synoviolin up-regulates amyloid beta production by targeting a negative regulator of gamma-secretase, Rer1 (show RER1 Antibodies), for degradation.
HRD1 is colocated with the neural stem cell marker protein nestin (show NES Antibodies) and glial fibrillary acidic protein (show GFAP Antibodies) in the endoplasmic reticulum membrane of the NSCs of the subventricular zone (SVZ astrocytes) but in the cell nucleus of in the dentate gyrus
these results clearly suggest that both beta-TrCP (show BTRC Antibodies)- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Antibodies) to maintain cellular homeostasis.
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
E3 ubiquitin-protein ligase synoviolin
, synovial apoptosis inhibitor 1, synoviolin
, HMG-coA reductase degradation 1 homolog
, synoviolin 1
, HRD1 protein