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The product of STX2 belongs to the syntaxin/epimorphin family of proteins. Additionally we are shipping Syntaxin 2 Antibodies (69) and Syntaxin 2 Kits (9) and many more products for this protein.
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TGF-beta (show TGFB1 Proteins), bFGF (show FGF2 Proteins) and epimorphin in the extracellular microenvironment cooperatively affect HSF (show HSF1 Proteins) behaviors under the control of a highly sulfated (show SULF1 Proteins) chondroitin sulfate
The effects of HIV/HCV co-infection on hepatic fibrosis might be mediated in part by epimorphin (EPM). Strategies to limit the expression of EPM might represent a novel therapeutic approach to prevent the progression of hepatic fibrosis during HIV/HCV co-infection.
Identify 3 loci associated with circulating tPA (show PLAT Proteins) levels, the PLAT (show PLAT Proteins) region, STXBP5 (show STXBP5 Proteins), and STX2. Functional studies implicate a novel role for STXBP5 (show STXBP5 Proteins) and STX2 in regulating tPA (show PLAT Proteins) release.
Epimorphin can revert ovarian cancer cells away from their mesenchymal phenotype and toward an epithelial phenotype.
epimorphin modulates the signaling pathways mediated by EGFR (show EGFR Proteins) for epidermal tissue organization
Genetic variation in STX2 is associated with von Willebrand factor:Ag levels in patients diagnosed with type 1 von Willebrand Disease.
EPM, secreted by activated stellate cells within stroma, promotes invasion and metastasis of hepatocellular cancer cells by activating MMP-9 (show MMP9 Proteins) expression through the FAK (show PTK2 Proteins)-ERK (show EPHB2 Proteins) pathway.
Genetic variability in STXBP5 (show STXBP5 Proteins) and STX2 affects both VWF (show VWF Proteins) concentration and activity in young individuals with premature arterial thrombosis.
Munc18b (show STXBP2 Proteins) binds to syntaxins 1A, 2, and 3 and regulates vesicle transport to the apical plasma membrane
These findings suggest that epimorphin contributes to repair of pulmonary fibrosis in nonspecific interstitial pneumonia, perhaps partly by inducing expression of matrix metalloproteinase 2 (show MMP2 Proteins), which is an important proteolytic factor in lung remodeling.
Syn-2 knockout mice exhibited paradoxical superior glucose homeostasis resulting from an enhanced insulin (show INS Proteins) secretion. The increase in insulin (show INS Proteins) exocytosis was attributed mainly to an enhanced recruitment of the larger pool of newcomer secretory granules (SGs (show SKI Proteins)) that undergoes no residence time on plasma membrane before fusion and, to a lesser extent, also the predocked SGs (show SKI Proteins).
The selectivity in syntaxin binding and apical protein redistribution further suggests that rab17 (show RAB17 Proteins) and syntaxin 2 mediate fusion of transcytotic vesicles at the apical surface.
It was concluded that Epim deletion inhibits polyposis in Apcmin/+ mice, associated with increased mucosal TGF-beta (show TGFB1 Proteins) signaling and decreased myofibroblast HGF (show HGF Proteins) expression and secretion.
Overexpression of Epim expression is associated with mammary carcinoma.
These results suggest that STX2 plays roles in transport and/or subcellular distribution of sulfoglycolipids.
Epimorphin regulates bile duct formation via effects on mitosis orientation
Epimorphin has a pivotal role in the repair of renal fibrosis by modulating both extracellular matrix (ECM (show MMRN1 Proteins)) degradation and its production.
syntaxin 2 enters the membrane of a fused zymogen granule after the opening of the fusion pore
Epimorphin is involved in tissue repair following a single injection of carbon tetrachloride, in which distribution and the quantity of epimorphin expression are important, particularly in maintaining hepatocyte function.
The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.
, Syntaxin 2
, syntaxin 1B2