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SNCG encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Additionally we are shipping SNCG Kits (9) and SNCG Proteins (3) and many more products for this protein.
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results indicate that gamma-synuclein is capable of binding to synaptic vesicles, but the mechanism of its interaction with these structures is fundamentally different from the mechanism proposed for alpha-synuclein (show SNCA Antibodies)
The results of this study suggested that gamma-synuclein is directly involved in the regulation of cognitive functions.
gamma-Synuclein binds synaptic vesicles but is unable to rescue the phenotype of CSPalpha-deficient mice.
gamma-synuclein is a regulator of lipid handling in adipocytes, the function of which is particularly important in conditions of nutrient excess
The loss of gamma-synuclein results in a significant increase in the level of orientation response in novel environment and decrease in the level of state anxiety.
gamma-Synuclein is necessary for the increased Mac-2 (show LGALS3 Antibodies) expression by myelination-transition-zone astrocytes during glaucoma.
The effects of gamma-synuclein deficiency on motor and peripheral sensory neurons were studied. Gamma-synuclein is dispensable for the development and function of the nervous system.
Immunohistochemistry demonstrates accelerated accumulation of gamma-synuclein in gracile axonal dystrophy mice. Gamma-synuclein appears in the gracile (show BCS1L Antibodies) nucleus at 3 weeks of age and was maintained until 32 weeks.
These data indicate the chaperone activity of SNCG on stimulation of steroid receptor (show ESR2 Antibodies) signaling in mammary gland.
Differences between alpha- and gamma-synuclein secondary structure propensities.
Study shows an overexpression of SNCG in bladder cancer (BC) tissues which correlates positively with neoplasm recurrence. SNCG seems a good marker to predict recurrence of BC, but not a reliable one for staging or prediction of survival rate.
down-regulation of gamma-synuclein reduces the protein level of PLCbeta but increases the transcript level over 40 fold
the conformational dynamics of ERalpha36 in the absence and presence of Hsp90 (show HSP90 Antibodies) and gammaSyn, is reported.
SNCG may promote MCF7 cell migration through activating the Erk (show EPHB2 Antibodies) pathway and breaking cell-cell junctions.
Data suggest that both BubR1 (show BUB1B Antibodies) and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.
High gamma-Synuclein expression is associated with invasiveness in colon adenocarcinoma.
Synuclein-gamma shares some, but not all, gene regulators with leptin (show LEP Antibodies) and is a PPARgamma (show PPARG Antibodies) target in adipocytes but not dorsal root ganglia neurons.
These results advance our understanding of the role of lncRNA-AK058003 as a regulator of hypoxia signaling, and this newly identified hypoxia/lncRNA-AK058003/SNCG pathway may help in the development of new therapeutics.
SNCG is highly expressed in bladder cancer tissue and its expression is stage-specific, but it is not helpful for predicting outcome in bladder cancer patients.
Results indicate that SNCG specifically interacts with Akt (show AKT1 Antibodies) and mTOR (show FRAP1 Antibodies) and protects Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) stability and function under stressful conditions when the activity of Hsp90 (show HSP90 Antibodies) is blocked.
This work reports the cloning and characterization of the porcine (Sus scrofa) gamma-synuclein cDNA (SNCG).
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development.
, sensory neuron synuclein
, breast cancer-specific gene 1 protein
, synuclein, gamma