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T Cell Immunoreceptor with Ig and ITIM Domains Proteins (TIGIT)

TIGIT encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. Additionally we are shipping TIGIT Antibodies (43) and TIGIT Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TIGIT 201633 Q495A1
TIGIT 100043314  
TIGIT 363784  
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Top TIGIT Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_HEK-293 Cells Human Fc Tag 50 μg Log in to see 21 to 31 Days
$385.00
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$547.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$806.30
Details

TIGIT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) , , , ,
, , ,
Rat (Rattus)

Top referenced TIGIT Proteins

  1. Human TIGIT Protein expressed in HEK-293 Cells - ABIN2181816 : Yu, Harden, Gonzalez, Francesco, Chiang, Irving, Tom, Ivelja, Refino, Clark, Eaton, Grogan: The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. in Nature immunology 2008 (PubMed)
    Show all 3 references for ABIN2181816

  2. Mouse (Murine) TIGIT Protein expressed in Human Cells - ABIN2008428 : Stanietsky, Simic, Arapovic, Toporik, Levy, Novik, Levine, Beiman, Dassa, Achdout, Stern-Ginossar, Tsukerman, Jonjic, Mandelboim: The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)

More Proteins for T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) Interaction Partners

Human T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) interaction partners

  1. TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization.

  2. implying that TIGIT exerts immunosuppressive effects by competing with DNAM-1 (show CD226 Proteins) for the same ligand, CD155 (show PVR Proteins)

  3. These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells

  4. This study shows that HBZ (show HBZ Proteins)-induced TIGIT plays a pivotal role in attenuating host immune responses and shaping a microenvironment favorable to human T-cell leukemia virus type 1.

  5. a novel mechanism that links TIGIT expression with NK-cell functional heterogeneity, and this mechanism might partially explain why individuals have different susceptibilities to infection, autoimmune disease, and cancer.

  6. Human regulatory T cells expressing the receptors TIGIT and CD226 (show CD226 Proteins) display widely divergent phenotypes in regard to expansion and activation.

  7. TIGIT and PD-1 (show PDCD1 Proteins) blockade additively increased proliferation, cytokine production, and degranulation of tumor-antigen-specific CD8 (show CD8A Proteins) T cells and CD8 (show CD8A Proteins) TILs. TIGIT and PD-1 (show PDCD1 Proteins) regulate the expansion and function of these T cells in melanoma.

  8. the TIGIT/FCRL3 (show FCRL3 Proteins) combination allows reliable identification of Helios (show ZNFN1A2 Proteins)(+) Treg cells even in highly activated conditions in vitro as well as in PBMCs of autoimmune patients.

  9. The results identify a bacterium-dependent, tumor-immune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleatum to inhibit immune cell activity via TIGIT.

  10. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (show CD226 Proteins) function when disrupting its homodimerization.

Mouse (Murine) T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) interaction partners

  1. TIGIT negatively regulates inflammation by altering macrophage phenotype.

  2. TIGIT signaling in Tregs directs their phenotype. It suppresses antitumor immunity via Tregs and not CD8 (show CD8A Proteins)+ T cells. TIGIT+ Tregs upregulated TIM-3 (show HAVCR2 Proteins) expression in tumor tissue. TIM-3 (show HAVCR2 Proteins) and TIGIT synergized to suppress antitumor immune responses.

  3. TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK-hepatocyte crosstalk.

  4. Findings suggest that TIGIT is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 (show CD226 Proteins) function when disrupting its homodimerization.

  5. TIGIT/PVR (show PVRL2 Proteins) ligation signaling mediates suppression of IFN-gamma (show IFNG Proteins) production via the NF-kappaB (show NFKB1 Proteins) pathway.

  6. expressed on a Treg cell subset that selectively suppresses Th1 (show HAND1 Proteins) and Th17 cells but not Th2 cells

  7. found that TIGIT was up-regulated selectively on NK cells and protected against liver injury in an acute adenovirus infection model in both an NK cell- and Kupffer cell-dependent manner

  8. findings show that TIGIT is expressed by NK cells, that it interacts specifically with PVR (show PVRL2 Proteins) and possibly with an additional unknown ligand found on PBMCs and that these interactions lead to the inhibition of NK-cell activities

  9. animals deficient in Vstm3 are more sensitive to autoimmune challenges indicating that this new member of the CD28 (show CD28 Proteins) family is an important regulator of T-cell responses

  10. TIGIT can act directly on T cells by attenuating T cell receptor-driven activation signals; loss of TIGIT results in hyperproliferative T cell responses and increased susceptibility to autoimmunity.

TIGIT Protein Profile

Protein Summary

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity\; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.

Gene names and symbols associated with TIGIT

  • T cell immunoreceptor with Ig and ITIM domains (TIGIT)
  • T cell immunoreceptor with Ig and ITIM domains (Tigit)
  • ENSMUSG00000071552 protein
  • RGD1563191 protein
  • VSIG9 protein
  • Vstm3 protein
  • WUCAM protein

Protein level used designations for TIGIT

T-cell immunoreceptor with Ig and ITIM domains , V-set and immunoglobulin domain containing 9 , V-set and immunoglobulin domain-containing protein 9 , V-set and transmembrane domain containing 3 , V-set and transmembrane domain-containing protein 3 , Washington University cell adhesion molecule

GENE ID SPECIES
201633 Homo sapiens
100043314 Mus musculus
363784 Rattus norvegicus
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