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anti-T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1) Antibodies

Through alternate splicing, TCIRG1 encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. Additionally we are shipping TCIRG1 Kits (5) and TCIRG1 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TCIRG1 293650  
TCIRG1 27060  
TCIRG1 10312 Q13488
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Top anti-TCIRG1 Antibodies at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 Antibody  at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of TCIRG1 in EL4 cell lysate with TCIRG1 antibody at 0.5 µg/mL in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 2 to 3 Days
$330.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of TCIRG1 expression in transfected 293T cell line by TCIRG1 MaxPab polyclonal antibody.Lane 1: TCIRG1 transfected lysate(68.80 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, WB   50 μL Log in to see 9 to 11 Days
$313.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 2 to 3 Days
$429.00
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 8 to 10 Days
$522.50
Details
Human Mouse Un-conjugated WB   50 μg Log in to see 11 to 16 Days
$553.14
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 11 to 16 Days
$553.14
Details
Human Mouse Un-conjugated ELISA   50 μL Log in to see 9 Days
$298.57
Details

TCIRG1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Mouse (Murine)


Human ,
,
,

Top referenced anti-TCIRG1 Antibodies

  1. Human Polyclonal TCIRG1 Primary Antibody for EIA, WB - ABIN1450004 : Toyomura, Oka, Yamaguchi, Wada, Futai: Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 references for ABIN1450004

  2. Human Monoclonal TCIRG1 Primary Antibody for ELISA, WB - ABIN564479 : Schulz, Dave, Stehberger, Chau, Wagner: Differential localization of vacuolar H+-ATPases containing a1, a2, a3, or a4 (ATP6V0A1-4) subunit isoforms along the nephron. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2007 (PubMed)
    Show all 3 references for ABIN564479

More Antibodies against TCIRG1 Interaction Partners

Mouse (Murine) T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1) interaction partners

  1. Here we show mice homozygous for R740S (R740S/R740S) of the Vacuolar-type H(+)-ATPases have more severe osteopetrosis (show CSF1 Antibodies) and die by postnatal day 14

  2. Luteolin can be effective in reducing bone resorption and that this effect of luteolin may be through disruption of osteoclast V-ATPase a3-d2 interaction.

  3. increased lysosomal pH in V ATPase a3 mutant mice osteoclasts leads to decreased NFATc1 (show NFATC1 Antibodies) signaling and nuclear translocation, resulting in a cell autonomous impairment of osteoclastogenesis in vitro.

  4. These results demonstrate that adeno (show ADORA2A Antibodies)-associated virus-mediated Atp6i/TIRC7 knockdown in periapical tissues can inhibit endodontic disease development, bone resorption, and inflammation.

  5. The N termini of a-subunit isoforms are involved in signaling between vacuolar H+-ATPase (show ATP6V1B2 Antibodies) (V-ATPase (show DNAH8 Antibodies)) and cytohesin-2 (show CYTH2 Antibodies)

  6. we report for the first time on biological effects mediated by a peptide corresponding to the C-terminus of Tirc7 protein, which interfere with monocytic differentiation pathways.

  7. Tcirg1, which is essential for osteoclasts to pump protons into the bone, is not appreciably expressed in maturation stage mouse ameloblasts.

  8. ocular phenotype of mice deficient in Tcirg1 function

  9. V-ATPase (show ATP6V1H Antibodies) localization and activity in kidney cells via direct PKA-dependent phosphorylation of the A subunit at Ser-175

  10. RANKL (show TNFSF11 Antibodies) treatment releases the negative regulation of PARP-1 (show PARP1 Antibodies) on Tcirg1 gene expression during osteoclastogenesis

Human T-Cell, Immune Regulator 1, ATPase, H+ Transporting, Lysosomal V0 Subunit A3 (TCIRG1) interaction partners

  1. an intronic region in TCIRG1 that seems to be particularly prone to splicing mutations, allowing the production of a small amount of protein sufficient to reduce the severity of the phenotype usually associated with TCIRG1 defects.

  2. TIRC7 might be involved in the pathogenesis of aplastic anemia.

  3. An A to T transversion in the fourth base of the intron 2 donor splice site (c.117+4A-->T) in TCIRG1 in the Ashkenazi Jewish (AJ) population was found to be responsible for osteopetrosis (show CSF1 Antibodies).

  4. TIRC7 might be associated with the pathogenesis of ITP (show ITPA Antibodies), and TIRC7 levels could be used as an indicator to evaluate patients' response to HD-DXM treatment.

  5. Increased expression of TIRC7 in plasma was associated with the severity of acute graft-versus-host disease.

  6. Data indicate that the effects of epiregulin (EREG (show EREG Antibodies)) and V-ATPase (show ATP6V1H Antibodies) (TCIRG1) single nucleotide polymorphism (SNP) on pulmonary tuberculosis susceptibility, to the extent that they exist, are dependent on gene-gene interactions in West African populations.

  7. TCIRG1-associated congenital neutropenia.

  8. analysis demonstrates that CLCN7 (show CLCN7 Antibodies) and TCIRG1 mutations differentially affect bone matrix mineralization, and that there is a need to modify the current classification of osteopetrosis (show CSF1 Antibodies)

  9. The function of vacuolar ATPase (V-ATPase (show DNAH8 Antibodies)) a (show ATP6V1A Antibodies) subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.

  10. Our data highlights the importance of two large genomic deletions and mutations in the 5' UTR (show UTS2R Antibodies) with respect to patient management and, more critically, to prenatal diagnosis

TCIRG1 Antigen Profile

Protein Summary

Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis.

Gene names and symbols associated with TCIRG1

  • T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (Tcirg1) antibody
  • T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 (Tcirg1) antibody
  • T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 (TCIRG1) antibody
  • a3 antibody
  • ATP6a3 antibody
  • Atp6i antibody
  • ATP6N1C antibody
  • ATP6V0A3 antibody
  • oc antibody
  • OC-116 antibody
  • OC-116kDa antibody
  • OC116 antibody
  • OPTB1 antibody
  • Stv1 antibody
  • TIRC7 antibody
  • Vph1 antibody

Protein level used designations for TCIRG1

ATPase, H+ transporting, lysosomal V0 protein a , T cell immune response cDNA7 protein , T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 , T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a , V-type proton ATPase 116 kDa subunit a , V-type proton ATPase 116 kDa subunit a isoform 3 , osteoclastic proton pump , v-ATPase 116-kDa , v-H+ATPase subunit a3 , ATPase, H+ transporting, lysosomal I , T-cell, immune regulator 1 , V-ATPase a3 , osteosclerotic , ATPase, H+ transporting, 116kD , OC-116 kDa , T-cell immune response cDNA 7 , V-ATPase 116-kDa , osteoclastic proton pump 116 kDa subunit , specific 116-kDa vacuolar proton pump subunit , vacuolar proton translocating ATPase 116 kDa subunit A

GENE ID SPECIES
293650 Rattus norvegicus
27060 Mus musculus
10312 Homo sapiens
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