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T-Cell Acute Lymphocytic Leukemia 1 Proteins (TAL1)

Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate. Additionally we are shipping TAL1 Antibodies (140) and TAL1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAL1 21349 P22091
TAL1 6886 P17542
Rat TAL1 TAL1 313507  
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Top TAL1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,830.67
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,871.00
Details
Yeast Takifugu rubripes His tag   1 mg Log in to see 56 to 66 Days
$3,017.67
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Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,089.17
Details

TAL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human

More Proteins for T-Cell Acute Lymphocytic Leukemia 1 (TAL1) Interaction Partners

Mouse (Murine) T-Cell Acute Lymphocytic Leukemia 1 (TAL1) interaction partners

  1. TAL1 and GATA1 (show GATA1 Proteins) form a precisely organized complex at a compound motif consisting of a TG 7 or 8 bp upstream of a WGATAA motif across thousands of genomic locations

  2. SCL-LMO1 (show LMO1 Proteins) upregulated a stem cell gene signature in DN3 thymocytes.

  3. TAL1 binds specifically to many genomic locations in multilineage precursor and erythroid progenitor cells, before GATA1 (show GATA1 Proteins) is produced abundantly.

  4. Ectopic Runx1 (show RUNX1 Proteins) expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

  5. Tal1 has a role in severe renal disease and patchy alopecia in Hairpatches (Hpt) mice

  6. Only Scl but not Map17 (show PDZK1IP1 Proteins) could rescue the Scl(Delta40/Delta40) ES phenotype.

  7. Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch (show NOTCH1 Proteins) pathways during the embryonic endothelial-to-hematopoietic transition.

  8. a novel role for GATA-4 (show GATA4 Proteins) and TAL1 to affect skeletal myogenic differentiation and EPO (show EPO Proteins) response via cross-talk with Sirt1 (show SIRT1 Proteins).

  9. Studies revealed an unexpected repressive role for Scl, as loss of Scl resulted in the generation of ectopic cardiomyocytes in yolk sac (show ADCY10 Proteins) vasculature and the endocardium; these results uncover remarkable developmental plasticity in embryonic vasculature and identify Scl as a key determinant of endothelial fate choice.

  10. Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.

Human T-Cell Acute Lymphocytic Leukemia 1 (TAL1) interaction partners

  1. Concurrent exogenous expression of three transcription factors, GATA1 (show GATA1 Proteins), FLI1 (show FLI1 Proteins) and TAL1, enables large-scale production of megakaryocytes from human pluripotent stem cells.

  2. analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter

  3. a successful induction of gamma-globin (show HBG1 Proteins) includes a reduction in BCL11A (show BCL11A Proteins), KLF1 (show KLF1 Proteins) and TAL1 expression.

  4. SCL (show KRT7 Proteins)-mediated transcriptional network enhances megakaryocytic specification of human embryonic stem cells.

  5. These results indicate that KLF1 (show KLF1 Proteins) plays a role in facilitating and/or stabilizing GATA-1 (show GATA1 Proteins) and TAL1 occupancy in the erythroid genes, contributing to the generation of active chromatin structure such as histone acetylation and chromatin looping

  6. Scl (show KRT7 Proteins) binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.

  7. SCL/TAL1 is located in the up-stream of MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway and partially regulates hematopoiesis by modulating the phosphorylation level of the key proteins in MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway.

  8. study found that heterozygous somatic mutations are acquired that introduce binding motifs for the MYB (show MYB Proteins) transcription factor in a precise noncoding site, which creates a super-enhancer upstream of the TAL1 oncogene (show RAB1A Proteins); MYB (show MYB Proteins) binds to this new site

  9. The results indicate that TAL1 plays a critical role in chromatin loop formation between the gamma-globin genes and locus control region, which is a critical step for the transcription of the gamma-globin genes.

  10. SIL (show PMEL Proteins)-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.

Zebrafish T-Cell Acute Lymphocytic Leukemia 1 (TAL1) interaction partners

  1. The latter data suggest that Stil play a role in retina cell proliferation through the Shh (show SHH Proteins) signal transduction pathway.

  2. Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions.

  3. Data suggest that a defined hemogenic endothelial population preset by scl-beta supports the deterministic emergence of HSCs, and unravel the cellular mechanisms by which scl isoforms regulate HSC (show FUT1 Proteins) development.

  4. Our studies establish a new connection between RA and scl during development that may participate in stem cell self-renewal and hematopoietic differentiation

  5. Ets1-related protein (show ETV2 Proteins) plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts.

  6. in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1-Lmo2 (show LMO2 Proteins)-induced haemangioblasts differentiate into endothelial cells

  7. Zebrafish scl has a role in hematopoietic and endothelial development, downstream of hemangioblast development.

  8. scl is especially critical for the development of arteries where adult hematopoietic stem cells emerge, implicating scl in the formation of hemogenic endothelium

  9. Scl participates in multiple processes requiring different levels and functions

  10. While scl-alpha and -beta are redundant for the initiation of primitive hematopoiesis, these two isoforms exert distinct functions in the regulation of primitive erythroid differentiation and definitive hematopoietic stem cell specification.

TAL1 Protein Profile

Protein Summary

Transcription factor that acts synergistically with lmo2 and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.

Gene names and symbols associated with TAL1

  • T cell acute lymphocytic leukemia 1 (Tal1)
  • T-cell acute lymphocytic leukemia 1 (TAL1)
  • T-cell acute lymphocytic leukemia 1 (Tal1)
  • T-cell acute lymphocytic leukemia 1 (tal1)
  • bHLHa17 protein
  • scl protein
  • SCL-alpha protein
  • SCL-beta protein
  • SCL/tal-1 protein
  • scl/tal1 protein
  • tal-1 protein
  • tcl5 protein
  • zgc:85605 protein

Protein level used designations for TAL1

T-cell acute lymphocytic leukemia 1 , T-cell acute lymphocytic leukemia protein 1 homolog , stem cell protein , T-cell acute lymphocytic leukemia protein 1 , T-cell leukemia/lymphoma protein 5 , class A basic helix-loop-helix protein 17 , tal-1 product , TAL-1 , stem cell leukaemia , stem cell leukemia protein SCL , xSCL , Avian SCL , stem-cell leukemia hematopoietic transcription factor , transcription factor , zSCL

GENE ID SPECIES
21349 Mus musculus
6886 Homo sapiens
610331 Canis lupus familiaris
518657 Bos taurus
313507 Rattus norvegicus
398028 Xenopus laevis
396298 Gallus gallus
30766 Danio rerio
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