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TAF15 encodes a member of the TET family of RNA-binding proteins. Additionally we are shipping TAF15 Antibodies (75) and many more products for this protein.
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TAF15 is required for a critical alternative splicing event of the zeta-1 subunit of the glutamate N-methyl-D-aspartate receptor (show GRIN3A Proteins) (Grin1 (show GRIN1 Proteins)) that controls the activity and trafficking of NR1 (show GRIN1 Proteins).
Aggregation of FET proteins FUS (show FUS Proteins), EWSR1 (show EWSR1 Proteins), and TAF15 mediate a pathological change in amyotrophic lateral sclerosis. (Review)
Studies provide evidence that FUS/TLS (show FUS Proteins), EWS (show EWSR1 Proteins) and TAF15 proteins play a major role in neurodegenerative disorders. (review).
O-GlcNAc (show OGT Proteins) glycosylation stoichiometry of TAF15
RNA binding by TAF-15 is dependent upon structural elements in the RNA rather than sequence.
our data suggest that TAF15 and TLS/FUS (show FUS Proteins) operate within similar but not identical hnRNP M (show HNRNPM Proteins)-TET protein complexes to influence the transcriptional or post-transcriptional output of a particular cell type.
Data indicate that distinct differences in proteins becoming Poly(ADP-ribose) PARylated upon various genotoxic insults are observed, exemplified by the PARylation of RNA-processing factors THRAP3 and TAF15 under oxidative stress.
TAF15 depletion inhibits growth & increases apoptosis. Its knockdown affects many genes involved in cell cycle & cell death. Among these, targets of microRNAs generated from the onco-miR-17 locus were overrepresented.
Data show that FUS (show FUS Proteins) and TAF15 locate to cellular stress granules to a larger extend than EWS (show EWSR1 Proteins). FET-protein stress granule association most likely is a downstream response to cellular stress.
The existence of a functionally discrete subset of U1 snRNP (show LSM2 Proteins) in association with TAF15 was suggested and provided further support for the involvement of U1 snRNP (show LSM2 Proteins) components in early steps of coordinated gene expression.
TAF15 plays a role in RNA transport and/or local RNA translation
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa
, TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA binding protein 56)
, TATA-binding protein-associated factor 2N
, RBP56/CSMF fusion
, TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
, TATA box-binding protein-associated factor 2N (RNA-binding protein 56)
, TBP-associated factor 15