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TAR DNA Binding Protein Proteins (TARDBP)

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Additionally we are shipping TAR DNA Binding Protein Antibodies (238) and TAR DNA Binding Protein Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
Rat TARDBP TARDBP 298648  
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Top TAR DNA Binding Protein Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 20 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,135.00
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,151.50
Details
HOST_Wheat germ Human GST tag   2 μg Log in to see 9 Days
$246.96
Details
HOST_Wheat germ Human GST tag   10 μg Log in to see 9 Days
$362.88
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$382.86
Details

TARDBP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced TAR DNA Binding Protein Proteins

  1. Human TARDBP Protein expressed in Escherichia coli (E. coli) - ABIN1098222 : Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995 (PubMed)

More Proteins for TAR DNA Binding Protein (TARDBP) Interaction Partners

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation.

  2. This study demonstrated that single nucleotide TDP-43 mutation within a Taiwanese family.

  3. Molecular analysis of pathological TDP-43 aggregates in amyotrophic lateral sclerosis brains.

  4. All patients with behavioural variant Frontotemporal dementia + motor neurone disease (MND) or MND showed plentiful p62 (show GTF2H1 Proteins)/TDP-43 positive inclusions in remaining anterior horn cells

  5. TDP-43 within neurons plays an essential role of mRNA transport into distal neurites for local translation, and thus, dysfunctions of TDP-43 cause neural diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

  6. a combination of TDP-43 and an motor neuron degeneration factors can be used to reflect abnormal RNA metabolism in WBCs and thus be useful as ALS-onset biomarkers.

  7. both phosphorylated and calpain-cleaved TDP-43 fragments persist intracellularly for a length of time that is sufficient for self-aggregation, thereby serving as seeds for inclusions.

  8. misfolded TDP-43 is cleared by VHL (show VHL Proteins)/CUL2 (show CUL2 Proteins) in a step-wise manner via fragmentation.

  9. TDP-43 functions within a network of hnRNP (show HNRNPC Proteins) proteins to inhibit the production of a truncated human SORT1 (show SORT1 Proteins) receptor.

  10. These observations point to the need to elucidate the novel sequestration mechanism and details of the toxicity of the misfolded and aggregation-prone TDP43 CTFs (as well as the RNA binding and nuclear retention) in order to identify possible preventive interventions against ALS.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. TDP-43 functions within a network of hnRNP (show HNRNPH2 Proteins) proteins to inhibit the production of a truncated human SORT1 (show SORT1 Proteins) receptor.

  2. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  3. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  4. UBQLN2 (show UBQLN2 Proteins) dysregulation in neurons can drive NF-kappaB (show NFKB1 Proteins) activation and cytosolic TDP-43 aggregation.

  5. These findings demonstrate a role for PABPN1 (show PABPN1 Proteins) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  6. identifies DDX58 (show DDX58 Proteins) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

  7. Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.

  8. we observed a glial reaction and an activity-dependent modification of Shh (show SHH Proteins), Noggin (show NOG Proteins), and Numb (show NUMB Proteins) proteins. we found that Shh (show SHH Proteins) and Noggin (show NOG Proteins) could affect motor performance and that these proteins could be associated with both TDP-43 and Numb (show NUMB Proteins)

  9. The ability of TDP-43 to promote CD14 (show CD14 Proteins)-mediated activation of microglial NF-kappaB (show NFKB1 Proteins) and AP-1 (show JUN Proteins) pathways, as well as the NLRP3 (show NLRP3 Proteins) inflammasome.

  10. Depletion of TDP-43 leads to a dramatic reduction in the RNA processing and the protein levels of IL-6 (show IL6 Proteins) in serum.

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (show CNBP Proteins) tardbp and RNA binding protein fus (show FUS Proteins).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (show FUS Proteins) act in a pathogenic pathway that is independent of SOD1 (show SOD1 Proteins).

TAR DNA Binding Protein (TARDBP) Protein Profile

Protein Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Gene names and symbols associated with TARDBP

  • TAR DNA binding protein (TARDBP)
  • Tardbp protein (tardbp)
  • TAR DNA binding protein (tardbp)
  • TAR DNA binding protein (Tardbp)
  • TAR DNA-binding protein 43-like (LOC100621383)
  • 1190002A23Rik protein
  • ALS10 protein
  • C85084 protein
  • DKFZp459I2127 protein
  • tardbp protein
  • TDP-43 protein
  • Tdp43 protein
  • wu:fb77f02 protein
  • wu:fc52g10 protein

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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