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HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Additionally we are shipping TAR DNA Binding Protein Antibodies (241) and TAR DNA Binding Protein Kits (23) and many more products for this protein.
Showing 10 out of 14 products:
Human TARDBP Protein expressed in Escherichia coli (E. coli) - ABIN1098222
Ou, Wu, Harrich, García-Martínez, Gaynor: Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. in Journal of virology 1995
The data indicated that TDP-43/p35 (show ANXA1 Proteins) contributed to stress granule formation by promoting RACK1 (show GNB2L1 Proteins) expression. The study sheds new light on post-transcriptional regulation and apoptosis in osteoarthritis (OA) by RACK1 (show GNB2L1 Proteins), which is a potential treatment strategy for OA.
Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation.
This study demonstrated that single nucleotide TDP-43 mutation within a Taiwanese family.
Molecular analysis of pathological TDP-43 aggregates in amyotrophic lateral sclerosis brains.
All patients with behavioural variant Frontotemporal dementia + motor neurone disease (MND) or MND showed plentiful p62 (show GTF2H1 Proteins)/TDP-43 positive inclusions in remaining anterior horn cells
TDP-43 within neurons plays an essential role of mRNA transport into distal neurites for local translation, and thus, dysfunctions of TDP-43 cause neural diseases such as amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
a combination of TDP-43 and an motor neuron degeneration factors can be used to reflect abnormal RNA metabolism in WBCs and thus be useful as ALS-onset biomarkers.
both phosphorylated and calpain-cleaved TDP-43 fragments persist intracellularly for a length of time that is sufficient for self-aggregation, thereby serving as seeds for inclusions.
misfolded TDP-43 is cleared by VHL (show VHL Proteins)/CUL2 (show CUL2 Proteins) in a step-wise manner via fragmentation.
TDP-43 functions within a network of hnRNP (show HNRNPC Proteins) proteins to inhibit the production of a truncated human SORT1 (show SORT1 Proteins) receptor.
TDP-43 functions within a network of hnRNP (show HNRNPH2 Proteins) proteins to inhibit the production of a truncated human SORT1 (show SORT1 Proteins) receptor.
Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon
This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.
UBQLN2 (show UBQLN2 Proteins) dysregulation in neurons can drive NF-kappaB (show NFKB1 Proteins) activation and cytosolic TDP-43 aggregation.
These findings demonstrate a role for PABPN1 (show PABPN1 Proteins) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.
identifies DDX58 (show DDX58 Proteins) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1
Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.
we observed a glial reaction and an activity-dependent modification of Shh (show SHH Proteins), Noggin (show NOG Proteins), and Numb (show NUMB Proteins) proteins. we found that Shh (show SHH Proteins) and Noggin (show NOG Proteins) could affect motor performance and that these proteins could be associated with both TDP-43 and Numb (show NUMB Proteins)
The ability of TDP-43 to promote CD14 (show CD14 Proteins)-mediated activation of microglial NF-kappaB (show NFKB1 Proteins) and AP-1 (show JUN Proteins) pathways, as well as the NLRP3 (show NLRP3 Proteins) inflammasome.
Depletion of TDP-43 leads to a dramatic reduction in the RNA processing and the protein levels of IL-6 (show IL6 Proteins) in serum.
Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (show CNBP Proteins) tardbp and RNA binding protein fus (show FUS Proteins).
Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.
TARDBP and FUS (show FUS Proteins) act in a pathogenic pathway that is independent of SOD1 (show SOD1 Proteins).
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
TAR DNA binding protein
, TAR DNA-binding protein 43
, Tardbp protein
, TAR DNA-binding protein-43