TSC22 Domain Family, Member 3 Proteins (TSC22D3)

The protein encoded by TSC22D3 shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. Additionally we are shipping TSC22D3 Antibodies (103) and TSC22D3 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSC22D3 1831 Q99576
TSC22D3 14605 Q9Z2S7
TSC22D3 83514 Q9EQZ1
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Top TSC22D3 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$669.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$685.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
$2,102.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,280.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 60 to 71 Days
$2,280.67
Details

TSC22D3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
,
Rat (Rattus)

Top referenced TSC22D3 Proteins

  1. Human TSC22D3 Protein expressed in Escherichia coli (E. coli) - ABIN1098422 : Asselin-Labat, David, Biola-Vidamment, Lecoeuche, Zennaro, Bertoglio, Pallardy: GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. in Blood 2004 (PubMed)
    Show all 2 references for 1098422

More Proteins for TSC22 Domain Family, Member 3 (TSC22D3) Interaction Partners

Zebrafish TSC22 Domain Family, Member 3 (TSC22D3) interaction partners

  1. Zebrafish tsc22d3 is a ventralizing gene and plays a role in early embryogenesis

Human TSC22 Domain Family, Member 3 (TSC22D3) interaction partners

  1. TSC22D3 gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.

  2. Overall, these results suggest that GILZ antagonizes the pro-inflammatory effects of TNFa (show TNF Proteins) in human adipocytes, and its downregulation in obesity may contribute to adipose inflammation and dysregulated adipokine production, and thereby systemic metabolism.

  3. Under endoplasmic reticulum stress conditions, overexpression of GILZ significantly reduced activation of mitochondrial pathway of apoptosis by maintaining Bcl-xl (show BCL2L1 Proteins) level. GILZ protein affects the unfolded protein response signaling shifting the balance towards pro-survival signals as judged by down-regulation of CHOP (show DDIT3 Proteins), ATF4 (show ATF4 Proteins), XBP1s mRNA and increase in GRP78 (show HSPA5 Proteins) protein level.

  4. results reveal GILZ to be a new actor in apoptosis regulation in neutrophil-like cells involving JNK (show MAPK8 Proteins) and Mcl-1 (show MCL1 Proteins).

  5. GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus.

  6. our data suggest that GILZ is a key regulator of macrophage functions.

  7. L-GILZ stabilizes p53 (show TP53 Proteins) proteins by decreasing p53 (show TP53 Proteins) ubiquitination and increasing MDM2 (show MDM2 Proteins) ubiquitination.

  8. The N-terminal part of L-GILZ protein is responsible for Ras/L-GILZ protein-to-protein interaction, important for the control of proliferation rate of spermatogonia.

  9. PUVA directly stimulates GILZ expression.

  10. Data show a diminished expression of the anti-inflammatory mediator GILZ in the inflamed vasculature and indicate that GILZ downregulation requires the mRNA binding protein ZFP36 (show ZFP36 Proteins).

Mouse (Murine) TSC22 Domain Family, Member 3 (TSC22D3) interaction partners

  1. GILZ promotes potassium secretion by inhibiting sodium-chloride cotransporter (show SLC12A3 Proteins) and enhancing distal sodium delivery to the epithelial sodium channel.

  2. HuR (show ELAVL1 Proteins) overexpression led to increased GILZ protein levels but had no effect on GILZ mRNA expression.

  3. The present findings shed light on the role of GILZ in the mechanism of induction of Anxa1 (show ANXA1 Proteins) by GCs (show UGCG Proteins). As Anxa1 (show ANXA1 Proteins) is an important protein for the resolution of inflammatory response, GILZ may represent a new pharmacologic target for treatment of inflammatory diseases.

  4. Role of glucocorticoid-induced leucine zipper (GILZ) in inflammatory bone loss

  5. marked reduction in cardiac GILZ in association with increased Th-17 cells accompanied with marked disruption of mitochondrial membrane potential and increased apoptotic/necrotic cell death in hearts subjected to myocardial infarction

  6. results identify GILZ as an endogenous inhibitor of macropinocytosis in DCs, the action of which contributes to the fine-tuning of Ag cross-presentation.

  7. Obesity is associated with a downregulation of the Gr-Gilz axis in kupffer cells, which promotes liver inflammation.

  8. GILZ is a non-redundant regulator of B cell activity, with important potential clinical implications in systemic lupus erythematosus.

  9. Data show that glucocorticoid-induced leucine zipper (GILZ) maintains a threshold for activation of Th17 responses and interleukin 17 (IL-17 (show IL17A Proteins))-dependent pathology.

  10. Lack of glucocorticoid-induced leucine zipper deregulates B-cell survival and results in B-cell lymphocytosis

TSC22D3 Protein Profile

Protein Summary

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with TSC22D3

  • TSC22 domain family, member 3 (tsc22d3)
  • TSC22 domain family, member 3 (TSC22D3)
  • TSC22 domain family, member 3 (LOC100227519)
  • TSC22 domain family, member 3 (LOC100356656)
  • TSC22 domain family, member 3 (Tsc22d3)
  • DIP protein
  • DSIP protein
  • Dsip1 protein
  • Dsipi protein
  • Gilz protein
  • hDIP protein
  • MGC53285 protein
  • Tilz3 protein
  • TSC-22R protein
  • TSC22D3 protein
  • zgc:65831 protein
  • zgc:77028 protein

Protein level used designations for TSC22D3

TSC22 domain family, member 3 , glucocorticoid-induced leucine zipper , TSC22 domain family protein 3 , gilz , glucocorticoid-induced leucine zipper protein , DSIP-immunoreactive leucine zipper protein , DSIP-immunoreactive peptide , TSC-22 related protein , TSC-22-like protein , TSC-22-related protein , delta sleep inducing peptide, immunoreactor , delta sleep-inducing peptide immunoreactor , TSC22 domain family 3 , TSC22-related inducible leucine zipper 3 , TSC22-related-inducible leucine zipper 3 , long glucocorticoid-induced leucine zipper protein , DIP protein , Glucocorticoid-induced leucine zipper protein , delta-sleep-inducing peptide

GENE ID SPECIES
379978 Xenopus laevis
393541 Danio rerio
492057 Canis lupus familiaris
702656 Macaca mulatta
739684 Pan troglodytes
768091 Gallus gallus
100125309 Bos taurus
100145088 Xenopus (Silurana) tropicalis
100227519 Taeniopygia guttata
100356656 Oryctolagus cuniculus
1831 Homo sapiens
14605 Mus musculus
83514 Rattus norvegicus
100517321 Sus scrofa
100171736 Pongo abelii
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