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Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Kits (11) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Proteins (3) and many more products for this protein.
Showing 10 out of 58 products:
Human Polyclonal TNKS Primary Antibody for EIA, WB - ABIN955072
Hatsugai, Ohishi, Sugimoto, Seimiya: Tankyrase-1 assembly to large protein complexes blocks its telomeric function. in FEBS letters 2010
Show all 2 references for ABIN955072
Chicken Polyclonal TNKS Primary Antibody for IHC, WB - ABIN2778110
Baynam, Goldblatt, Walpole: Deletion of 8p23.1 with features of Cornelia de Lange syndrome and congenital diaphragmatic hernia and a review of deletions of 8p23.1 to 8pter? A further locus for Cornelia de Lange syndrome. in American journal of medical genetics. Part A 2008
Human Polyclonal TNKS Primary Antibody for WB - ABIN401535
Seimiya, Muramatsu, Ohishi, Tsuruo: Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. in Cancer cell 2005
HCMV modulates the activity of TNKS to induce Axin1 (show AXIN1 Antibodies), resulting in inhibition of the beta-catenin (show CTNNB1 Antibodies) pathway.
Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 Antibodies)/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling addicted tumors.
TNKS1 SNPs (rs11991621 rs10503380, and rs7015700) were associated with non-small cell lung cance risk, whereas rs6601328 and rs12541709 inversely associated with risk
Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC (show FAM126A Antibodies) with aberrant WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.
TNKS1 is recruited to DNA lesions by MDC1 (show MDC1 Antibodies) and promotes homologous recombination in response to DNA double strand breaks.
Copy number deletion on TNKS was associated with a 1.37-fold decreased risk for osteoarthritis.
tankyrase-mediated PARsylation is promoted by nutritional energy stimulated NAD+ in insulinoma (show RPS15 Antibodies) cells
Data indicate that tankyrase (Tnks) inhibitors impact telomere length maintenance independently of their affects on Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
We demonstrate for the first time that tankyrase inhibition triggers reduced cell growth and differentiation of OS cells
Studies show a significant interaction of IWR1 with acidic and polar residues (Asp (show ASIP Antibodies) and Tyr (show TYR Antibodies)) in the hydrophobic region at the induced pocket of TNKS1/TNKS2 (show TNKS2 Antibodies). These two residues are the key for the mechanism of inhibition of TNKS proteins.
analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling
Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 Antibodies) ligands.
Collectively, our data suggest that GSK3 contributes to mitotic tankyrase phosphorylation.
insulin (show INS Antibodies)-stimulated insulin-responsive aminopeptidase (show LNPEP Antibodies) translocation remained intact despite substantial GLUT4 (show SLC2A4 Antibodies) knockdown
tankyrase1 is a poly(ADP-ribose) polymerase (show PARP1 Antibodies) with roles in telomere length control by the TRF1 (show TERF1 Antibodies) component of the shelterin complex
Tankyrase 1 is essential but redundant for mouse embryonic development
Tankyrase-deficient mice exhibit increases in energy expenditure, fatty acid oxidation, and insulin (show INS Antibodies)-stimulated glucose utilization.
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.
, tankyrase 1
, ADP-ribosyltransferase diphtheria toxin-like 5
, TRF1-interacting ankyrin-related ADP-ribose polymerase
, poly [ADP-ribose] polymerase 5A
, tankyrase I
, TRF1-interacting ankyrin-related ADP-ribose polymerase 1