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anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) Antibodies

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Additionally we are shipping Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Kits (11) and Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TNKS 8658 O95271
TNKS 21951 Q6PFX9
TNKS 290794  
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Top anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Antibodies at antibodies-online.com

Showing 10 out of 58 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB TNKS Antibody (N-term) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the TNKS antibody detected the TNKS protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB Human Small Intestine, submucosal plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$676.50
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to TNKS on formalin-fixed paraffin-embedded human lymph node (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged TNKS is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

TNKS Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
, , ,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Antibodies

  1. Human Polyclonal TNKS Primary Antibody for EIA, WB - ABIN955072 : Hatsugai, Ohishi, Sugimoto, Seimiya: Tankyrase-1 assembly to large protein complexes blocks its telomeric function. in FEBS letters 2010 (PubMed)
    Show all 2 references for ABIN955072

  2. Chicken Polyclonal TNKS Primary Antibody for IHC, WB - ABIN2778110 : Baynam, Goldblatt, Walpole: Deletion of 8p23.1 with features of Cornelia de Lange syndrome and congenital diaphragmatic hernia and a review of deletions of 8p23.1 to 8pter? A further locus for Cornelia de Lange syndrome. in American journal of medical genetics. Part A 2008 (PubMed)

  3. Human Polyclonal TNKS Primary Antibody for WB - ABIN401535 : Seimiya, Muramatsu, Ohishi, Tsuruo: Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. in Cancer cell 2005 (PubMed)

More Antibodies against Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Interaction Partners

Human Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. HCMV modulates the activity of TNKS to induce Axin1 (show AXIN1 Antibodies), resulting in inhibition of the beta-catenin (show CTNNB1 Antibodies) pathway.

  2. Data show that E7449 represents a dual Poly(ADP-ribose) Polymerase 1 (show PARP1 Antibodies)/2 and tankyrase 1/2 inhibitor which has the advantage of targeting Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling addicted tumors.

  3. TNKS1 SNPs (rs11991621 rs10503380, and rs7015700) were associated with non-small cell lung cance risk, whereas rs6601328 and rs12541709 inversely associated with risk

  4. Tankyrase inhibition is a potential therapeutic approach for treating a subgroup HCC (show FAM126A Antibodies) with aberrant WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway.

  5. TNKS1 is recruited to DNA lesions by MDC1 (show MDC1 Antibodies) and promotes homologous recombination in response to DNA double strand breaks.

  6. Copy number deletion on TNKS was associated with a 1.37-fold decreased risk for osteoarthritis.

  7. tankyrase-mediated PARsylation is promoted by nutritional energy stimulated NAD+ in insulinoma (show RPS15 Antibodies) cells

  8. Data indicate that tankyrase (Tnks) inhibitors impact telomere length maintenance independently of their affects on Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.

  9. We demonstrate for the first time that tankyrase inhibition triggers reduced cell growth and differentiation of OS cells

  10. Studies show a significant interaction of IWR1 with acidic and polar residues (Asp (show ASIP Antibodies) and Tyr (show TYR Antibodies)) in the hydrophobic region at the induced pocket of TNKS1/TNKS2 (show TNKS2 Antibodies). These two residues are the key for the mechanism of inhibition of TNKS proteins.

Mouse (Murine) Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) interaction partners

  1. analyses also reveal the structural basis for TNKS substrate recruitment, and shed light on the overall structure of TNKS that should help in developing specific inhibitors of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling

  2. Data show that Tnks1 and 2 are broadly expressed during mouse development and are essential during kidney and lung development. In the kidney, blockage of tankyrase activity phenocopies the effect of blocking production of all Wnt (show WNT2 Antibodies) ligands.

  3. Collectively, our data suggest that GSK3 contributes to mitotic tankyrase phosphorylation.

  4. insulin (show INS Antibodies)-stimulated insulin-responsive aminopeptidase (show LNPEP Antibodies) translocation remained intact despite substantial GLUT4 (show SLC2A4 Antibodies) knockdown

  5. tankyrase1 is a poly(ADP-ribose) polymerase (show PARP1 Antibodies) with roles in telomere length control by the TRF1 (show TERF1 Antibodies) component of the shelterin complex

  6. Tankyrase 1 is essential but redundant for mouse embryonic development

  7. Tankyrase-deficient mice exhibit increases in energy expenditure, fatty acid oxidation, and insulin (show INS Antibodies)-stimulated glucose utilization.

Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase (TNKS) Antigen Profile

Protein Summary

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.

Gene names and symbols associated with TNKS

  • si:ch211-155m12.3 (si:ch211-155m12.3) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (TNKS) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (Tnks) antibody
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase (tnks) antibody
  • 4930554K12Rik antibody
  • AI662855 antibody
  • ARTD5 antibody
  • C86528 antibody
  • D130072O21Rik antibody
  • mTNKS1 antibody
  • PARP-5a antibody
  • PARP5A antibody
  • PARPL antibody
  • pART5 antibody
  • TANK1 antibody
  • tankyrase-1 antibody
  • TIN1 antibody
  • TINF1 antibody
  • TNKS1 antibody
  • wu:fe02c12 antibody

Protein level used designations for TNKS

fe02c12 , tankyrase 1 , ADP-ribosyltransferase diphtheria toxin-like 5 , TANK1 , TNKS-1 , TRF1-interacting ankyrin-related ADP-ribose polymerase , poly [ADP-ribose] polymerase 5A , tankyrase I , tankyrase-1 , TRF1-interacting ankyrin-related ADP-ribose polymerase 1

GENE ID SPECIES
567533 Danio rerio
8658 Homo sapiens
21951 Mus musculus
100036993 Xenopus laevis
374252 Gallus gallus
475603 Canis lupus familiaris
535030 Bos taurus
290794 Rattus norvegicus
100153228 Sus scrofa
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