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TSHZ1 encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. Additionally we are shipping Teashirt Zinc Finger Homeobox 1 Antibodies (47) and many more products for this protein.
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Expression of tsh1 (homologue of Drosophila homeotic gene teashirt) is detected at the 2-somite stage at the anterior end of the spinal cord, expression then expands and by the prim-5 stage tsh1 transcripts are detected throughout spinal cord.
Adult Tshz1(+/-) mice display glucose intolerance due to defects in glucose-stimulated insulin secretion associated with reduced Pdx1 and Clec16a expression in Tshz1(+/-) islets.
three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
In the craniofacial region, loss of Tshz1 function leads to specific malformations of middle ear components, including the malleus and the tympanic ring.
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 (show SH2B3 Proteins) and TSHZ1.
TSHZ1 levels are reduced in human islets of donors with type 2 diabetes
TSHZ1 is a key regulator of mammalian olfactory bulb development and function and controls the expression of PROKR2 (show PROKR2 Proteins).
Together, these results demonstrate that hemizygosity of TSHZ1 leads to congenital aural atresia as a result of haploinsufficiency
a significant up-regulation of BORIS (show CTCFL Proteins) (p<0.001) and TSHZ1 transcripts (p<0.05) for JAs (show TAP2 Proteins) compared to nasal mucosa.
This publication characterizes the mouse ortholog of the human teashirt zinc finger homeobox 1 gene and proposes that the human gene may be a candidate gene for CAA syndrome.
This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome.
serologically defined colon cancer antigen 33
, teashirt homolog 1
, teashirt zinc finger family member 1
, teashirt zinc finger homeobox 1
, SDCCAG33 variant protein-like
, teashirt family zinc finger 1
, teashirt-like zinc finger protein
, serologically defined colon cancer antigen 3 homolog
, antigen NY-CO-33