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The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. Additionally we are shipping Thrombomodulin Antibodies (251) and Thrombomodulin Proteins (23) and many more products for this protein.
Showing 10 out of 88 products:
Mouse (Murine) Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN424235
Raeven, Salibasic, Drechsler, Weixelbaumer, Jafarmadar, van Griensven, Bahrami, Osuchowski: A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis. in PLoS ONE 2013
Show all 5 references for ABIN424235
Human Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN415045
Tsimaris, Deligeoroglou, Athanasopoulos, Economou, Stamatelopoulos, Rizos, Papamichael, Lambrinoudaki, Mastorakos, Creatsas: The effect of hormone therapy on biochemical and ultrasound parameters associated with atherosclerosis in 46,XY DSD individuals with female phenotype. in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2014
Show all 5 references for ABIN415045
Rat (Rattus) Thrombomodulin ELISA Kit for Sandwich ELISA - ABIN416379
Kaija, Pakanen, Uusitalo, Nikkilä, Kortelainen, Porvari: Changes in cardiac thrombomodulin and heat shock transcription factor 1 expression and peripheral thrombomodulin and catecholamines during hypothermia in rats. in Stress (Amsterdam, Netherlands) 2014
CORM-2 protects human umbilical vein endothelial cells from lipopolysaccharide-induced injury, by way of suppressing NF-kappaB (show NFKB1 ELISA Kits) activity, which downregulates TM and EPCR (show PROCR ELISA Kits) mRNAs. It also decreases MMP-2 (show MMP2 ELISA Kits) expression and prevents the shedding of TM and EPCR (show PROCR ELISA Kits) from the surface of endothelial cells, so as to preserve their protective effect.
The results demonstrate that the LFA-1 (show ITGAL ELISA Kits) and Mac-1 (show ITGAM ELISA Kits) integrins on leukocytes bind to thrombomodulin (TM), thereby establishing the molecular and structural basis underlying LFA-1 (show ITGAL ELISA Kits) and Mac-1 (show ITGAM ELISA Kits) integrin interaction with TM on endothelial cells.
Human thrombomodulin transgenic aortic endothelial cells are less sensitive to activation by either HMGB1 or hTNFalpha, an effect that appears to be dependent on the lectin-like domain of TBM.
In placenta of patients with preeclampsia, we detected abnormal expression of F3 and THBD with increased protein and mRNA levels. The role of these molecules in the pathogenesis of this disease and in alterations of hemostatic and histopathological aspects of placentas need further studying.
TM up-regulated E-cadherin (show CDH1 ELISA Kits) but down-regulated N-cadherin (show CDH2 ELISA Kits) expression, resulting in reversal of epithelial-mesenchymal transition (EMT (show ITK ELISA Kits)) in the lung cancer cells.
High serum thrombomodulin expression is associated with non-alcoholic fatty liver disease.
results do not suggest a predictive role for THBD c.1418C>T polymorphism in VTE recurrence
R12 (show GPR17 ELISA Kits) is a critical residue for the activation of TAFI (show CPB2 ELISA Kits) by thrombin (show F2 ELISA Kits)-thrombomodulin
Study detected a statistically significant positive correlation between expanded disability status scale scores and thrombomodulin levels (p<0.01) and a 10% positive correlation between expanded disability status scale scores and APC (show APC ELISA Kits) levels in multiple sclerosis patients
Case Report: thrombotic microangiopathy with mutations in complement factor I (show CFI ELISA Kits) and thrombomodulin.
the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis
Identified Nur77 (show NR4A1 ELISA Kits)/Nor1 (show NR4A3 ELISA Kits) as novel regulators of thrombomodulin expression and function in vascular endothelial cells.
TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF (show PDGFA ELISA Kits)-BB. In addition, rTMD23 has therapeutic potential in corneal injury
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice
the recombinant epidermal growth factor (show EGF ELISA Kits)-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice
Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells.
Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 (show HMGB1 ELISA Kits) and an independent mechanism.
The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice.
Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism.
TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage.
Atorvastin induces THBD expression in the aorta of cholesterol-fed rabbits.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
, CD141 antigen
, snoRNA MBII-339