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Transcobalamin II Proteins (TCN2)

TCN2 encodes a member of the vitamin B12-binding protein family. Additionally we are shipping Transcobalamin II Antibodies (43) and Transcobalamin II Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCN2 21452 O88968
TCN2 64365 Q9R0D6
TCN2 6948 P20062
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Top Transcobalamin II Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_CHO Cells Human His tag 50 μg Log in to see 20 to 21 Days
$272.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,135.00
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$3,135.00
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,151.50
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$584.38
Details

TCN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus) ,
,
Human , , , , ,
, ,

Top referenced Transcobalamin II Proteins

  1. Mouse (Murine) TCN2 Protein expressed in Human Cells - ABIN2008170 : Seetharam, Li: Transcobalamin II and its cell surface receptor. in Vitamins and hormones 2000 (PubMed)

More Proteins for Transcobalamin II (TCN2) Interaction Partners

Human Transcobalamin II (TCN2) interaction partners

  1. The mutation does not seem to interfere with the function of TC, but the mutation may well explain the low level of holoTC detected by the Abbott assay. The results underscores that mutations of TCN2 have to be considered when implausible holoTC results are obtained.

  2. 4 patients with transcobalamin II deficiency were found to have novel mutations, of whom 2 had the same large deletion (homozygous c.1106+1516-1222+1231del). One had c.1107- 347_1222+981delin 364. Another had homozygous c.106C>T. (Q36X).

  3. There were no other associations between single -nucleotide polymorphisms and the efficacy of MTX (show MTX1 Proteins) treatment. CONCLUSIONS: The MTHFR (show MTHFR Proteins) 677CC and GGH (show GGH Proteins) 401TT and CT genotypes were associated with a reduction in the number of MTX (show MTX1 Proteins)-related adverse events.

  4. Report TCN2 mutations causing transcobalamin deficiency in an Indian patient.

  5. Although not significant when corrected for multiple testing, eight single nucleotide polymorphisms (SNPs) in two genes, transcobalamin II (TCN2) and the transcobalamin II-receptor (TCblR (show CD320 Proteins)), were found to influence several clinical traits of cobalamin deficiency.

  6. In Asian populations, the investigated polymorphisms mapping at TCN2 and CBS (show CBS Proteins) genes did not provide any evidence of association with cleft lip/cleftpalate.

  7. TCN2 776C --> G polymorphism is negatively associated with Alzheimer's type dementia, suggesting a protective role against the disease in subjects with the 5, 10-methylenetetrahydrofolate reductase (show MTHFR Proteins) 1298AA genotype

  8. Transcobalamin II (TCN2 67A>G and TCN2 776C>G) and transcobalamin II receptor (TCblR (show CD320 Proteins) 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion

  9. neither MTHFD (show MTHFD1 Proteins) G1958A nor TC C776G polymorphisms are an independent risk factor for Down syndrome. However, the combined MTHFD (show MTHFD1 Proteins)/MTHFR (show MTHFR Proteins), TC/MTHFR (show MTHFR Proteins) genotypes play a role in the risk of bearing a Down syndrome child in the Chinese population.

  10. Report TCN2 mutations causing transcobalamin deficiency in a family.

Cow (Bovine) Transcobalamin II (TCN2) interaction partners

  1. study investigated crystallographically the beta-ligand exchange on Cbl bound to transcobalamin (TC) by crystallization of bovine holo-TC in the presence of either cyanide or sulfite

Transcobalamin II (TCN2) Protein Profile

Protein Summary

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Transcobalamin II Proteins (TCN2)

  • transcobalamin 2 (Tcn2)
  • transcobalamin II (TCN2)
  • AW208754 protein
  • D22S676 protein
  • D22S750 protein
  • II protein
  • TC protein
  • TC-2 protein
  • TC2 protein
  • TCII protein
  • TC II protein
  • Tcn-2 protein
  • Tcn2p protein

Protein level used designations for Transcobalamin II Proteins (TCN2)

TC II , TC-2 , TCII , transcobalamin II , transcobalamin-2 , macrocytic anemia , transcobalamin II; macrocytic anemia , vitamin B12-binding protein 2

GENE ID SPECIES
21452 Mus musculus
64365 Rattus norvegicus
6948 Homo sapiens
281518 Bos taurus
100171681 Pongo abelii
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