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Transcription Elongation Factor SPT5 Proteins (SUPT5H)

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. Additionally we are shipping Transcription Elongation Factor SPT5 Antibodies (43) and Transcription Elongation Factor SPT5 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SUPT5H 20924 O55201
SUPT5H 6829 O00267
Rat SUPT5H SUPT5H 308472  
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Top Transcription Elongation Factor SPT5 Proteins at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SUPT5H Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Transcription Elongation Factor SPT5 (SUPT5H) Interaction Partners

Fruit Fly (Drosophila melanogaster) Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. Spt5 interacts both physically and genetically with the Polycomb (show CBX2 Proteins) Group (PcG) protein Pleiohomeotic (Pho)

  2. We show that SPT5 interacts directly with MSL1 in vitro and is required downstream of MSL complex recruitment, providing the first mechanistic data corroborating the elongation model of dosage compensation.

  3. Spt5 acts both positively and negatively on transcription in vivo during heat shock induction.

Arabidopsis thaliana Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. SPT5-like protein emerged in plants as a facultative RNA polymerase elongation factor (show TSFM Proteins).[SPT5]

Mouse (Murine) Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.

  2. our findings indicate that Spt4 (show SUPT4H1 Proteins) and Spt5 have essential functions in the DNA repair phase of immunoglobulin class switch recombination.

  3. Study reports that Spt5, a factor normally associated with stalled or paused Pol II, is required for class switch recombination.

Zebrafish Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. the positive function of Foggy/Spt5 is required for gata1 (show GATA1 Proteins) expression during zebrafish embryonic hematopoiesis.

  2. RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5

  3. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo.

  4. spt 5-dependent transcript elongation is required cell-autonomously for a complex cell migration

  5. Spt5 as a dual regulator of transcription elongation in vivo; a small but diverse set of target genes critically dependent on Spt5 during development.

Human Transcription Elongation Factor SPT5 (SUPT5H) interaction partners

  1. A transcription-independent effect of tumor necrosis factor alpha (show TNF Proteins) on RNA splicing, mediated by Spt5.

  2. SPT5 contributes to the up-regulation of hTERT expression and colonic tumor development.

  3. Data indicate that the Plus3 domain of the Rtf1 (show RTF1 Proteins) subunit mediates Paf1C recruitment to genes by binding a repeating domain within the phosphorylated elongation factor (show TSFM Proteins) Spt5.

  4. DSIF Is Selectively Required for mRNA Splicing and Export of NF-kappaB (show NFKB1 Proteins) Target Genes.

  5. RNA polymerase II elongation repression is critically dependent on the C-terminus of Spt5

  6. crystal structure of hSpt4 (show SUPT4H1 Proteins) in complex with the dimerization region of hSpt5

  7. phosphorylated by P-TEFb (show CCNT1 Proteins) kinase during HIV-1 transcription in Tat (show TAT Proteins)/TAR (show RBM8A Proteins) dependent manner

  8. hSpt5 function in transcription regulation and mRNA capping is essential for a subset of cellular and viral genes and may not be required for global gene expression.

  9. evolutionarily conserved repetitive heptapeptide motif (consensus = G-S-R/Q-T-P) in the C-terminal region of hSpt5, like the C-terminal domain of RNA Pol II, is highly phosphorylated by P-TEFb (show CCNT1 Proteins)

  10. Upon induction of NF-kappaB (show NFKB1 Proteins), a subset of target genes is regulated differentially by either P-TEFb (show CCNT1 Proteins) or DSIF.[P-TEFb (show CCNT1 Proteins), DSIF]

Transcription Elongation Factor SPT5 (SUPT5H) Protein Profile

Protein Summary

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Gene names and symbols associated with SUPT5H

  • CG7626 gene product from transcript CG7626-RA (Spt5)
  • transcription elongation factor SPT5 (Spt5)
  • transcription elongation factor Spt5 (AT2G34210)
  • transcription elongation factor Spt5 (spt5)
  • transcription elongation factor spt5 (MGYG_08422)
  • transcription elongation factor spt5 (TERG_05483)
  • transcription elongation factor SPT5 (PGTG_18458)
  • Protein SPT-5 (spt-5)
  • similar to S. cerevisiae SPT5 (YML010W) RNA Pol II transcription elongation factor (SPT5)
  • suppressor of Ty 5 (Supt5)
  • suppressor of Ty 5 homolog (supt5h)
  • suppressor of Ty 5 homolog (S. cerevisiae) (supt5h)
  • suppressor of Ty 5 homolog (S. cerevisiae) (SUPT5H)
  • suppressor of Ty 5 homolog (S. cerevisiae) (Supt5h)
  • AL033283 protein
  • AL033321 protein
  • AU019549 protein
  • CG7626 protein
  • dDSIF protein
  • Dmel\\CG7626 protein
  • DSIF protein
  • dSpt5 protein
  • etID10129.15 protein
  • etID37101.15 protein
  • F13P17.5 protein
  • F13P17_5 protein
  • fb37g01 protein
  • fb95e05 protein
  • fog protein
  • foggy protein
  • Spt5 protein
  • SPT5H protein
  • Supt5h protein
  • Tat-CT1 protein
  • wu:fb37g01 protein
  • wu:fb95e05 protein
  • wu:fc10f02 protein

Protein level used designations for SUPT5H

CG7626-PA , Spt5-PA , transcription elongation factor SPT5 , transcription elongation factor Spt5 , transcription elongation factor spt5 , potential RNA Pol II transcription elongation factor , DRB sensitivity-inducing factor large subunit , DSIF large subunit , suppressor of Ty 5 homolog , protein foggy , transcription elongation regulator foggy , DRB sensitivity-inducing factor 160 kDa subunit , DSIF p160 , Tat-cotransactivator 1 protein , hSPT5

GENE ID SPECIES
53442 Drosophila melanogaster
413814 Apis mellifera
817982 Arabidopsis thaliana
2541916 Schizosaccharomyces pombe 972h-
10024747 Arthroderma gypseum CBS 118893
10372474 Trichophyton rubrum CBS 118892
10537737 Puccinia graminis f. sp. tritici CRL 75-36-700-3
178143 Caenorhabditis elegans
3635993 Candida albicans SC5314
20924 Mus musculus
733281 Xenopus laevis
64275 Danio rerio
426493 Gallus gallus
6829 Homo sapiens
476462 Canis lupus familiaris
519808 Bos taurus
308472 Rattus norvegicus
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