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Transcription Factor 21 Proteins (TCF21)

TCF21 encodes a transcription factor of the basic helix-loop-helix family. Additionally we are shipping TCF21 Antibodies (48) and TCF21 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TCF21 79585 P57737
TCF21 21412 O35437
Rat TCF21 TCF21 252856  
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Top TCF21 Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TCF21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Transcription Factor 21 (TCF21) Interaction Partners

Human Transcription Factor 21 (TCF21) interaction partners

  1. These findings show that POD-1/TCF21 regulates SF-1 (show NR5A1 Proteins) and LRH-1 (show NR5A2 Proteins) by distinct mechanisms, contributing to the understanding of POD-1 involvement and its mechanisms of action in adrenal and liver tumorigenesis.

  2. TCF21 may function as a tumor suppressor gene, which is downregulated through promoter hypermethylation in CRC (show CALR Proteins) development.

  3. The presence of significant hypermethylation of TCF21 supports the hypothesis that hypermethylation of TCF21 and/or decreased TARID expression lies within the pathogenic pathway of most CCSKs.

  4. our data provided the first evidence that TCF21 mRNA is significantly downregulated in breast cancer cell lines and tissues and regulates breast cancer cell proliferation and EMT (show ITK Proteins).

  5. Separate enrichment analyses found over-representation of TCF21 target genes among CAD associated genes, and linkage disequilibrium between TCF21 peak variation and that found in GWAS loci consistent with the hypothesis that TCF21 may affect disease risk

  6. Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function

  7. TCF21 could inhibit the proliferation and migration of SMMC-7721 hepatocellular carcinoma cells and promote its apoptosis

  8. Low TCF21 expression is associated with gastric cancer.

  9. TCF21 inhibits the proliferation and migration and facilitates early apoptosis of A549 cells.

  10. these data suggest that miR (show MLXIP Proteins)-224 interaction with the TCF21 transcript contributes to allelic imbalance of this gene, thus partly explaining the genetic risk for coronary heart disease associated at 6q23.2

Mouse (Murine) Transcription Factor 21 (TCF21) interaction partners

  1. During normal heart development, spatio-temporal differences in contribution of WT-1 (show WT1 Proteins) and Tcf21-LacZ (show GLB1 Proteins) + cells to right versus left ventricular myocardium occur parallel to myocardial thickening.

  2. TCF21 may have a role regulating the differentiation state of SMC (show DYM Proteins) precursor cells that migrate into vascular lesions and contribute to the fibrous cap and more broadly, in view of the association of this gene with human Coronary Artery Disease

  3. Our results demonstrate a critical role for Tcf21 in the differentiation and maintenance of podocytes.

  4. Data indicate that loss of Pod1/Tcf21 leads to epicardial blistering, increased smooth muscle cell differentiation on the surface of the heart, and a paucity of interstitial fibroblasts, with neonatal lethality.

  5. The majority of Tcf21-expressing epicardial cells are committed to the cardiac fibroblast lineage prior to initiation of epicardial epithelial-to-mesenchymal transition.

  6. Data show that correct levels of expression of Myf5 (show MYF5 Proteins) and MyoD (show MYOD1 Proteins) during mouse craniofacial development result from activation by musculin (show MSC Proteins) and TCF21 through direct binding to specific enhancers.

  7. epicardin/capsulin/Pod-1 functions as a negative regulator of differentiation of myoblasts through transcription in cell growth arrest and lineage-specific differentiation

  8. findings identify MyoR (show MSC Proteins) and capsulin as unique transcription factors for the development of specific head muscles

  9. cell autonomous and non-cell autonomous roles for Pod1 in the differentiation of specific renal cell lineages that include peritubular interstitial cells and pericytes.

  10. Pod-1, which controls androgen receptor (show AR Proteins) transcription and function, may play an important role in the development and function of the testis.

Xenopus laevis Transcription Factor 21 (TCF21) interaction partners

  1. Tcf21 functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium

  2. Distribution of a basic helix-loop-helix transcription factor (show HEY1 Proteins) expressed very early in the development of the pronephric glomus is described.

Zebrafish Transcription Factor 21 (TCF21) interaction partners

  1. Capsulin has an essential role in zebrafish craniofacial myogenesis.

  2. Upstream sequences of the transcription factor gene tcf21 activate robust, epicardium-specific expression throughout development and regeneration.

  3. Endogenous Capsulin was distributed mainly in the epicardial cells of zebrafish.

TCF21 Protein Profile

Protein Summary

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with TCF21

  • transcription factor 21 (TCF21)
  • transcription factor 21 (tcf21)
  • transcription factor 21 (Tcf21)
  • Transcription factor 21 (tcf21)
  • transcription factor 21 (LOC100346722)
  • coronin 7 (CORO7)
  • 0610011B16Rik protein
  • ACYPI002601 protein
  • bHLHa23 protein
  • Capsulin protein
  • CRN7 protein
  • epc protein
  • Epicardin protein
  • Msf-1 protein
  • Pod-1 protein
  • Pod1 protein
  • tcf21 protein
  • zgc:123313 protein

Protein level used designations for TCF21

transcription factor 21 , TCF-21 , capsulin , epicardin , pod 1 , podocyte-expressed 1 , Transcription factor 21 , 70 kDa WD repeat tumor rejection antigen homolog , coronin-7 , class A basic helix-loop-helix protein 23 , pod-1 , Pod 1 , Podocyte-expressed 1 , MyoRa2

463151 Pan troglodytes
707680 Macaca mulatta
100126209 Xenopus (Silurana) tropicalis
100161377 Acyrthosiphon pisum
100195288 Salmo salar
100303487 Saccoglossus kowalevskii
100346722 Oryctolagus cuniculus
79585 Homo sapiens
421697 Gallus gallus
6943 Homo sapiens
483993 Canis lupus familiaris
510873 Bos taurus
21412 Mus musculus
252856 Rattus norvegicus
444386 Xenopus laevis
558148 Danio rerio
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