Transforming Growth Factor, beta-Induced, 68kDa Proteins (TGFBI)

TGFBI encodes an RGD-containing protein that binds to type I, II and IV collagens. Additionally we are shipping Transforming Growth Factor, beta-Induced, 68kDa Antibodies (120) and Transforming Growth Factor, beta-Induced, 68kDa Kits (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGFBI 7045 Q15582
TGFBI 21810 P82198
Rat TGFBI TGFBI 116487  
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Top Transforming Growth Factor, beta-Induced, 68kDa Proteins at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$656.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$730.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 20 to 21 Days
$382.80
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 15 to 19 Days
$242.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,134.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 12 Days
$257.60
Details

TGFBI Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,
,

Top referenced Transforming Growth Factor, beta-Induced, 68kDa Proteins

  1. Human TGFBI Protein expressed in Human Cells - ABIN2003076 : Andersen, Karring, Møller-Pedersen, Valnickova, Thøgersen, Hedegaard, Kristensen, Klintworth, Enghild: Purification and structural characterization of transforming growth factor beta induced protein (TGFBIp) from porcine and human corneas. in Biochemistry 2004 (PubMed)
    Show all 6 references for 2003076

  2. Human TGFBI Protein expressed in Escherichia coli (E. coli) - ABIN666732 : Billings, Whitbeck, Adams, Abrams, Cohen, Engelsberg, Howard, Rosenbloom: The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for 666732

More Proteins for Transforming Growth Factor, beta-Induced, 68kDa (TGFBI) Interaction Partners

Human Transforming Growth Factor, beta-Induced, 68kDa (TGFBI) interaction partners

  1. TGFBI and periostin (show POSTN Proteins) act similarly in the heart in affecting fibrosis and disease responsiveness.

  2. The p.(Val113Ile) mutation results in an alteration of the atypical LCD phenotype associated with the p.(Leu558Pro) mutation. This represents only the second report of the alteration of the phenotype of a TGFBI dystrophy by a second, non-homozygous pathogenic mutation, and thus provides insight into the phenotype-genotype correlation of the TGFBI dystrophies.

  3. Our findings demonstrate that granular corneal dystrophy type 1 may present with a vortex pattern of anterior stromal deposits. Although this pattern of dystrophic deposits is not recognized by clinicians as a typical phenotype of GCD1, it is consistent with the production of the majority of the TGFBI protein by the corneal epithelium.

  4. The right cornea showed a higher number of lattice lines than the left cornea. Molecular analysis involving bidirectional complete sequencing demonstrated a novel T621P mutation in exon 14 of TGFBI.

  5. ig-h3, Peroxiredoxin-2 (show PRDX2 Proteins), and NRF2 (show GABPA Proteins) have roles in cervical carcinogenesis

  6. LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing TGFBI protein.

  7. High TGFBI expression in Esophageal squamous cell carcinoma is associated with hematogenous recurrence.

  8. We observed that knockdown of Cul4A was associated with increased sensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells.

  9. TGFBIp expression is positively regulated by TGF-beta1 (show TGFB1 Proteins) in corneal fibroblasts, whereas TGF-beta1 (show TGFB1 Proteins)-induced miR (show MLXIP Proteins)-21 and miR (show MLXIP Proteins)-181a negatively regulate TGFBIp expression.

  10. Data suggest that periostin and TGFBI (transforming growth factor-beta induced protein) can be considered paralogs in some ways: structural homology, phylogeny, and functions in extracellular matrix formation/cell adhesion/cellular immunity. [REVIEW]

Mouse (Murine) Transforming Growth Factor, beta-Induced, 68kDa (TGFBI) interaction partners

  1. Data suggest that big-h3 protein (BIGH3 (show TGFB1 Proteins)) acts as a tumor suppressor in the retina.

  2. TGF-beta (show TGFB1 Proteins)-induced matricellular protein-null lungs displayed diminished elastic recoil and gas exchange efficiency

  3. the data suggest a model by which cytokine-induced Myt3 suppression leads to Tgfbi de-repression and subsequently to impaired islet-cell migration, revealing a novel role for Myt3 in regulating islet-cell migration.

  4. Studies reveal that growth hormone (GH (show GH1 Proteins))increases TGFBI (show TGFB1 Proteins) expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN.

  5. Tgfbi deficiency is associated with the degradation of cartilage matrix

  6. The results support a novel inflammatory pathway for diabetic retinopathy. This pathway is initiated by TGFbeta released from macrophages, which promotes synthesis and release of BIGH3 protein by REC and REC apoptosis.

  7. TGFBI is a potential risk gene for human diabetes.

  8. High blood TGFBIp levels were observed in cecal ligation and puncture (CLP)-induced septic mice. The absence of the TGFBIp gene in mice attenuated CLP-induced sepsis.

  9. Collectively, our findings indicate that betaig-h3 (show TGFB1 Proteins) promotes the fibrogenic influence of TGFbeta (show TGFB1 Proteins) signaling, neutralizing the prochondrogenic influence of the hypoxic-inducible factor 1 activated by the microenvironment of limb mesenchymal aggregates.

  10. the observed effect of TGFBI on bone mass and bone size was largely caused by the effect of TGFBI on periosteal bone formation

Zebrafish Transforming Growth Factor, beta-Induced, 68kDa (TGFBI) interaction partners

  1. This study shows that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins.

  2. Results describe the distribution of TGFBI in the developing skeletal muscle of zebrafish embryos, and use antisense morpholino oligonucleotides to investigate the function of the endogenous protein.

Arabidopsis thaliana Transforming Growth Factor, beta-Induced, 68kDa (TGFBI) interaction partners

  1. downregulation of CSD2 (show TGFB1 Proteins) by the heat-inducible miR398 is required for thermotolerance in Arabidopsis.

  2. Data indicate that in the MKK5 (show MAP2K5 Proteins)-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (show TGFB1 Proteins) as well as the activation of MKK5 (show MAP2K5 Proteins) activity were completely arrested.

  3. Data indicate that transgenic plants expressing miR398-resistant forms of CSD1, CSD2 (show TGFB1 Proteins) and CCS (show CCS Proteins) under the control of their native promoters are more sensitive to heat stress.

  4. miR398 links expression of the three major chloroplast copper proteins, plastocyanin, CCS1 and Csd2 (show TGFB1 Proteins), to copper availability.

  5. CSD2 (show TGFB1 Proteins) expression is fine-tuned by miR398-directed mRNA cleavage.

  6. Results show that CSD1, but not CSD2 (show TGFB1 Proteins), mRNA levels were negatively correlated with miR398 levels during ozone, salinity and biotic stress.

Transforming Growth Factor, beta-Induced, 68kDa (TGFBI) Protein Profile

Protein Summary

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.

Gene names and symbols associated with TGFBI

  • transforming growth factor, beta-induced, 68kDa (TGFBI)
  • transforming growth factor, beta induced (Tgfbi)
  • transforming growth factor, beta-induced, 68kDa (Tgfbi)
  • transforming growth factor, beta-induced (tgfbi)
  • copper/zinc superoxide dismutase 2 (CSD2)
  • 68kDa protein
  • AI181842 protein
  • AI747162 protein
  • Beta-ig protein
  • Big-h3 protein
  • BIGH3 protein
  • CDB1 protein
  • CDG2 protein
  • CDGG1 protein
  • COPPER/ZINC SUPEROXIDE DISMUTASE protein
  • copper/zinc superoxide dismutase 2 protein
  • CSD protein
  • CSD1 protein
  • CSD2 protein
  • CSD3 protein
  • CZSOD2 protein
  • EBMD protein
  • F24D13.2 protein
  • F24D13_2 protein
  • hm:zeh0933 protein
  • LCD1 protein
  • MP70 protein
  • MP78 protein
  • wu:fa13f05 protein
  • zgc:110495 protein

Protein level used designations for TGFBI

RGD-CAP , transforming growth factor-beta-induced protein ig-h3 , RGD-containing collagen-associated protein , beta ig-h3 , kerato-epithelin , transforming growth factor, beta induced, 68 kDa , transforming growth factor, beta induced , etID38199.14 , Transforming growth factor-beta-induced protein ig-h3 , transforming growth factor induced protein

GENE ID SPECIES
395897 Gallus gallus
7045 Homo sapiens
21810 Mus musculus
116487 Rattus norvegicus
100717287 Cavia porcellus
100519300 Sus scrofa
539596 Bos taurus
321421 Danio rerio
817365 Arabidopsis thaliana
100009230 Oryctolagus cuniculus
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