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Transgelin Proteins (TAGLN)

The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Additionally we are shipping Transgelin Antibodies (120) and Transgelin Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAGLN 6876 Q01995
TAGLN 21345 P37804
TAGLN 25123 P31232
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Top Transgelin Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Transgelin (TAGLN) (AA 2-201), (full length) protein (GST tag) 1 mg Log in to see 56 to 66 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,482.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,486.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,486.00
Details
HOST_Escherichia coli (E. coli) REACT_Escherichia coli His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details

TAGLN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Transgelin Proteins

  1. Human Transgelin Protein expressed in Escherichia coli (E. coli) - ABIN667026 : Kobayashi, Kubota, Hidaka: Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog. in Biochemical and biophysical research communications 1994 (PubMed)
    Show all 2 references for ABIN667026

More Proteins for Transgelin (TAGLN) Interaction Partners

Human Transgelin (TAGLN) interaction partners

  1. Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis

  2. activated AKT (show AKT1 Proteins) and JNK (show MAPK8 Proteins) signaling pathways promote the overexpression of transgelin

  3. Cofilin-1 (show CFL1 Proteins) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma

  4. Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.

  5. SM22alpha is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha (show NFKBIA Proteins)-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  6. EZH2 (show EZH2 Proteins) regulates the chromatin structure at the TAGLN promoter through tri (show VANGL2 Proteins)-methylation of H3K27, acting as an epigenetic integrator of IL-1beta (show IL1B Proteins) and TGFbeta2 signaling.

  7. Transgelin may be an excellent diagnostic marker of Triple negative tumors and could be useful in stratification of patients

  8. Results indicate that miR (show MLXIP Proteins)-144 may regulate osteosarcoma cell proliferation and invasion by downregulating its target gene, transgelin protein (TAGLN), suggesting that miR (show MLXIP Proteins)-144 may be a potential therapeutic target for the treatment of osteosarcoma.

  9. TAGLN was highly expressed in NF1 (show NF1 Proteins)-deficient malignant peripheral nerve sheath tumors compared to NF1 (show NF1 Proteins)-deficient plexiform neurofibromas. Upregulation was caused by increased transcriptional expression. The TAGLN gene was hypomethylated in the MPNST cells.

  10. our data suggest that TAGLN may be a viable therapeutic target and a potential biomarker for predicting the prognosis of patients with lung adenocarcinoma.

Mouse (Murine) Transgelin (TAGLN) interaction partners

  1. SM22alpha is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha (show NFKBIA Proteins)-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  2. SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling.

  3. TRAF6 (show TRAF6 Proteins)-SM22alpha-G6PD (show G6PD Proteins) pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.

  4. Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.

  5. SM22alpha-regulated molecular pathways contribute to vascular pathology.

  6. Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl (show TNFSF11 Proteins) ( tg ) mice

  7. Data show that formation of a Krupple-like factor KLF4 (show KLF4 Proteins), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 Proteins)) multiprotein complex dependent on the SM22alpha G/C Repressor element.

  8. Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.

  9. We conclude that the de novo expression of SM22alpha in glomerular epithelial cells affects the course of crescentic glomerulonephritis.

  10. critical role for the Tsc1 (show TSC1 Proteins)/Tsc2-mTORC1-S6K (show RPS6KB1 Proteins) axis in the normal development of cardiovascular tissue

Transgelin (TAGLN) Protein Profile

Protein Summary

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Transgelin Proteins (TAGLN)

  • transgelin (tagln)
  • transgelin (LOC732906)
  • transgelin (TAGLN)
  • transgelin (tagl)
  • transgelin (Tagln)
  • MGC68550 protein
  • MGC107855 protein
  • Sm22 protein
  • SM22A protein
  • SMCC protein
  • TAGLN1 protein
  • WS3-10 protein
  • Ws310 protein
  • zgc:153186 protein

Protein level used designations for Transgelin Proteins (TAGLN)

transgelin , putative transgelin , 22 kDa actin-binding protein , SM22-alpha , smooth muscle protein 22-alpha , transgelin variant 2 , SM22 , Sm22alpha , actin-associated protein p27 , smooth muscle 22 protein , 25 kDa F-actin-binding protein , sm22 , sm22alpha-b

GENE ID SPECIES
399014 Xenopus laevis
594967 Xenopus (Silurana) tropicalis
732906 Bombyx mori
100189993 Taeniopygia guttata
100528947 Ictalurus punctatus
6876 Homo sapiens
100009332 Oryctolagus cuniculus
21345 Mus musculus
25123 Rattus norvegicus
479424 Canis lupus familiaris
513463 Bos taurus
396490 Gallus gallus
397021 Sus scrofa
751758 Danio rerio
100728822 Cavia porcellus
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