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The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Additionally we are shipping Transgelin Antibodies (182) and Transgelin Kits (19) and many more products for this protein.
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Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.
transgelin (TAGLN), a transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells
regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 (show IL8 Proteins) uptake
Serum concentrations of CK-18 fragments and transgelin-2 correlate with the severity of NAFLD, but not with obesity.
Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis
activated AKT (show AKT1 Proteins) and JNK (show MAPK8 Proteins) signaling pathways promote the overexpression of transgelin
Cofilin-1 (show CFL1 Proteins) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma
Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.
SM22alpha is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha (show NFKBIA Proteins)-NF-kappaB (show NFKB1 Proteins) signaling cascades.
EZH2 (show EZH2 Proteins) regulates the chromatin structure at the TAGLN promoter through tri (show VANGL2 Proteins)-methylation of H3K27, acting as an epigenetic integrator of IL-1beta (show IL1B Proteins) and TGFbeta2 signaling.
Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.
SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling.
TRAF6 (show TRAF6 Proteins)-SM22alpha-G6PD (show G6PD Proteins) pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.
Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.
SM22alpha-regulated molecular pathways contribute to vascular pathology.
Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl (show TNFSF11 Proteins) ( tg ) mice
Data show that formation of a Krupple-like factor KLF4 (show KLF4 Proteins), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 Proteins)) multiprotein complex dependent on the SM22alpha G/C Repressor element.
Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.
, putative transgelin
, 22 kDa actin-binding protein
, smooth muscle protein 22-alpha
, transgelin variant 2
, actin-associated protein p27
, smooth muscle 22 protein
, 25 kDa F-actin-binding protein