Transgelin Proteins (TAGLN)

The protein encoded by TAGLN is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Additionally we are shipping Transgelin Antibodies (182) and Transgelin Kits (19) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TAGLN 6876 Q01995
TAGLN 21345 P37804
TAGLN 25123 P31232
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Top Transgelin Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$286.00
Details
HOST_Escherichia coli (E. coli) Human GST tag Transgelin (TAGLN) (AA 2-201), (full length) protein (GST tag) 1 mg Log in to see 60 to 71 Days
$1,842.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$2,482.33
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,486.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,486.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 2 to 3 Days
$2,524.50
Details

TAGLN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Transgelin (TAGLN) Interaction Partners

Human Transgelin (TAGLN) interaction partners

  1. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.

  2. transgelin (TAGLN), a transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-inducible gene, was identified as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells

  3. regulates vasculogenic mimicry in breast cancer cells by enhancing interleukin-8 (show IL8 Proteins) uptake

  4. Serum concentrations of CK-18 fragments and transgelin-2 correlate with the severity of NAFLD, but not with obesity.

  5. Increases or decreases in transgelin levels have reciprocal effects on tumor cell behavior, with higher expression promoting metastasis

  6. activated AKT (show AKT1 Proteins) and JNK (show MAPK8 Proteins) signaling pathways promote the overexpression of transgelin

  7. Cofilin-1 (show CFL1 Proteins) and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma

  8. Both tissue and salivary transgelin mRNA were closely correlated with various important clinicopathological parameters and were independent prognosis factors for oral squamous cell carcinoma.

  9. SM22alpha is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha (show NFKBIA Proteins)-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  10. EZH2 (show EZH2 Proteins) regulates the chromatin structure at the TAGLN promoter through tri (show VANGL2 Proteins)-methylation of H3K27, acting as an epigenetic integrator of IL-1beta (show IL1B Proteins) and TGFbeta2 signaling.

Mouse (Murine) Transgelin (TAGLN) interaction partners

  1. Data (including data from studies using cells cultured from transgenic/knockout mice) suggest that expression and degradation of transgelin in myofibroblasts and keratinocytes are regulated by mechanical tension in cytoskeleton produced by myosin II motor in response to stiffness of culture matrix/extracellular matrix.

  2. Targeted elimination of TGFbetaR2 in TAGLN(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.

  3. SM22alpha is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha (show NFKBIA Proteins)-NF-kappaB (show NFKB1 Proteins) signaling cascades.

  4. SM22alpha promotes ubiquitination and degradation of MKP3. SM22alpha facilitates AngII-induced contraction by maintenance of ERK1/2 signaling.

  5. TRAF6 (show TRAF6 Proteins)-SM22alpha-G6PD (show G6PD Proteins) pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability.

  6. Absent/lower SM22 alpha levels favor an increase in parietal epithelial cell transition cells and PECs expressing a progenitor marker, and a lower epithelial mesenchymal transformation rate versus SM22alpha+/+mice, where SM22 levels are increased in PECs.

  7. SM22alpha-regulated molecular pathways contribute to vascular pathology.

  8. Histological analysis did not reveal calcium deposits in the aortic roots of SM22alpha-Rankl (show TNFSF11 Proteins) ( tg ) mice

  9. Data show that formation of a Krupple-like factor KLF4 (show KLF4 Proteins), pELK-1, and histone de-acetylase 2 (HDAC2 (show HDAC2 Proteins)) multiprotein complex dependent on the SM22alpha G/C Repressor element.

  10. Data suggest that SM22alpha expression in renal tissues might be a hallmark of kidney diseases.

Transgelin (TAGLN) Protein Profile

Protein Summary

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Transgelin Proteins (TAGLN)

  • transgelin (tagln)
  • transgelin (LOC732906)
  • transgelin (TAGLN)
  • transgelin (tagl)
  • transgelin (Tagln)
  • MGC68550 protein
  • MGC107855 protein
  • Sm22 protein
  • SM22A protein
  • SMCC protein
  • TAGLN1 protein
  • WS3-10 protein
  • Ws310 protein
  • zgc:153186 protein

Protein level used designations for Transgelin Proteins (TAGLN)

transgelin , putative transgelin , 22 kDa actin-binding protein , SM22-alpha , smooth muscle protein 22-alpha , transgelin variant 2 , SM22 , Sm22alpha , actin-associated protein p27 , smooth muscle 22 protein , 25 kDa F-actin-binding protein , sm22 , sm22alpha-b

GENE ID SPECIES
399014 Xenopus laevis
594967 Xenopus (Silurana) tropicalis
732906 Bombyx mori
100189993 Taeniopygia guttata
100528947 Ictalurus punctatus
6876 Homo sapiens
100009332 Oryctolagus cuniculus
21345 Mus musculus
25123 Rattus norvegicus
479424 Canis lupus familiaris
513463 Bos taurus
396490 Gallus gallus
397021 Sus scrofa
751758 Danio rerio
100728822 Cavia porcellus
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