Transglutaminase 1, Keratinocyte Proteins (TGM1)

The protein encoded by TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. Additionally we are shipping TGM1 Antibodies (80) and TGM1 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TGM1 7051 P22735
TGM1 60335 P23606
TGM1 21816 Q9JLF6
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Top TGM1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$714.00
Details
Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
Escherichia coli (E. coli) Rabbit His tag,GST tag 100 μg Log in to see 15 to 18 Days
$768.00
Details
Escherichia coli (E. coli) Dog His tag,GST tag 100 μg Log in to see 15 to 18 Days
$771.00
Details
Wheat germ Human GST tag   10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$639.61
Details

TGM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

Top referenced TGM1 Proteins

  1. Human TGM1 Protein expressed in Wheat germ - ABIN1322632 : Yang, Chevolot, Géhin, Solassol, Mange, Souteyrand, Laurenceau: Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera. in Biosensors & bioelectronics 2012 (PubMed)

More Proteins for Transglutaminase 1, Keratinocyte (TGM1) Interaction Partners

Human Transglutaminase 1, Keratinocyte (TGM1) interaction partners

  1. We also reveal that TGM1 modulates lung epithelial junction protein expression, suggesting a potentially protective role for hypoxia-induced TGM1 in pulmonary disease.

  2. A novel TGM1 variant c.1085T>G was found in an Emirati family. The mutation causes a nonsynonymous protein change (p.Leu362Arg) that affects a highly conserved residue in the catalytic core domain of the calcium-dependent transglutaminase-1.

  3. that the up-regulation of molecular signatures for antimicrobial and innate defense responses is characteristic of skin with a transglutaminase 1 deficiency.

  4. Seven of 10 probands with a compound heterozygous TGM1 genotype had a mutation at either arginine 307 or 315, providing evidence that mutations at these sites are temperature sensitive and highlighting the importance of these residues in the pathogenesis of bathing suit ichthyosis (show LBR Proteins)

  5. The results strongly supported the participation of TGM1 in the regulation of gastric cancer development. The authors found evidence that the mechanism of action of TGM1 in regulating gastric cancer cell might involve the Wnt (show WNT2 Proteins) signaling pathway, as loss of TGM1 expression in gastric cancer cells led to a significant suppression of Wnt (show WNT2 Proteins) signaling activities.

  6. we identified three novel mutations and one reported mutation in the TGM1 and ABCA12 genes, respectively, in affected siblings of five Saudi unrelated families.

  7. Data indicate a decrease in transglutaminases TG1 and TG3 transcripts by about 70% in foreskins from patients with balanitis xerotica obliterans (BXO) BXO in comparison with patients without BXO and an increase in transglutaminase TG2 (show TGM2 Proteins) mRNA levels by 2.9 fold.

  8. In summary, we have identified three novel sequence variants, one in TGM1 and two in ALOXE3 (show ALOXE3 Proteins), in three consanguineous families segregating lamellar ichthyosis (show LBR Proteins) and congenital ichthyosiform erythroderma types of autosomal recessive congenital ichthyosis (show LBR Proteins).

  9. Our results thus indicated that the TGM1 mutation affects the formation of corni fi ed cell envelope by multiple mechanisms and leads to an almost identical clinical phenotype of generalized erythema and scales.

  10. Two siblings with autosomal recessive congenital ichthyosis (show LBR Proteins), were found to carry a novel aetiological TGM1 mutation that leads to the synthesis of multiple abnormal transcripts.

Cow (Bovine) Transglutaminase 1, Keratinocyte (TGM1) interaction partners

  1. Linkage analysis excluded TGM1 as the cause for ichthyosis (show LBR Proteins) phenotype.

Mouse (Murine) Transglutaminase 1, Keratinocyte (TGM1) interaction partners

  1. We also reveal that TGM1 modulates lung epithelial junction protein expression, suggesting a potentially protective role for hypoxia-induced TGM1 in pulmonary disease.

  2. Characterization of TGM2 (show TGM2 Proteins) and TGM1-TGM2 (show TGM2 Proteins) double knock-out mouse epidermis showed that unlike TGM2 (show TGM2 Proteins), TGM1 is indispensable for skin formation.

  3. that the up-regulation of molecular signatures for antimicrobial and innate defense responses is characteristic of skin with a transglutaminase 1 deficiency.

  4. This study investigated the in situ activities of transglutaminase-1 (skin-type) and transglutaminase-2 (show TGM2 Proteins) (tissue-type) using whole mouse sections of various embryonic developmental stages and neonates.

  5. The R142C mutation of transglutaminase 1 reduces the enzyme stability which is indispensable for development of the stratum corneum and skin barrier function and for postnatal survival of mice.

  6. Molecular deletion of transglutaminase 2 (show TGM2 Proteins) alone is insufficient to protect Mus (show TRPV6 Proteins) musculus neurons from oxidative death, but inhibition of transglutaminase 1 and 2 is neuroprotective.

  7. These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 (show TGM4 Proteins) are expressed in vascular tissues

  8. Mouse models are used to study the role of tissue transglutaminase (tTG (show TGM2 Proteins))in Huntington's disease; its critical that the level of expression in mouse forebrain be determined. tTG (show TGM2 Proteins) contributes to the majority of transglutaminase activity in mouse forebrain.

  9. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

  10. Tissue-specific stabilization of the cortical actin filament network by intracellular TGase1 activity may play a role in controlling barrier properties of endothelial monolayers

TGM1 Protein Profile

Protein Summary

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).

Gene names and symbols associated with TGM1

  • transglutaminase 1 (TGM1)
  • transglutaminase 1 like 4 (tgm1l4)
  • transglutaminase 1 (Tgm1)
  • transglutaminase 1, K polypeptide (Tgm1)
  • 2310004J08Rik protein
  • ARCI1 protein
  • fa12g12 protein
  • ICR2 protein
  • KTG protein
  • LI protein
  • LI1 protein
  • TGASE protein
  • Tgase1 protein
  • TGK protein
  • TGM1 protein
  • wu:fa12g12 protein
  • zgc:112355 protein

Protein level used designations for TGM1

transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) , TG1-62 , transglutaminase 1 , K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase , TG(K) , TGase K , TGase-1 , epidermal TGase , protein-glutamine gamma-glutamyltransferase K , transglutaminase 1 isoform , transglutaminase K , transglutaminase, keratinocyte , transglutaminase-1 , TGK , transglutaminase 1, K polypeptide , Protein-glutamine gamma-glutamyltransferase K , tranglutaminase 1 , K polypeptide , TG K , TGase 1 , protein-glutamine-gamma-glutamyltransferase , transglutaminase type 1

GENE ID SPECIES
452814 Pan troglodytes
555962 Danio rerio
7051 Homo sapiens
60335 Rattus norvegicus
100724400 Cavia porcellus
100009118 Oryctolagus cuniculus
403630 Canis lupus familiaris
407997 Bos taurus
21816 Mus musculus
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