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The protein encoded by TRPM4 is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. Additionally we are shipping TRPM4 Kits (8) and TRPM4 Proteins (7) and many more products for this protein.
Showing 10 out of 84 products:
Human Polyclonal TRPM4 Primary Antibody for IHC, WB - ABIN351201
Xu, Moebius, Gill, Montell: Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 10 references for ABIN351201
Human Polyclonal TRPM4 Primary Antibody for EIA, WB - ABIN953385
Liu, El Zein, Kruse, Guinamard, Beckmann, Bozio, Kurtbay, Mégarbané, Ohmert, Blaysat, Villain, Pongs, Bouvagnet: Gain-of-function mutations in TRPM4 cause autosomal dominant isolated cardiac conduction disease. in Circulation. Cardiovascular genetics 2010
Show all 3 references for ABIN953385
Cow (Bovine) Polyclonal TRPM4 Primary Antibody for WB - ABIN2776221
Park, Hwang, Yarishkin, Seo, Kim, Yoo, Yi, Kim, Park, Ha, La, Kang, Han, Oh, Hong: TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel. in Biochemical and biophysical research communications 2008
Show all 2 references for ABIN2776221
Dog (Canine) Monoclonal TRPM4 Primary Antibody for IHC, WB - ABIN2452428
Becerra, Echeverría, Varela, Sarmiento, Armisén, Nuñez-Villena, Montecinos, Simon: Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death. in Cardiovascular research 2011
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A large pedigree diagnosed with progressive familial heart block type I was linked to a mutation of the TRPM4 ion channel.
Identify TRPM4 as a regulator of store operated calcium entry in prostate tumor cells, and demonstrate a role for TRPM4 in cancer cell migration.
TRPM4 channels regulate human detrusor smooth muscle excitability and contractility and are critical determinants of human urinary bladder function
TRPM4 protein expression is widely expressed in benign and cancerous prostate tissue
new insight into the ligand binding domains of the TRPM4 channel
Casein kinase 1 (show CSNK1A1 Antibodies) phosphorylates S839 and is responsible for the basolateral localization of TRPM4.
TRPM4 acts to maintain endothelial features and its loss promotes fibrotic conversion via TGF-beta (show TGFB1 Antibodies) production.
we demonstrate that the inhibition of TRPM4 activity alters cellular contractility in vivo, affecting cutaneous wound healing.
The PKC (show PRRT2 Antibodies)-dependent effect of GLP-1 (show GCG Antibodies) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (show TRPM5 Antibodies) channels by mobilization of intracellular Ca(2 (show CA2 Antibodies)+) from thapsigargin-sensitive Ca(2 (show CA2 Antibodies)+) stores
TRPM4 protein is a ROS (show ROS1 Antibodies)-modulated non-selective cationic channel that performs several cell functions, including regulating intracellular Ca(2 (show CA2 Antibodies)+) overload and Ca(2 (show CA2 Antibodies)+) oscillation
Disrupting the Trpm4 gene in mice specifically eliminates NMDAR (show GRIN1 Antibodies)-dependent LTP (show SCP2 Antibodies).
observations are consistent with a model in which TRPM4 is a regulator of calcium homeostasis in cardiomyocytes after AngII stimulation
The PKC (show PKC Antibodies)-dependent effect of GLP-1 (show GCG Antibodies) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (show TRPM5 Antibodies) channels by mobilization of intracellular Ca(2 (show CA2 Antibodies)+) from thapsigargin-sensitive Ca(2 (show CA2 Antibodies)+) stores
The function of TRPM4 in renal primary cilia is not yet known, but it is likely to influence the apical Ca(2 (show CA2 Antibodies)) dynamics of the cell
Deletion of the Trpm4 gene in mice improved survival and significantly enhanced beta-adrenergic cardiac reserve after inducing ischaemic heart failure.
TRPM4 has pleiotropic roles in the heart, including the regulation of conduction and cellular electrical activity which impact heart development.
The present study demonstrates that robust TRPM4-IR is localized specifically in the soma of Inner Auditory Hair Cells in the organ of Corti.
These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma (show YWHAG Antibodies) binding.
Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Results show that functional TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on the ventricular heart muscle.
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.
transient receptor potential cation channel, subfamily M, member 4
, calcium-activated non-selective cation channel 1
, long transient receptor potential channel 4
, transient receptor potential cation channel subfamily M member 4
, melastatin like 2 protein
, melastatin-like 2
, transient receptor potential ion channel melastatin subgroup member 4