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Transient Receptor Potential Cation Channel, Subfamily M, Member 4 Proteins (TRPM4)

The protein encoded by TRPM4 is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. Additionally we are shipping TRPM4 Antibodies (76) and TRPM4 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM4 54795 Q8TD43
Rat TRPM4 TRPM4 171143 Q9ESQ5
TRPM4 68667 Q7TN37
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Top TRPM4 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TRPM4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
,

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) Interaction Partners

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) interaction partners

  1. Identify TRPM4 as a regulator of store operated calcium entry in prostate tumor cells, and demonstrate a role for TRPM4 in cancer cell migration.

  2. TRPM4 channels regulate human detrusor smooth muscle excitability and contractility and are critical determinants of human urinary bladder function

  3. TRPM4 protein expression is widely expressed in benign and cancerous prostate tissue

  4. new insight into the ligand binding domains of the TRPM4 channel

  5. Casein kinase 1 (show CSNK1A1 Proteins) phosphorylates S839 and is responsible for the basolateral localization of TRPM4.

  6. TRPM4 acts to maintain endothelial features and its loss promotes fibrotic conversion via TGF-beta (show TGFB1 Proteins) production.

  7. we demonstrate that the inhibition of TRPM4 activity alters cellular contractility in vivo, affecting cutaneous wound healing.

  8. The PKC (show PRRT2 Proteins)-dependent effect of GLP-1 (show GCG Proteins) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (show TRPM5 Proteins) channels by mobilization of intracellular Ca(2 (show CA2 Proteins)+) from thapsigargin-sensitive Ca(2 (show CA2 Proteins)+) stores

  9. TRPM4 protein is a ROS (show ROS1 Proteins)-modulated non-selective cationic channel that performs several cell functions, including regulating intracellular Ca(2 (show CA2 Proteins)+) overload and Ca(2 (show CA2 Proteins)+) oscillation

  10. these data suggest an important role for the Sur1 (show ABCC8 Proteins)-Trpm4 channel in the pathophysiology of postischemic cell death

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) interaction partners

  1. observations are consistent with a model in which TRPM4 is a regulator of calcium homeostasis in cardiomyocytes after AngII stimulation

  2. The PKC-dependent effect of GLP-1 (show GCG Proteins) on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 (show TRPM5 Proteins) channels by mobilization of intracellular Ca(2 (show CA2 Proteins)+) from thapsigargin-sensitive Ca(2 (show CA2 Proteins)+) stores

  3. The function of TRPM4 in renal primary cilia is not yet known, but it is likely to influence the apical Ca(2 (show CA2 Proteins)) dynamics of the cell

  4. Deletion of the Trpm4 gene in mice improved survival and significantly enhanced beta-adrenergic cardiac reserve after inducing ischaemic heart failure.

  5. TRPM4 has pleiotropic roles in the heart, including the regulation of conduction and cellular electrical activity which impact heart development.

  6. The present study demonstrates that robust TRPM4-IR is localized specifically in the soma of Inner Auditory Hair Cells in the organ of Corti.

  7. These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma (show YWHAG Proteins) binding.

  8. Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4-deficient mice.

  9. Results show that functional TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on the ventricular heart muscle.

  10. N-Glycosylation is not required for surface expression, but complex N-glycosylation stabilizes Trpm4b surface expression.

TRPM4 Protein Profile

Protein Summary

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRPM4

  • transient receptor potential cation channel, subfamily M, member 4 (trpm4)
  • transient receptor potential cation channel, subfamily M, member 4 (TRPM4)
  • transient receptor potential cation channel, subfamily M, member 4 (Trpm4)
  • 1110030C19Rik protein
  • AW047689 protein
  • LTrpC-4 protein
  • LTRPC4 protein
  • Mls2s protein
  • PFHB1B protein
  • TRPM4 protein
  • TRPM4B protein

Protein level used designations for TRPM4

transient receptor potential cation channel, subfamily M, member 4 , LTrpC4 , calcium-activated non-selective cation channel 1 , hTRPM4 , long transient receptor potential channel 4 , melastatin-4 , transient receptor potential cation channel subfamily M member 4 , melastatin like 2 protein , melastatin-like 2 , transient receptor potential ion channel melastatin subgroup member 4

GENE ID SPECIES
398685 Xenopus laevis
456197 Pan troglodytes
54795 Homo sapiens
171143 Rattus norvegicus
484385 Canis lupus familiaris
100295930 Bos taurus
68667 Mus musculus
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