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The protein encoded by TRPM7 is both an ion channel and a serine/threonine protein kinase. Additionally we are shipping TRPM7 Proteins (5) and TRPM7 Kits (3) and many more products for this protein.
Showing 10 out of 168 products:
Dog (Canine) Polyclonal TRPM7 Primary Antibody for EIA, IHC (p) - ABIN782877
Sun, Jackson, Martin, Jansen, Teves, Cui, Kiyonaka, Mori, Jones, Forder, Golde, Orser, Macdonald, Tymianski: Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. in Nature neuroscience 2009
Show all 4 references for ABIN782877
Human Monoclonal TRPM7 Primary Antibody for ICC, IF - ABIN361775
Brauchi, Krapivinsky, Krapivinsky, Clapham: TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 references for ABIN361775
Human Polyclonal TRPM7 Primary Antibody for IHC (p), WB - ABIN392614
Gavenis, Schumacher, Schneider, Eisfeld, Mollenhauer, Schmidt-Rohlfing: Expression of ion channels of the TRP family in articular chondrocytes from osteoarthritic patients: changes between native and in vitro propagated chondrocytes. in Molecular and cellular biochemistry 2009
Show all 2 references for ABIN392614
Mouse (Murine) Polyclonal TRPM7 Primary Antibody for IHC (p), IHC - ABIN257037
Nadler, Hermosura, Inabe, Perraud, Zhu, Stokes, Kurosaki, Kinet, Penner, Scharenberg, Fleig: LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. in Nature 2001
Human Polyclonal TRPM7 Primary Antibody for EIA, IHC (p) - ABIN360499
Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001
tct may represent a novel as well as selective regulator of melanoblast development within the neural crest lineage.
Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
TRPM7 plays a role within sensory neurons in modulating neutrotransmitter release at central synapses, similar to the role proprosed for mammalian TRPM7 at peripheral synapses.
Trpm7 regulates exocrine pancreatic development via the Mg(2 (show MCOLN1 Antibodies)+)-sensitive Socs3a (show SOCS3 Antibodies) pathway.
This study showed that stanniocalcin 1 (stc1 (show STC1 Antibodies))modulates cation levels in trpm7 mutants and in the wild type; levels of cations are restored to normal in trpm7 mutants when stc1 (show STC1 Antibodies) activity is blocked.
Mutation in trpm7 leads to defective skeletogenesis and kidney stone formation.
Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.
an essential role for the ion channel TRPM7 and Mg(2 (show MCOLN1 Antibodies)+) in Rac (show AKT1 Antibodies)-dependent polarized cell movements during vertebrate gastrulation.
Data show that resistant cells express lower amounts of the transient receptor potential cation channel (show TRPV1 Antibodies) subfamily M TRPM6 (show TRPM6 Antibodies) and 7, both involved in magnesium transport.
TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice.
These results suggest that TRPM7 channel may play a critical role for zinc toxicity associated with stress.
The Different Roles of The Channel-Kinases TRPM6 (show TRPM6 Antibodies) and TRPM7
TRPM7 inhibition by siRNA caused an increase in adhesion relative to control, but a decrease to 80% of calcium response relative to non-targeting siRNA which confirms the important role of TRPM7 in mechanotransduction despite the increase in adhesion.
TRPM7 was involved in the regulation of hDPSC proliferation, migration and osteogenic differentiation and may play a role in the dental pulp repair process
Overexpression of TRPM7 expression is significantly associated with poor prognosis in patients with ovarian cancer.
TRPM7 expression closely associates with the migratory and metastatic properties of neuroblastoma (show ARHGEF16 Antibodies) cells in vitro and in vivo. TRPM7 controls a developmental transcriptional program involving the transcription factor SNAI2 (show SNAI2 Antibodies).
Study demonstrates that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells
These results identified a central role of TRPM7 in MSC (show MSC Antibodies) mechanical stimulation-induced osteogenesis
Inhibition of TRPM7 reduces calcium influx and accelerates the polarization of hippocampal neurons.
our results suggest the differential roles of TRPM7 in endochondral and intramembranous ossification.
TRPM7 kinase is a novel player in Angiotensin II induced hypertension and vascular and target organ damage.
Immature intercellular junctions in Trpm7 knock-out mice might lead to a disruption of barrier function resulting in inflammation and hypersensitive bladder afferent nerves that may affect voiding behavior in vivo
By inhibiting TRPM7 and ANO1 (show ANO1 Antibodies) via opioid receptor signaling pathways.
Abolishing TRPM7 kinase activity does not impair its channel activity and kinase activity is not essential for regulation of mammalian Mg(2 (show MCOLN1 Antibodies)+) homeostasis.
results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation.
C(60)HyFn administration significantly decreased serum levels of homocysteine and TRPM2 (show TRPM2 Antibodies) mRNA levels in HHcy + C(60)HyFn group. Whereas, HHcy-treatment and C(60)HyFn administration did not change the expression of TRPM7.
these data suggest that oxidative stress inhibits TRPM7 current under pathological conditions that accompany intracellular ATP depletion and free [Mg(2 (show MCOLN1 Antibodies)+)]i elevation.
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.
transient receptor potential cation channel subfamily M member 7
, transient receptor potential melastatin 7
, transient receptor potential cation channel, subfamily M, member 7
, LTRPC ion channel family member 7
, channel-kinase 1
, long transient receptor potential channel 7
, transient receptor potential-phospholipase C-interacting kinase
, transient receptor potential M7
, transient receptor potential-related protein, ChaK