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Transient Receptor Potential Cation Channel, Subfamily M, Member 8 Proteins (TRPM8)

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Additionally we are shipping TRPM8 Antibodies (145) and TRPM8 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRPM8 79054 Q7Z2W7
TRPM8 171382 Q8R4D5
TRPM8 171384 Q8R455
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Top TRPM8 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

TRPM8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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Rat (Rattus)

More Proteins for Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) Interaction Partners

Guinea Pig Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. The data of this study provided evidence for decreased activity and expression level of TRPM8 in the presence of methylglyoxal.

  2. Study used a combination of molecular modeling and experimental techniques to examine the structure of the TRPM8 transmembrane and pore helix region including the conducting conformation of the selectivity filter

  3. Translational and clinical investigation to exploit TRPM8 as a molecular biomarker and therapeutic target is expected to make a positive impact on precision medicine in pancreatic cancer and other malignant diseases.

  4. Several TRPM8 variants appeared to be poorly expressed in transfected HEK293 cells compared with non-mutated TRPM8.

  5. The GC variant of the TRPM8: c.750G > C (rs11562975) polymorphism is associated with cold-induced airway hyperresponsiveness in patients with bronchial asthma.

  6. we found that the androgen-mediated TRPM8 channel activity is negatively regulated by the androgen receptor (show AR Proteins) protein

  7. TRPM8 underlines the important physiologic role of the nose in temperature regulation, both in patients with allergy and those without allergy. Isometric contraction studies demonstrate the role of TRPM8 in regulating nasal patency and airway resistance.

  8. These results are the first to show that menthol directly binds to the TRPM8 sensing domain.

  9. Genetic polymorphisms in TRPM8 genes modify individual susceptibility to metabolic syndrome in a Turkish population.

  10. developed a new functional knockout mouse strain by deleting the pore domain of TRPM8 and demonstrated that eTRPM8 knockout impairs adaptation of the epidermis to low temperatures

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) interaction partners

  1. Reduced functional expression of TRPM8 in sensory neurons (due to VAMP7 (show VAMP7 Proteins) knockout) is associated with deficits in cold avoidance and icilin-induced cold hypersensitivity.

  2. Report essential role of skin TRPM8 in a model of acute cold-induced urinary urgency.

  3. This study findings suggest the existence of VGLUT2 (but not VGLUT1)-mediated glutamate (show GRIN1 Proteins) signaling in TRPM8+ neurons possibly underlying the cold-induced acute pain and hypersensitivity to cold following pulpal inflammation.

  4. Data suggest that blockage of transient receptor potential (TRP) channels TRPA1 (show TRPA1 Proteins), TRPV4 (show TRPV4 Proteins) and possibly TRPM8 may represent a therapeutic option for patients with colonic discomfort and pain.

  5. TRPM8 signaling in mucosal sensory neurons is indispensable for the regulation of innate inflammatory responses via the neuropeptide CGRP (show CALCA Proteins).

  6. TRPM8-expressing dural afferent fibers undergo cell- and target tissue-specific axonal pruning during postnatal development.

  7. our findings suggest that temperature response thresholds in mice are dynamic. PLC (show HSPG2 Proteins)-mediated hydrolysis of phosphoinositol 4,5-bisphosphate modulates TRPM8 activity and thereby regulates the response thresholds to cold stimuli.

  8. ZBTB20 (show ZBTB20 Proteins) regulates nociception and pain sensation by modulating TRPV1 (show TRPV1 Proteins), TRPA1 (show TRPA1 Proteins) and TRPM8 expression in nociceptive sensory neurons.

  9. Increased expression of TRPM8 may contribute to the visceral hyperalgesia of experimental colitis.

  10. Study shows that oxidative stress affects urothelial function involving a TRPM8-mediated mechanism and these effects may have important implications for aging.

TRPM8 Protein Profile

Protein Summary

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Gene names and symbols associated with TRPM8

  • transient receptor potential cation channel, subfamily M, member 8 (TRPM8)
  • transient receptor potential cation channel, subfamily M, member 8 (trpm8-b)
  • transient receptor potential cation channel, subfamily M, member 8 (Trpm8)
  • CMR1 protein
  • LTrpC-6 protein
  • LTRPC6 protein
  • Trp-p8 protein
  • TRPM8 protein
  • trpm8b protein
  • TRPP8 protein

Protein level used designations for TRPM8

transient receptor potential cation channel, subfamily M, member 8 , transient receptor potential cation channel subfamily M member 8b , transient receptor potential cation channel subfamily M member 8 , transient potential cation channel subfamily M member 8 , LTrpC-6 , long transient receptor potential channel 6 , short form of the TRPM8 cationic channel , transient receptor potential p8 , transient receptor potential subfamily M member 8 , trp-p8 , TRP ion channel TRPM8 , transient receptor potential-p8 , cold menthol receptor 1 , cold/menthol receptor 1 , menthol receptor , transient receptor potential M8 protein , transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime , transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime

GENE ID SPECIES
100137386 Papio anubis
100302012 Xenopus laevis
100337634 Cavia porcellus
79054 Homo sapiens
171382 Mus musculus
171384 Rattus norvegicus
424025 Gallus gallus
486170 Canis lupus familiaris
541151 Bos taurus
100328692 Oryctolagus cuniculus
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