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Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008].. Additionally we are shipping TNP1 Kits (11) and TNP1 Proteins (9) and many more products for this protein.
Showing 10 out of 28 products:
Cow (Bovine) Polyclonal TNP1 Primary Antibody for WB - ABIN2785473
Jedrzejczak, Kempisty, Bryja, Mostowska, Depa-Martynow, Pawelczyk, Jagodzinski: Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. in Archives of andrology 2007
Human Polyclonal TNP1 Primary Antibody for IHC, IHC (p) - ABIN4361286
Djureinovic, Fagerberg, Hallström, Danielsson, Lindskog, Uhlén, Pontén: The human testis-specific proteome defined by transcriptomics and antibody-based profiling. in Molecular human reproduction 2014
The elevated levels of the remaining TP in Tnp-mutant mice appeared to be a consequence of the prolonged nucleus retention, rather than increased synthesis.
Epididymal sperm from the Tnp1 null genotypes demonstrated a general decrease in normal morphology, motility, chromatin condensation, and degree of protamine 2 (show PRM2 Antibodies) processing with decreasing levels of transition proteins in mutant sperm.
JHDM2A (show KDM3A Antibodies) directly binds to and controls the expression of transition nuclear protein 1 (show NUPR1 Antibodies) (Tnp1) and protamine 1 (Prm1 (show PRM1 Antibodies)) genes, the products of which are required for packaging and condensation of sperm chromatin
Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 (show RRP8 Antibodies) and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.
frequency of the haplotype GCG (show GCG Antibodies) (H3) was increased in azoospermic men compared with fertile men. expression analysis of the TNP1 gene in obstructive azoospermic men showed that haplotypes of the TNP1 gene do not affect its expression level.
a deletion of 15 nucleotides encompassing the recognition site for the cAMP response element transcription factor was found in the 5'-promoter region of the TNP1 gene in infertile men; this deletion reduces TNP1 expression and may cause infertility
We found significantly lower levels of HILS1, TNP1, and TNP2 (show TNP2 Antibodies) transcripts in spermatozoa from asthenozoospermic men compared to normozoospermic men.
The TNP1 contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos.
The presence of transition proteins (TP1 (show RPLP2 Antibodies) and/or TP2 (show TERT Antibodies)) in spermatids in semen indicates inhibition in the differentiation pathway from round spermatids to spermatozoa in infertile men.
We propose that SNPs on the TNP1 3'-UTR (show UTS2R Antibodies) may help select semen quality trait in Chinese Holstein bulls in the dairy industry.
Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880\; PRM2, MIM 182890) (Luerssen et al., 1990
transition protein 1 (during histone to protamine replacement)
, Spermatid nuclear transition protein 1
, spermatid nuclear transition protein 1
, testis-specific basic protein