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Transportin 3 Proteins (TNPO3)

The protein encoded by TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. Additionally we are shipping Transportin 3 Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TNPO3 23534 Q9Y5L0
TNPO3 320938 Q6P2B1
Rat TNPO3 TNPO3 296954  
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Top Transportin 3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

TNPO3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Transportin 3 (TNPO3) Interaction Partners

Human Transportin 3 (TNPO3) interaction partners

  1. IRF5 (show IRF5 Proteins)-TNPO3 genetic variation is associated systemic lupus erythematosus.

  2. Data suggest that the HIV-1 integrase (IN)/transportin-SR2 (TRN-SR2) interaction interface is a potential target for antiviral therapy.

  3. Tnpo3 mutants that are not able to interact with cleavage and polyadenylation specificity factor 6 (show CPSF6 Proteins) do not facilitate HIV-1 infectivity, suggesting a potential route of pharmacological intervention in the treatment of AIDS.

  4. In skeletal muscle of limb-girdle muscular dystrophy 1F individuals, expression of transportin 3 indicates altered transportin 3 function.

  5. The TNPO3 gene is mapped within the Limb-girdle muscular dystrophy 1F critical interval and its 923-amino acid human gene product is also expressed in skeletal muscle.

  6. a model wherein one monomer of TRN-SR2 is bound to one monomer of RanGTP.

  7. These results suggested that inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6 (show CPSF6 Proteins).

  8. TNPO3 promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 (show CPSF6 Proteins) to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6 (show CPSF6 Proteins).

  9. These results suggest that TNPO3 and cyclophilin A (show PPIA Proteins) facilitate HIV-1 infection by coordinating proper uncoating of the core in target cells.

  10. Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.

Transportin 3 (TNPO3) Protein Profile

Protein Summary

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.

Gene names and symbols associated with Transportin 3 Proteins (TNPO3)

  • transportin 3 (tnpo3)
  • transportin 3 (TNPO3)
  • transportin-SR (Bm1_43850)
  • transportin-SR (LOAG_04608)
  • transportin 3 (Tnpo3)
  • 5730544L10Rik protein
  • C81142 protein
  • C430013M08Rik protein
  • D6Ertd313e protein
  • DKFZp459J2330 protein
  • IPO12 protein
  • MGC82948 protein
  • mKIAA4133 protein
  • MTR10A protein
  • TNPO3 protein
  • Trn-SR protein
  • TRN-SR2 protein
  • TRNSR protein
  • zgc:55409 protein

Protein level used designations for Transportin 3 Proteins (TNPO3)

transportin-3 , transportin 3 , transportin-SR , imp12 , importin 12

GENE ID SPECIES
394062 Danio rerio
426277 Gallus gallus
447036 Xenopus laevis
463715 Pan troglodytes
482263 Canis lupus familiaris
537183 Bos taurus
700852 Macaca mulatta
6103654 Brugia malayi
9942010 Loa loa
100015111 Monodelphis domestica
100174329 Pongo abelii
100395851 Callithrix jacchus
100477279 Ailuropoda melanoleuca
100490799 Xenopus (Silurana) tropicalis
100515455 Sus scrofa
100543440 Meleagris gallopavo
23534 Homo sapiens
320938 Mus musculus
296954 Rattus norvegicus
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