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anti-Treacher Collins-Franceschetti Syndrome 1 (TCOF1) Antibodies

TCOF1 encodes a nucleolar protein with a LIS1 homology domain. Additionally we are shipping TCOF1 Proteins (4) and TCOF1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat TCOF1 TCOF1 291571  
TCOF1 21453 O08784
TCOF1 6949 Q13428
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Top anti-TCOF1 Antibodies at antibodies-online.com

Showing 10 out of 36 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TCOF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of TCOF1 expression in transfected 293T cell line by TCOF1 monoclonal antibody (M02), clone 8H3. Lane 1: TCOF1 transfected lysate(152.104 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ChIP, IC, IF, IHC, WB Immunofluorescent analysis of TCOF1 staining in HEK293T cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of TCOF1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) Western blot analysis of extracts from Jurkat/293/HeLa cells, using TCOF1 Antibody . The lane on the right is treated with the synthesized peptide. 50 μg Log in to see 6 to 8 Days
$500.50
Details
Xenopus laevis Mouse Un-conjugated IHC (fro), IF, WB   5 mL Log in to see 6 to 8 Days
$286.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB   100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated IP Immunoprecipitation of TCOF1 transfected lysate using anti-TCOF1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with TCOF1 MaxPab mouse polyclonal antibody (B01) . 100 μL Log in to see 9 Days
$418.57
Details

TCOF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Human , , , ,
, ,
,

Top referenced anti-TCOF1 Antibodies

  1. Xenopus laevis Monoclonal TCOF1 Primary Antibody for IHC (fro), IF - ABIN126712 : Derenzini, Romagnoli, Mingazzini, Marinozzi: Interphasic nucleolar organizer region distribution as a diagnostic parameter to differentiate benign from malignant epithelial tumors of human intestine. in Virchows Archiv. B, Cell pathology including molecular pathology 1988 (PubMed)
    Show all 3 references for ABIN126712

  2. Human Polyclonal TCOF1 Primary Antibody for IHC, ELISA - ABIN1533867 : So, Gonzales, Henning, Dixon, Dixon, Valdez: Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons. in Gene 2004 (PubMed)

More Antibodies against TCOF1 Interaction Partners

Mouse (Murine) Treacher Collins-Franceschetti Syndrome 1 (TCOF1) interaction partners

  1. Tcof1 acts as a modifier of Pax3 (show PAX3 Antibodies) during enteric nervous system development.

  2. identified Tcof1 as an important regulator of vagal neural crest cells (NCC (show SLC12A3 Antibodies)) development and enteric nervous system formation; Tcof1 loss-of-function results in a deficiency of vagal NCC (show SLC12A3 Antibodies) and their delayed colonization of the gut (show GUSB Antibodies) during early embryogenesis, which mimics the early stages of Hirschsprung's disease

  3. our research has therefore identified Treacle and as novel in vivo regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells.

  4. Loss-of-function mutation in Tcof1 results in defects in middle ear postnatal development and conductive hearing loss.

  5. Results show that treacle is involved in ribosomal DNA gene transcription by interacting with upstream binding factor (UBF (show UBTF Antibodies)).

  6. Data show that Tcof1 and treacle synthesis play an important role in the proliferation of neuroblastoma (show ARHGEF16 Antibodies) cells.

  7. Analysis of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a lethal phenotype showed significant reduction in 2'-O-methylation at nucleotide C463 of 18S rRNA

  8. A minimal promoter fragment from -253 to +43 bp (show EIF4EBP1 Antibodies) directs constitutive expression in both cell types, and dual regulation of Tcof1 appears to be through differential repression of this minimal promoter.

  9. It has been hypothesized that mutations in Tcof1 disrupt ribosome biogenesis to a degree that is insufficient to meet the proliferative needs of the neuroepithelium and neural crest cells.

Human Treacher Collins-Franceschetti Syndrome 1 (TCOF1) interaction partners

  1. Autosomal recessive POLR1D (show POLR1D Antibodies) mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome.

  2. findings identify TCOF1 as a DDR (show DDR1 Antibodies) factor that could cooperate with ATM (show ATM Antibodies) and NBS1 (show NBN Antibodies) to suppress inappropriate rDNA transcription and maintain genomic integrity after DNA damage.

  3. we describe for the first time, two patients with MFD (show SCYL1 Antibodies) and ID and for whom a deletion encompassing TCOF1 and CAMK2A (show CAMK2A Antibodies) has been identified

  4. Mutations in TCOF1, POLR1C (show POLR1C Antibodies) and POLR1D (show POLR1D Antibodies) have all been implicated in causing TCS

  5. Treacle-mediated NBS1 (show NBN Antibodies) recruitment into the nucleoli regulates rRNA silencing in trans in the presence of distant chromosome breaks.

  6. TCOF1 genetic mutation can be a cause of Treacher Collins syndrome in Chinese patients.

  7. Presents the case of a male with Treacher Collins syndrome with a heterozygous de novo frameshift mutation within the TCOF1 gene (c.790_791delAG,p.Ser264GlnfsX7), as well as findings from three other individuals from two families with the same mutation.

  8. 6 of 12 patients diagnosed with hemifacial microsomia exhibited a novel frameshift mutation c. 4127 ins (show INS Antibodies) G in exon 24 in the TCOF1 gene.

  9. Gene rearrangements in TCOF1 are responsible for Treacher-Collins-Franceschetti syndrome.

  10. We demonstrated that adult leucocytes and mesenchymal cells from TCS patients present significantly reduced levels of TCOF1

TCOF1 Antigen Profile

Protein Summary

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TCOF1

  • Treacher Collins-Franceschetti syndrome 1 (Tcof1) antibody
  • Treacher Collins-Franceschetti syndrome 1 (TCOF1) antibody
  • Treacher Collins-Franceschetti syndrome 1 (LOC100226238) antibody
  • Treacher Collins-Franceschetti syndrome 1 (LOC100341764) antibody
  • Treacher Collins Franceschetti syndrome 1, homolog (Tcof1) antibody
  • AA408847 antibody
  • AW209012 antibody
  • MFD1 antibody
  • TCOF1 antibody
  • TCS1 antibody
  • treacle antibody

Protein level used designations for TCOF1

Treacher Collins Franceschetti syndrome 1, homolog , Treacher Collins-Franceschetti syndrome 1 homolog , treacle protein , tcof1 gene exons 14-15-16a-16b , tcof1 gene exons 7-13 , treacle , Treacher Collins-Franceschetti syndrome 1 , treacle protein-like , treacher Collins syndrome protein homolog , Treacher Collins syndrome protein , nucleolar trafficking phosphoprotein

GENE ID SPECIES
291571 Rattus norvegicus
403592 Canis lupus familiaris
416276 Gallus gallus
471696 Pan troglodytes
513591 Bos taurus
664735 Macaca mulatta
100060348 Equus caballus
100226238 Taeniopygia guttata
100341764 Oryctolagus cuniculus
100435631 Pongo abelii
100471510 Ailuropoda melanoleuca
100591432 Nomascus leucogenys
21453 Mus musculus
6949 Homo sapiens
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