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Tribbles Homolog 2 (Drosophila) Proteins (TRIB2)

TRIB2 encodes one of three members of the Tribbles family. Additionally we are shipping Tribbles Homolog 2 (Drosophila) Antibodies (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIB2 28951 Q92519
TRIB2 217410 Q8K4K3
Rat TRIB2 TRIB2 313974  
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Top Tribbles Homolog 2 (Drosophila) Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,929.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,929.67
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,929.67
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

TRIB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced Tribbles Homolog 2 (Drosophila) Proteins

  1. Human TRIB2 Protein expressed in Baculovirus infected Insect Cells - ABIN2003302 : Seher, Leptin: Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation. in Current biology : CB 2000 (PubMed)
    Show all 3 references for ABIN2003302

  2. Human TRIB2 Protein expressed in Wheat germ - ABIN1323589 : Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ... in The Journal of biological chemistry 2013 (PubMed)

More Proteins for Tribbles Homolog 2 (Drosophila) (TRIB2) Interaction Partners

Xenopus laevis Tribbles Homolog 2 (Drosophila) (TRIB2) interaction partners

  1. tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development

Human Tribbles Homolog 2 (Drosophila) (TRIB2) interaction partners

  1. High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 (show TAL1 Proteins) complex in T-cell acute lymphoblastic leukemia.

  2. Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 and TRIB3 (show TRIB3 Proteins) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.

  3. Studies suggest that pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 and TRIB3 (show TRIB3 Proteins) were involved in the pathogenesis of inflammation.

  4. Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.

  5. Studies indicate that the molecular interactions that take place between tribbles homolog 2 (Drosophila) protein (TRIB2) and factors involved in the ubiquitin proteasome system (UPS) are varied and have differential downstream effects.

  6. Studies indicate that small molecules can reveal rate-limiting signalling outputs and functions of pseudo-kinase family of tribbles (show TRIB1 Proteins) (TRIB) proteins TRIB1 (show TRIB1 Proteins), TRIB2 and TRIB3 (show TRIB3 Proteins) in cells and intact organisms, serving as guides for the development of new drugs.

  7. Studies show that TRIB1 (show TRIB1 Proteins) and TRIB2 are highly expressed in molecularly-defined sub-types of acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).

  8. Studies show a remarkable reduction in tribbles (show TRIB1 Proteins) 2 protein (Trib2) expression during oocyte maturation whereas tribbles (show TRIB1 Proteins) 1 protein (Trib1 (show TRIB1 Proteins)) and tribbles 3 (show TRIB3 Proteins) protein (Trib3 (show TRIB3 Proteins)) expression was significantly increased during this process.

  9. The results suggest that TRIB2 is a meaningful biomarker reflecting diagnosis and progression of melanoma, as well as predicting clinical response to chemotherapy.

  10. Data suggest that TRB2 exhibits metal-independent autophosphorylation activity, low affinity ATP binding/hydrolysis, and a conserved catalytic lysine residue in the active site (rather than the asparagine in many metal-dependent kinases).

Mouse (Murine) Tribbles Homolog 2 (Drosophila) (TRIB2) interaction partners

  1. TRIB1 (show TRIB1 Proteins) and TRIB3 (show TRIB3 Proteins) are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.

  2. we identify the contribution of dysregulated C/EBPalpha (show CEBPA Proteins) and E2F1 (show E2F1 Proteins) to elevated Trib2 expression and leukemic cell survival

  3. Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia (show BCL11A Proteins).

  4. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.

  5. Data identify Tribbles homolog 2 as an oncogene (show RAB1A Proteins) that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha (show CEBPA Proteins).

  6. describe suppression of adipocyte differentiation by TRBs Trib1 (show TRIB1 Proteins), Trib2, Trib3 (show TRIB3 Proteins)

  7. Mice reconstituted with HSC (show FUT1 Proteins) cotransduced with HoxA9 (show HOXA9 Proteins) and Trib2 had accelerated onset of AML (show RUNX1 Proteins) compared to either gene alone

  8. Linkage of Meis1 (show MEIS1 Proteins) leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3 (show CCL3 Proteins).

  9. These results suggest that Trb2 plays minimal roles during kidney and mouse development.

Tribbles Homolog 2 (Drosophila) (TRIB2) Protein Profile

Protein Summary

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with TRIB2

  • tribbles homolog 2 (Drosophila) (TRIB2)
  • tribbles homolog 2 (Drosophila) (trib2)
  • tribbles homolog 2 (trib2)
  • tribbles homolog 2 (LOC100357208)
  • tribbles homolog 2 (Drosophila) (Trib2)
  • AW319517 protein
  • C5FW protein
  • GS3955 protein
  • RGD1564451 protein
  • TRB-2 protein
  • TRB2 protein
  • TRIB2 protein
  • xtrb2 protein
  • Xtrbl protein

Protein level used designations for TRIB2

tribbles homolog 2 (Drosophila) , tribbles homolog 2-like , tribbles homolog 2 , serine/threonine protein kinase , tribbles-like protein 2 , TRB-2

GENE ID SPECIES
459038 Pan troglodytes
100331041 Danio rerio
394677 Xenopus (Silurana) tropicalis
100357208 Oryctolagus cuniculus
100528799 Ictalurus punctatus
378920 Xenopus laevis
378919 Gallus gallus
28951 Homo sapiens
403884 Canis lupus familiaris
352960 Bos taurus
217410 Mus musculus
313974 Rattus norvegicus
100173599 Pongo abelii
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