Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The protein encoded by TRIM25 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM25 Proteins (5) and TRIM25 Kits (1) and many more products for this protein.
Showing 10 out of 133 products:
Human Polyclonal TRIM25 Primary Antibody for BCA - ABIN2666116
Gack, Kirchhofer, Shin, Inn, Liang, Cui, Myong, Ha, Hopfner, Jung: Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 4 references for 2666116
Human Monoclonal TRIM25 Primary Antibody for IF, IP - ABIN968044
Inoue, Orimo, Hosoi, Kondo, Toyoshima, Kondo, Ikegami, Ouchi, Orimo, Muramatsu: Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. in Proceedings of the National Academy of Sciences of the United States of America 1994
the data uncover TRIM25 as a bona fide zinc-finger antiviral protein (show ZC3HAV1 Antibodies) cofactor that leads to increased zinc-finger antiviral protein (show ZC3HAV1 Antibodies) modification enhancing its translational inhibition activity.
Studies showed that 70% of breast cancer patients were positive for Trim25 expression.
we provide a detailed characterization of the TRIM (show TRAT1 Antibodies) ligases TRIM25 and TRIM32 (show TRIM32 Antibodies) and show how their oligomeric state is linked to catalytic activity
The severe acute respiratory syndrome coronavirus N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase (show MUL1 Antibodies), thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I (show DDX58 Antibodies)) and inhibiting TRIM25-mediated RIG-I (show DDX58 Antibodies) ubiquitination and activation.
TRIM25 is required for Zinc finger antiviral protein (show ZC3HAV1 Antibodies) optimal binding to target mRNA.
TRIM25 may exert its function through TGF-beta (show TGFB1 Antibodies) pathway.
TRIM25 plays an additional role in RIG-I (show DDX58 Antibodies)/MDA5 (show IFIH1 Antibodies) signaling other than RIG-I (show DDX58 Antibodies) ubiquitination via activation of NF-kappaB (show NFKB1 Antibodies).
Data show that TRIM25 enhances p53 (show TP53 Antibodies) and Mdm2 (show MDM2 Antibodies) abundance by preventing their proteasomal degradation. At the same time, TRIM25 inhibits p53 (show TP53 Antibodies)'s transcriptional activity and dampens the response to DNA damage.
The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (show RARRES3 Antibodies) (RIG-I (show DDX58 Antibodies))-induced type I interferon (show IFNA Antibodies) expression.
Trim25 binds to the conserved terminal loop (CTL) of pre-let-7 and activates TuT4 (show ZCCHC11 Antibodies), allowing for more efficient Lin28a (show LIN28A Antibodies)-mediated uridylation.
Studies indicated that mice with disrupted Trim25 were viable and fertile, uterine response to oestrogen was greatly attenuated and the uteri were underdeveloped.
Two key residues (Asp (show C3 Antibodies)(488) and Trp (show TYRP1 Antibodies)(621)) in the TRIM25 B30.2 domain are critical for binding to the RIG-I (show DDX58 Antibodies) CARDs.
Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (show TRIM71 Antibodies) (also called Lin41 (show TRIM71 Antibodies)), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
tripartite motif-containing 25
, E3 ubiquitin/ISG15 ligase TRIM25
, tripartite motif containing 25
, RING finger protein 147
, estrogen-responsive finger protein
, tripartite motif protein TRIM25
, tripartite motif-containing protein 25
, ubiquitin/ISG15-conjugating enzyme TRIM25
, zinc finger protein 147 (estrogen-responsive finger protein)
, zinc finger protein-147
, tripartite motif protein 25
, zinc finger protein 147